Publications by authors named "Minggen Jin"
Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study.
Ann Intensive Care
January 2025
Background: Invasive procedures and environmental factors in the intensive care unit (ICU) may cause anxiety and discomfort in patients, who often require sedation therapy. The aim of this study was to assess the safety of remimazolam tosilate for procedural sedation in ICU patients receiving mechanical ventilation following endotracheal intubation. Eighty patients from a single centre were randomly assigned to either the propofol group or the remimazolam group.
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- Recent research has indicated that Xuebijing injection (XBJ), an herbal intravenous treatment, may lower death rates in sepsis patients.
- The EXIT-SEP trial, involving 1817 patients in 45 intensive care units, aimed to assess the effect of XBJ versus a placebo on 28-day mortality in sepsis patients.
- Results showed a significant reduction in mortality for those receiving XBJ compared to placebo, meaning XBJ could be a promising treatment option for sepsis.
BACKGROUND This study investigated the role and mechanism of alprostadil in acute respiratory distress syndrome (ARDS) induced by oleic acid (OA) in rats. MATERIAL AND METHODS Sprague-Dawley rats were randomly divided into control, OA model, and OA + Alprostadil (2.5, 5, and 10 μg/kg, respectively) groups.
View Article and Find Full Text PDF[Anti-inflammatory effects of penehyclidine hydrochloride on acute respiratory distress syndrome in rats].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
August 2018
Objective: To investigate the anti-inflammatory effect of penehyclidine hydrochloride on oleic acid-induced acute respiratory distress syndrome (ARDS) in rats.
Methods: According to randomize number table method, 30 adult male Sprague-Dawley (SD) rats were divided into control group, model group and treatment group. Catheters were placed in femoral vein in each group.
Dipeptidyl peptidase IV (DPP-IV) is a complex enzyme that acts as a membrane-anchored cell surface exopeptidase and transmits intracellular signals through a small intracellular tail. DPP-IV exists in human blood in a soluble form, and truncates a large number of peptide hormones, chemokines, cytokines, and growth factors in vitro and in vivo. DPP-IV has gained considerable interest as a therapeutic target, and a variety of DPP-IV inhibitors that prolong the insulinotropic effects of glucagon-like peptide-1 (GLP-1) are widely used in clinical settings as antidiabetic drugs.
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