Fine-tuning protocols for accurate study of nanoparticle adhesion and uptake after foliar deposition.

Understanding the interactions between plant leaves and nanoparticles (NPs) is crucial for advancing both environmental and the safety of plant protection products. Recent studies showed how the fate of NPs on leaf surfaces is influenced by NP properties, plant surface, and environmental factors. Yet, inconsistent methods for exposing leaves and measuring NPs uptake hinder reproducibility and comparability across studies.

Effect of a Zinc Phosphate Shell on the Uptake and Translocation of Foliarly Applied ZnO Nanoparticles in Pepper Plants ().

Here, isotopically labeled ZnO NPs (ZnO NPs) and ZnO NPs with a thin Zn(PO) shell (ZnO_Ph NPs) were foliarly applied (40 μg Zn) to pepper plants () to determine the effect of surface chemistry of ZnO NPs on the Zn uptake and systemic translocation to plant organs over 6 weeks. Despite similar dissolution of both Zn-based NPs after 3 weeks, the Zn(PO) shell on ZnO_Ph NPs (48 ± 12 nm; -18.1 ± 0.

Effects of a TAFI-inhibitor combined with a suboptimal dose of rtPA in a murine thromboembolic model of stroke.

Background: Since thrombolysis is the only approved intervention for ischemic stroke, improving its efficacy and safety is a therapeutic aim of considerable interest. The activated form of thrombin activatable fibrinolysis inhibitor (TAFI) has antifibrinolytic effects, and inhibition of TAFI might thus favor recanalization. The present study compared efficacy between TAFI inhibition alone and TAFI inhibition in combination with rtPA at a suboptimal dose, in a murine model of thromboembolic stroke.