Publications by authors named "Michiel D Vriesendorp"
Article Synopsis
- The study examined differences in echocardiographic assessments of native and bioprosthetic aortic valves between core laboratories and clinical centers, finding clinically relevant discrepancies.
- Data was collected from the PERIGON trial, which involved patients undergoing surgical aortic valve replacement, and involved comparing echocardiographic results from centers to independent analysis by a core lab.
- Results showed that while some continuous measurements had high agreement (around 0.90), there were notable variances, particularly in left ventricular outflow tract area and stroke volume, indicating the need for standardized evaluation practices.
Objective: Literature presents conflicting results on the pros and cons of pledget-reinforced sutures during surgical aortic valve replacement (SAVR). We aimed to investigate the effect of pledget-reinforced sutures versus sutures without pledgets during SAVR on different outcomes in a systematic review and -analysis.
Methods: A literature search was performed in five different medical literature databases.
Objective: New echocardiographic definitions have been proposed for hemodynamic structural valve deterioration. We aimed to study their consistency in classifying structural valve deterioration after surgical aortic valve replacement.
Methods: Data were used of patients undergoing surgical aortic valve replacement in a multicenter, prospective cohort study with a 5-year follow-up.
Background: Although various hemodynamic parameters to assess prosthetic performance are available, prosthesis-patient mismatch (PPM) is defined exclusively by effective orifice area (EOA) index thresholds. Adjusting for the Society of Thoracic Surgeons predicted risk of mortality (STS PROM), we aimed to explore the added value of postoperative hemodynamic parameters for the prediction of all-cause mortality at 5 years after aortic valve replacement.
Methods: Data were obtained from the Pericardial Surgical Aortic Valve Replacement (PERIGON) Pivotal Trial, a multicenter prospective cohort study examining the performance of the Avalus bioprosthesis.
Objectives: A flow-gradient classification is used to determine the indication for intervention for patients with severe aortic stenosis (AS) with discordant echocardiographic parameters. We investigated the agreement in flow-gradient classification by stroke volume (SV) measurement at the left ventricular outflow tract (LVOT) and at the left ventricle.
Methods: Data were used from a prospective cohort study and patients with severe AS (aortic valve area index ≤0.
Improving accuracy in diagnosing aortic stenosis severity: An in-depth analysis of echocardiographic measurement error through literature review and simulation study.
Echocardiography
September 2023
Article Synopsis
- - The study focuses on how measurement errors in echocardiograms can affect the diagnosis of severe aortic stenosis (AS), a condition where the aortic valve narrows, which can lead to unnecessary surgeries.
- - Out of 37 studies evaluated, nearly half acknowledged measurement errors, but none effectively addressed them, highlighting a significant gap in research practice.
- - Clinical simulations showed that these measurement errors could misclassify up to 42% of patients, emphasizing the need for more accurate assessments to guide treatment decisions and research outcomes.
Objectives: It is unknown which confounding adjustment methods are currently used in the field of cardiothoracic surgery and whether these are appropriately applied. The aim of this study was to systematically evaluate the quality of conduct and reporting of confounding adjustment methods in observational studies on cardiothoracic interventions.
Methods: A systematic review was performed, which included all observational studies that compared different interventions and were published between 1 January and 1 July 2022, in 3 European and American cardiothoracic surgery journals.
Article Synopsis
- - The study aimed to assess the impact of annular enlargement (ARE) during surgical aortic valve replacement on mortality and complications over a five-year period, amid ongoing debate about its safety and efficacy.
- - Data from 602 patients in a multinational trial showed that 15% underwent ARE, and both groups had similar rates of mortality and major complications within 30 days post-surgery and at five years.
- - Results indicated that patients who had the ARE procedure had comparable five-year survival rates (91% vs. 89%) and experienced similar outcomes in terms of valve functionality, implying that ARE does not significantly worsen patient outcomes.
Objective: To describe differences between North America and Europe in the perioperative management of patients undergoing surgical aortic valve replacement (SAVR).
Methods: Patients with moderate or greater aortic stenosis or regurgitation requiring SAVR were enrolled in a prospective observational cohort evaluating the safety and efficacy of a new stented bioprosthesis at 25 centres in North America (Canada and the USA) and 13 centres in Europe (Germany, the Netherlands, France, the UK, Switzerland and Italy). While all patients underwent implantation with the same bioprosthetic model, perioperative management was left to the discretion of participating centres.
Objective: The objective of this study was to compare short- and midterm clinical and echocardiographic outcomes according to the use of pledgeted sutures during aortic valve replacement.
Methods: Patients with aortic stenosis or regurgitation requiring aortic valve replacement were enrolled in a prospective cohort study to evaluate the safety of a new stented bioprosthesis. Outcomes were analyzed according to the use of pledgets (pledgeted group) or no pledgets (nonpledgeted group).
Background: The advent of transcatheter aortic valve replacement (AVR) has led to an increased emphasis on reducing the invasiveness of surgical procedures. The aim of this study was to evaluate clinical outcomes and hemodynamic performance achieved with minimally invasive aortic valve replacement (MI-AVR) as compared with conventional AVR.
Methods: Patients who underwent surgical AVR with the Avalus bioprosthesis, as part of a prospective multicenter non-randomized trial, were included in this analysis.
Why the categorization of indexed effective orifice area is not justified for the classification of prosthesis-patient mismatch.
J Thorac Cardiovasc Surg
September 2022
Objectives: Although the impact of prosthesis-patient mismatch (PPM) on survival has been widely studied, there has been little debate about whether the current definition of PPM truly reflects hemodynamic obstruction. This study aimed to validate the categorization of indexed effective orifice area (EOAi) for the classification of PPM.
Methods: In total, 2171 patients who underwent aortic valve replacement with a surgical stented bioprosthesis in 5 trials (CoreValve US High-Risk, SURTAVI [Surgical Replacement and Transcatheter Aortic Valve Implantation Trial], Evolut Low Risk, PERIGON [PERIcardial SurGical AOrtic Valve ReplacemeNt] Pivotal Trial for the Avalus valve, and PERIGON Japan) were used for this analysis.
The fallacy of indexed effective orifice area charts to predict prosthesis-patient mismatch after prosthesis implantation.
Eur Heart J Cardiovasc Imaging
October 2020
Article Synopsis
- The study aimed to validate indexed effective orifice area (EOAi) charts for predicting prosthesis-patient mismatch (PPM) after aortic valve replacement (AVR) using echocardiographic reference values.
- In the PERIGON trial, 986 patients were assessed to create an EOAi chart based on training and test sets, revealing a high incidence of PPM but significant mispredictions in 30% of cases.
- The findings concluded that relying on these reference values for EOAi charts is unreliable for accurately predicting PPM due to a large number of misclassifications.
Antithrombotic therapy and bleeding events after aortic valve replacement with a novel bioprosthesis.
J Thorac Cardiovasc Surg
January 2021
Objective: Several recent-generation surgical tissue valves have been found to have bleeding rates exceeding rates recommended by regulatory bodies. We explored bleeding events using data from the Pericardial Surgical Aortic Valve Replacement (PERIGON) Pivotal Trial for the Avalus valve (Medtronic, Minneapolis, Minn) to examine whether this end point remains relevant for the evaluation of bioprostheses.
Methods: Patients (n = 1115) underwent aortic valve replacement.
An in vitro comparison of internally versus externally mounted leaflets in surgical aortic bioprostheses.
Interact Cardiovasc Thorac Surg
March 2020
Objectives: To improve haemodynamic performance, design modifications of prosthetic valves have been proposed with each new generation of valves. These different designs also impact the amount of mechanical wear, because mechanical stresses are distributed differently. Because long-term evidence for new prosthetic valves is lacking, this in vitro study compared hydrodynamic performance and durability among 3 currently available bioprosthetic valves with internally (IMLV) or externally mounted leaflets (EMLV).
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