Multiparametric Approach to Arrhythmic Mitral Valve Prolapse: Novel and Recognized Markers of Increased Sudden Cardiac Arrest Risk.

Background: Mitral valve prolapse (MVP) in some cases may predispose to life-threatening ventricular arrhythmias. The aims of this study were to evaluate determinants of arrhythmic MVP (AMVP) in a large population and to identify variables associated with sudden cardiac arrest (SCA) or sudden cardiac death.

Methods: This ambispective cohort study included patients 18 to 70 years of age with MVP with preserved ejection fraction and no coronary artery disease, cardiomyopathies, or channelopathies.

The effect of short term amiodarone treatment on the effectiveness of catheter ablation in patients with persistent atrial fibrillation refractory to cardioversion.

Background: Little is known about the effect of amiodarone therapy in patients with persistent atrial fibrillation refractory to electrical cardioversion (AF-REC) scheduled for catheter ablation (CA).

Aims: This study aimed to determine whether postulated atrial reverse remodelling achieved through short-term pre- and post-ablation amiodarone therapy with sinus rhythm restoration prior to CA affects the long-term effectiveness of the rhythm control strategy in AF-REC patients.

Material And Methods: AF-REC patients scheduled for CA were included in this retrospective study.

Mitral valve prolapse in sudden cardiac arrest survivors: Coincidence or causal relationship?

Background: Sudden cardiac arrest (SCA) risk stratification in patients with mitral valve prolapse (MVP) may be complicated by other potential causes of arrhythmia.

Objective: We aimed to characterize SCA survivors with isolated MVP (iMVP) and non-isolated MVP (non-iMVP) and to assess their long-term follow-up.

Methods: This ambispective study included 75 patients with MVP who experienced SCA and were treated in our center between 2009 and 2024.

Patient and Caregiver Perspectives on Gender Disparity in CKD: An Interview Study.

Key Points: Women felt vulnerable and felt that their housework obligations may interfere with CKD treatment, especially dialysis. Women felt they were good at protecting their health, whereas men might expect help from others and live in denial when confronted with advanced CKD.

Background: CKD affects more women than men worldwide; however, men comprise most patients who receive KRT.

Subcutaneous implantable cardioverter-defibrillator therapy in Poland: Results of the Polish S-ICD Registry.

Background: The use of subcutaneous implantable cardioverter-defibrillators (S-ICD) has been growing in Poland since 2014. The Polish Registry of S-ICD Implantations was run by the Heart Rhythm Section of the Polish Cardiac Society between May 2020 and September 2022 to monitor the implementation of that therapy in Poland.

Aims: To investigate and present the state-of-the-art of S-ICD implantation in Poland.

Mexiletine for recurrent ventricular tachycardia in adult patients with structural heart disease and implantable cardioverter defibrillator: an EHRA systematic review.

The aim of the study was to systematically review evidence on the effectiveness and safety of oral mexiletine administered in monotherapy or in combination with other antiarrhythmic drugs for recurrent ventricular arrhythmia (ventricular tachycardia/ventricular fibrillation, VT/VF) in adult patients with structural heart disease (SHD) and implantable cardioverter defibrillators (ICDs). We systematically searched MEDLINE, Embase, and CENTRAL databases from inception to 27 August 2021 for prospective and retrospective studies investigating mexiletine in the target population. The main outcome was the reduction of ICD therapy.

Nephrologists' Perspectives on Gender Disparities in CKD and Dialysis.

Introduction: Globally, there are more women with chronic kidney disease (CKD), yet they comprise only 40% of patients receiving kidney replacement therapy by dialysis. We aimed to describe the perspectives of nephrologists on gender disparities in access to care and outcomes in CKD and dialysis.

Methods: We conducted semistructured interviews with 51 nephrologists (28, 55% women) from 22 countries from October 2019 to April 2020.

Titin-Related Dilated Cardiomyopathy: The Clinical Trajectory and the Role of Circulating Biomarkers in the Clinical Assessment.

Titin truncating variants (tv) are known as the leading cause of inherited dilated cardiomyopathy (DCM). Nevertheless, it is unclear whether circulating cardiac biomarkers are helpful in detection and risk assessment. We sought to assess 1) early indicators of cardiotitinopathy including the serum biomarkers high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in clinically stable patients, and 2) predictors of outcome among tv carriers.

A Review of the Commercially Available ECG Detection and Transmission Systems-The Fuzzy Logic Approach in the Prevention of Sudden Cardiac Arrest.

Sudden cardiac death (SCD) constitutes a major clinical and public health problem, whose death burden is comparable to the current worldwide pandemic. This comprehensive review encompasses the following topics: available rescue systems, wearable electrocardiograms (ECG), detection and transmission technology, and a newly developed fuzzy logic algorithm (FA) for heart rhythm classification which is state-of-the art in the field of SCD prevention. Project "PROTECTOR", the Polish Rapid Transtelephonic ECG to Obtain Resuscitation for development of a rapid rescue system for patients at risk of sudden cardiac arrest (SCA), is presented.

Utilization of Subcutaneous Cardioverter-Defibrillator in Poland and Europe-Comparison of the Results of Multi-Center Registries.

The implantation of a subcutaneous cardioverter-defibrillator (S-ICD) may be used instead of a traditional transvenous system to prevent sudden cardiac death. Our aim was to compare the characteristics of S-ICD patients from the multi-center registry of S-ICD implantations in Poland with the published results of the European Snapshot Survey on S-ICD Implantation (ESSS-SICDI). We compared data of 137 Polish S-ICD patients with 68 patients from the ESSS-SICDI registry.

RR interval analysis based on a newly developed PC program as a predictor of interventions in implantable cardioverter-defibrillator patients.

Background: Prediction of sudden cardiac death remains a significant challenge. There is some evidence that ventricular ectopic activity could be regarded as a predictive marker.

Objectives: We carried out an analysis to explore whether premature ventricular complexes (PVCs) are a risk factor in implantable cardioverter-defibrillator (ICD) interventions.

Sex differences in chronic kidney disease awareness among US adults, 1999 to 2018.

Background: Chronic kidney disease (CKD) is less prevalent among men than women, but more men than women initiate kidney replacement therapy. Differences in CKD awareness may contribute to this gender gap, which may further vary by race/ethnicity. We aimed to investigate trends in CKD awareness and the association between individual characteristics and CKD awareness among US men versus women.

Children and young adults treated with transvenous and subcutaneous implantable cardioverter-defibrillators: a 22-year single-center experience and new perspectives.

Background: Over the last several years the evolution of transvenous implantable cardioverter‑defibrillator (T‑ICD) system and the introduction of subcutaneous ICD (S‑ICD) have contributed to the development of the sudden cardiac death (SCD) prevention in clinical practice.

Aims: To report our clinical experience with ICD therapy in children and young adults during the twenty‑ ‑two years of the follow‑up.

Methods: We reviewed the database of ICD recipients choosing 80 consecutive patients (pts) implanted at the age of 6-21 in 1996-2018.

Can Circulating Cardiac Biomarkers Be Helpful in the Assessment of Mutation Carriers?

Mutations in the lamin A/C gene are variably phenotypically expressed; however, it is unclear whether circulating cardiac biomarkers are helpful in the detection and risk assessment of cardiolaminopathies. We sought to assess (1) clinical characteristics including serum biomarkers: high sensitivity troponin T (hsTnT) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) in clinically stable cardiolaminopathy patients, and (2) outcome among pathogenic/likely pathogenic lamin A/C gene ( mutation carriers. Our single-centre cohort included 53 patients from 21 families.