Treatment variations in localised prostate cancer in Australia and New Zealand: a registry study.

Objective: To describe the patterns of care and factors associated with treatment uptake of localised prostate cancer, using the bi-national Prostate Cancer Outcomes Registry-Australia and New Zealand (PCOR-ANZ) database.

Methods: Data for 36 504 patients, diagnosed between 2015 and 2018, from New Zealand and seven Australian jurisdictions were evaluated. Multinomial logistic regression was performed to identify factors associated with the likelihood of receiving no active treatment, radiotherapy (RT), androgen deprivation therapy (ADT) and combined ADT + RT, compared to radical prostatectomy (RP).

BCG Intolerance in Nonmuscle Invasive Bladder Cancer-A Systematic Review.

Background: Most patients with localized bladder cancer are initially managed with endoscopic resection. For high-grade nonmuscle invasive bladder cancer (NMIBC), intravesical Bacillus Calmette-Guerin (BCG) therapy is the gold standard adjuvant treatment. However, 30%-40% of patients fail BCG treatment with lack of response or disease relapse.

Socioeconomic and Geographic Disparities in Anorectal and Urinary Procedures Following Radiotherapy for Prostate Cancer.

Background And Purpose: Evidence on how treatment outcomes vary by patient characteristics helps to inform clinical practice. In this study, we measured socioeconomic and geographic disparity in post-radiotherapy procedures, as an indication of short-term radiotherapy adverse effects, among men with prostate cancer.

Materials And Methods: We studied 8344 South Australian diagnosed men with prostate cancer (2002-2020) who received external beam radiotherapy.

Efficacy of an online mindfulness program () to reduce fear of recurrence in people living with-and beyond-breast, prostate or colorectal cancer: a randomized controlled trial.

Background: Fear of cancer recurrence (FCR) is a prevalent and debilitating condition that effects around 60% of people living with cancer. It is severe, persistent, and imposes a significant financial burden on the healthcare system. Given FCR's profound impact on mental health and quality of life, adopting targeted interventions to mitigate its effects is essential.

Post-prostatectomy rehospitalisation rates and risk factors in South Australian men with prostate cancer: evidence from linked data.

Purpose: Prostate cancer is a common malignancy in men, with radical prostatectomy (RP) being a major treatment option. This study investigates post-prostatectomy rehospitalisation rates and risk factors in a cohort of South Australian men who underwent RP from 2002 to 2021 (n = 5105).

Methods: Post-prostatectomy rehospitalisation rates at 30 and 90 days were measured from hospital discharge data, with reasons determined from ICD-10 codes.

External Validation of MRI-Based Prostate Cancer Risk Calculators in an Australian Cohort.

Objective: To validate magnetic resonance imaging (MRI)-based prostate cancer risk calculators in an Australian population.

Methods: Data was retrospectively collected from patients biopsied at SALHN from May 2018 to March 2023. Men with MRI-suspicious lesions underwent biopsy.

The association of smoking with urinary and sexual function recovery following radical prostatectomy.

Objective: To investigate the association of smoking with post-prostatectomy functional recovery in a large population-based cohort using standardised outcome measures.

Patients And Methods: We conducted a cohort study and reported findings according to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines. We used a registry with prospectively gathered patient-reported outcome measures (PROMs) regarding health and morbidity.

Sexual wellbeing support for men with prostate cancer: a qualitative study with patients.

Background: Sexual concerns remain the most frequently reported unmet need among men with prostate cancer. We aimed to explore patient's experiences seeking and receiving sexual wellbeing support after prostate cancer treatment, to ultimately identify areas which should be prioritised for improvement, as informed by the patients themselves.

Methods: Prostate cancer patients between 18-36 months post-treatment participated in semi-structured interviews.

COVID-19 open data: An ecological study and international collaboration examining pandemic trends in Northern Periphery arctic countries.

In the early stages of the COVID-19 pandemic, evidence generation lagged behind public health responses. This study describes an international collaboration of frontline clinicians who used open data describing COVID-19 trends to generate "practice-based evidence". Open data resources from nine Northern Periphery and Arctic (NPA) countries were harnessed using the open-source programming language 'R' and our collaborations analyses and insights were published on a public-facing website.

Variation in Prostate Magnetic Resonance Imaging Performance: Data from the Prostate Biopsy Collaborative Group.

Background And Objective: The quality and reporting of prostate magnetic resonance imaging (MRI) are operator dependent, leading to variations in estimates such as positive predictive value across sites. This impacts patient counseling, risk modeling, and risk calculators. This study assessed variation in Prostate Imaging Reporting and Data System (PI-RADS) score classification and subsequent probability of grade group (GG) ≥2 + prostate cancer.

Radical cystectomy mortality in older patients: a systematic review and meta-analysis.

Objective: To perform a systematic review and meta-analysis of post-radical cystectomy (RC) mortality and complications in older people to aid decision-making pertinent to RC, as bladder cancer is typically a disease of older people, yet older people are less likely than their younger peers to undergo RC, predominantly due to concerns about morbidity and mortality of surgery.

Materials And Methods: A systematic search of MEDLINE, Scopus and Ovid Emcare was performed in May 2023 for all studies in the past 20 years that reported mortality and/or complications in the 90-days following RC. All studies reporting mortality or complication outcomes in patient groups aged >75 years were included.

Exploring sex-based differences in patient outcomes: A secondary analysis of Heartwatch, an Irish cardiovascular secondary prevention programme.

Background: In the last two decades, sex-related differences regarding cardiovascular diagnosis, treatment, and risk factors management have been reported. The current study aims to explore differences in cardiovascular outcomes among male and female patients attending the Irish secondary cardiovascular prevention programme - Heartwatch.

Methods: This is a retrospective observational study.

Impact of positive surgical margin location after radical prostatectomy: a network meta-analysis.

Objective: To perform a network meta-analysis comparing the impact of different positive surgical margin locations (Comparisons and intervention) on biochemical recurrence (Outcome) in patients undergoing radical prostatectomy (Population).

Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, a protocol was registered (PROSPERO: CRD42022119025) and a search across four databases was conducted (the MEDLINE, Scopus, Embase and Cochrane). The primary outcome was biochemical recurrence (BCR).

Predicting incontinence and erectile function after prostate cancer surgery: International validation of models.

Background: Our objective is to externally validate the most accurate, published tools predicting urinary incontinence and erectile dysfunction following prostatectomy. Several models have been developed to predict the risks of adverse events, though most have not been externally validated.

Methods: Data were obtained from the Prostate Cancer Outcomes Registry of Australia and New Zealand (PCOR-ANZ).

Use of erectile dysfunction treatments after prostate cancer treatment and their perceived impact on men's sex life: an analysis of patient reported outcome survey data.

Background: Although sexual dysfunction is a common treatment side-effect affecting men's quality of life, many prostate cancer patients do not receive or seek out treatments for erectile dysfunction (ED). The aims of this study are to investigate the extent and patterns of use of ED treatments and their perceived impact at different times following prostate cancer treatment.

Methods: This retrospective cohort study included all men on the South Australian prostate cancer registry who completed one or more Patient Reported Outcome Measures (PROMs) survey from 2016 to 2023 (n = 5561).

Comparing post-treatment urinary and colorectal procedures in prostate cancer patients using population-based linked data.

Purpose: To investigate urinary and colorectal procedures among men who underwent radical prostatectomy (RP) and external beam radiotherapy (EBRT).

Methods: We studied 16,271 (RP = 8516 and EBRT = 7755) South Australian men diagnosed with prostate cancer between 2001 and 2021. Colorectal and urinary procedures were extracted from hospital admission procedure codes and Medical Benefits Schedule item codes.

Genitourinary toxicity after pelvic radiation: Prospective review of complex urological presentations.

Objective: Recent randomised controlled trials underestimated the incidence of genitourinary (GU) complications occurring more than 5 years following pelvic radiotherapy. This study aimed to determine the burden of treatment at a single institution from late GU complications after pelvic radiotherapy.

Methods: A prospective study of all presentations for GU complications following pelvic radiotherapy at a tertiary urology department between November 2018 and November 2019 was performed.

Prognostic value of comorbidity measures among Australian men with non-metastatic prostate cancer.

Aim: To compare the utility of various admission-based comorbidity indices in men diagnosed with non-metastatic prostate cancer.

Methods: The study cohort consisted of men diagnosed with prostate cancer between January 2002 and December 2020 according to the state-wide South Australian Cancer Registry. Comorbid conditions were captured for 11,470 men through linkage to public hospital admission data 5-years prior to prostate cancer diagnosis.

Simulated GP clinic closure: effects on patient access in the Irish Mid-West.

Introduction: Rural communities can experience more barriers to accessing health care than their urban counterparts, largely due to fewer healthcare staff and services, and geographical isolation. The purpose of this study is to examine the availability of GP practices in rural communities across the Mid-West of Ireland and the potential impact of practice closure on patient access.

Methods: GP clinic locations were identified in Ireland's Mid-West, specifically counties Limerick and Clare.

Effects of COVID-19 on Irish general practice activity from 2019 to 2021: a retrospective analysis of 500,000 consultations using electronic medical record data.

Background: General practice (GP) is crucial to primary care delivery in the Republic of Ireland and is almost fully computerised. General practice teams were the first point of contact for much COVID-19-related care and there were concerns routine healthcare activities could be disrupted due to COVID-19 and related restrictions.

Aims: The study aimed to assess effects of the pandemic on GP activity through analysis of electronic medical record data from general practice clinics in the Irish Midwest.

Prostate Cancer Related Sexual Dysfunction and Barriers to Help Seeking: A Scoping Review.

Objective: Despite available support, sexuality needs are the most frequently reported unmet need among men with prostate cancer, which may be due to low help-seeking rates. Using the Ecological Systems Framework as a theoretical foundation, we conducted a scoping review of the available literature to understand what factors impact help-seeking behaviour for sexual issues after prostate cancer treatment among men who had received treatment.

Methods: Following PRISMA guidelines, a systematic search on Medline, PsychInfo, Embase, Emcare, and Scopus was conducted to identify studies of adult prostate cancer patients post-treatment, which reported barriers and/or facilitators to help-seeking for sexual health issues.

Temporal trends in medication and service use patterns for mental health issues among men with prostate cancer.

Objective: Prostate cancer can significantly impact mental wellbeing, creating uncertainty and morbidity. This study described patterns of psychotropic medication and mental health service use, as a proxy measure for mental health problems, 5 years before and 5 years after prostate cancer diagnosis.

Methods: Population-based registry data were linked with Pharmaceutical Benefits Scheme and Medicare Benefits Schedule data for all prostate cancer patients diagnosed in South Australia between 2012 and 2020 (n = 13,693).