Pressure tuning of competing interactions on a honeycomb lattice.

Exchange interactions are mediated via orbital overlaps across chemical bonds. Thus, modifying the bond angles by physical pressure or strain can tune the relative strength of competing interactions. Here we present a remarkable case of such tuning between the Heisenberg (J) and Kitaev (K) exchange, which respectively establish magnetically ordered and spin liquid phases on a honeycomb lattice.

A study on interoperability between two Personal Health Train infrastructures in leukodystrophy data analysis.

The development of platforms for distributed analytics has been driven by a growing need to comply with various governance-related or legal constraints. Among these platforms, the so-called Personal Health Train (PHT) is one representative that has emerged over the recent years. However, in projects that require data from sites featuring different PHT infrastructures, institutions are facing challenges emerging from the combination of multiple PHT ecosystems, including data governance, regulatory compliance, or the modification of existing workflows.

[Change in the age spectrum in strabismus surgery].

Background: The proportion of children undergoing strabismus surgery in the total volume of eye muscle operations appears to have decreased. To verify this we analyzed the age of patients who underwent extraocular muscle (EOM) surgery.

Methods: The data of patients who underwent EOM surgery at the University Eye Hospital Giessen between 1991 and 2019 were reviewed and the numbers of operations in decadal age groups were compared to the German population in the respective period.

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.

Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against . To ensure compound supply for further development, we studied myxovalargin biosynthesis in detail enabling production via fermentation of a native producer.

[High-dose medialis recession in latent nystagmus].

Background: Large muscle recessions reduce anomalous head turn (AHT) in infantile nystagmus syndrome (INS). Their quantitative effect to reduce AHT in fusion maldevelopment nystagmus syndrome (FMNS) is unknown.

Aim Of The Study: To evaluate the reduction of AHT by large medial rectus muscle recession in patients with FMNS.

Radio-Frequency Manipulation of State Populations in an Entangled Fluorine-Muon-Fluorine System.

Entangled spin states are created by implanting muons into single-crystal LiY_{0.95}Ho_{0.05}F_{4} to form a cluster of correlated, dipole-coupled local magnetic moments.

Application of leaf analysis in addition to growth assessment to evaluate the suitability of greywater for irrigation of Tilia cordata and Acer pseudoplatanus.

Water is the key resource in fulfilling the cooling function of plants in urban environments and needs to be supplied reliably and adequately, especially during dry periods. To avoid an unsustainable use of high-quality drinking water for irrigation, the reuse of greywater should be implemented for Green Infrastructure irrigation in the sense of the circular economy. In this study, the influence of greywater irrigation on vitality of two trees species, Tilia cordata and Acer pseudoplatanus, was determined by investigating the effect of irrigation with raw or treated greywater in comparison to municipal tap water.

First demonstration of tuning between the Kitaev and Ising limits in a honeycomb lattice.

Recent observations of novel spin-orbit coupled states have generated interest in 4/5 transition metal systems. A prime example is the [Formula: see text] state in iridate materials and α-RuCl that drives Kitaev interactions. Here, by tuning the competition between spin-orbit interaction (λ) and trigonal crystal field (Δ), we restructure the spin-orbital wave functions into a previously unobserved [Formula: see text] state that drives Ising interactions.

High-Frequency ac Susceptibility of Iron-Based Superconductors.

A microwave technique suitable for investigating the AC magnetic susceptibility of small samples in the GHz frequency range is presented. The method-which is based on the use of a coplanar waveguide resonator, within the resonator perturbation approach-allows one to obtain the absolute value of the complex susceptibility, from which the penetration depth and the superfluid density can be determined. We report on the characterization of several iron-based superconducting systems, belonging to the 11, 122, 1144, and 12442 families.

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics.

Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these antibiotics are known to interrupt translation at specific sequence motifs, with ketolides predominantly stalling at Arg/Lys-X-Arg/Lys motifs and macrolides displaying a broader specificity, a structural basis for their context-specific action has been lacking. Here, we present structures of ribosomes arrested during the synthesis of an Arg-Leu-Arg sequence by the macrolide erythromycin (ERY) and the ketolide telithromycin (TEL).

Yokoyama procedure for esotropia associated with high myopia: real-world data from a large-scale multicentre analysis.

Purpose: High myopic patients may develop strabismus due to globe dislocation out of the normal extraocular muscle cone. Surgical correction of this strabismus type is possible by joining the superior and lateral rectus muscles without the need for a scleral suture called the Yokoyama procedure. Data from large patient samples and the evaluation of a potential effect of an additional medial rectus recession (MRR) have been lacking so far.

[Bridle operation for incomplete oculomotor nerve paralysis (superior rectus and lateral rectus nasal inferior transposition)].

Purpose: To demonstrate the technique and effectiveness of the bridle operation for oculomotor nerve paralysis with maintained elevation.

Method: The bridle operation includes transposition of the lateral rectus muscle (passing behind inferior oblique and rectus muscles) and the superior rectus muscle (behind superior oblique tendon and medial rectus muscle) to the nasal inferior surface of the globe.

Results: In the reported case, this procedure corrected exo-hypertropia of 30-40°/20-30° without inducing cyclotropia.

Absence of local moments in the kagome metal KVSbas determined by muon spin spectroscopy.

We have carried out muon spin relaxation and rotation measurements on the newly discovered kagome metal KVSb, and find a local field dominated by weak magnetic disorder which we associate with the nuclear moments present, and a modest temperature dependence which tracks the bulk magnetic susceptibility. We find no evidence for the existence of Vlocal moments, suggesting that the physics underlying the recently reported giant unconventional anomalous Hall effect in this material warrants further studies.

[Three-muscle surgery for large angle esotropia].

Background: Bilateral medial rectus muscle recession with or without Cüppers' posterior fixation suture and recess and resect surgery are used to correct for large angle esotropia. There are only few reports on three muscle surgery (3MS). We analyzed the results of 3MS.

Microscopic Detection Analysis of Single Molecules in MoS Membrane Nanopores.

A systematic microscopic analysis of the various resistive effects involved in the electronic detection of single biomolecules in a nanopore of a MoS nanoribbon is presented. The variations of the transverse electronic current along the two-dimensional (2D) membrane due to the translocation of DNA and protein molecules through the pore are obtained by model calculations based on molecular dynamics (MD) and Boltzmann transport formalism, which achieved good agreement with the experimental data. Our analysis points to a self-consistent interaction among ions, charge carriers around the pore rim, and biomolecules.

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition.

T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines, identification of exact viral T cell epitopes is fundamental. Here we identify and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell epitopes in COVID-19 convalescent and unexposed individuals.

Bifunctional Nitrone-Conjugated Secondary Metabolite Targeting the Ribosome.

Many microorganisms possess the capacity for producing multiple antibiotic secondary metabolites. In a few notable cases, combinations of secondary metabolites produced by the same organism are used in important combination therapies for treatment of drug-resistant bacterial infections. However, examples of conjoined roles of bioactive metabolites produced by the same organism remain uncommon.

[Highly dosed Anderson and Kestenbaum operations for anomalous head posture due to nystagmus].

Background: The correction of anomalous head posture associated with infantile nystagmus syndrome (INS) is carried out by the Kestenbaum procedure (KP) combining bilateral horizontal yoke muscle recession with resection of their antagonists or by the Anderson procedure (AP) which is confined to yoke muscle recession alone.

Aim Of The Study: To compare the results of highly dosed AP and KP for anomalous head turn (HT).

Patients And Methods: The AP (2013-2019) and KP (2003-2013) were used as the exclusive procedures during the respective time periods.

Transverse Detection of DNA Using a MoS Nanopore.

Classical nanopore sensing relies on the measurement of the ion current passing through a nanopore. Whenever a molecule electrophoretically translocates through the narrow constriction, it modulates the ion current. Although this approach allows one to measure single molecules, the access resistance limits the spatial resolution.

Quality of Life After Total Mesorectal Excision and Rectal Replacement: Comparing Side-to-End, Colon J-Pouch and Straight Colorectal Reconstruction in a Randomized, Phase III Trial (SAKK 40/04).

Background: Functional outcomes of different reconstruction techniques have an impact on patients' quality of life (QoL), but information on long-term QoL is lacking. We compared QoL among three reconstruction techniques after total mesorectal excision (TME).

Methods: Quality of life was assessed within a randomized, multicenter trial comparing rectal surgery using side-to-end anastomosis (SEA), colon J-pouch (CJP), and straight colorectal anastomosis (SCA) by the Functional Assessment of Cancer Therapy-Colorectal scale (FACT-C) before randomization and every 6 months up to 2 years post-TME.

High-dose Anderson operation for nystagmus-related anomalous head turn.

Purpose: To evaluate the effectiveness of a high-dose Anderson procedure (AP) to correct infantile nystagmus-related anomalous head turn (HT).

Methods: Twenty-nine consecutive orthotropes with infantile nystagmus with and without associated sensory defect received high-dose AP. HT was measured while the patient tried to read letters at best-corrected visual acuity (BCVA) level at 5 m and 0.