Publications by authors named "Mercedes Stringer"
Cytopathology, crucial in disease diagnosis, commonly uses microscopic slides to scrutinize cellular abnormalities. However, processing high volumes of samples often results in numerous negative diagnoses, consuming significant time and resources in healthcare. To address this challenge, a surface acoustic wave-enhanced multi-view acoustofluidic rotation cytometry (MARC) technique is developed for pre-cytopathological screening.
View Article and Find Full Text PDFExtracellular vesicles (EVs) are secreted nanostructures that play various roles in critical cancer processes. They operate as an intercellular communication system, transferring complex sets of biomolecules from cell to cell. The concentration of EVs is difficult to decipher, and there is an unmet technological need for improved (faster, simpler, and gentler) approaches to isolate EVs from complex matrices.
View Article and Find Full Text PDFAcoustically accelerated neural differentiation of human embryonic stem cells.
Acta Biomater
October 2022
Article Synopsis
- Human embryonic stem cells (hESCs) have potential in targeted therapies and drug testing, but their differentiation into mature neurons is a slow process.
- An acoustic stimulator utilizing surface acoustic waves (SAWs) has been developed to enhance the speed of neuron production from hESCs, showing significant acceleration in neural differentiation.
- Research using RNA sequencing, qPCR, and immunostaining revealed changes in gene expressions and an increase in mature neuron markers while decreasing stem cell markers, confirming the effectiveness of SAW stimulation in promoting neural differentiation.