Paclitaxel-based strategy as first-line therapy for advanced breast cancer: a model-based economic evaluation for China.

Aim: The limited number of cost-utility studies of breast cancer conducted in China makes comparisons among different paclitaxel-based strategies difficult. To provide such data, a cost-utility analysis comparing albumin-bound formulation (nab)-paclitaxel (ABPTX), paclitaxel polymer micelles (PTXPM), and paclitaxel (PTX) for advanced breast cancer was performed.

Methods: Tree Age Pro 2011 software was used to simulate a Markov model to perform a health economic evaluation.

Estimating and forecasting global burden of mental disorders attributable to childhood sexual abuse or intimate partner violence: An analysis for the Global Burden of Disease Study 2021.

Background: As a leading global disease burden, mental disorders require critical assessment of related risk factors through disability-adjusted life years (DALYs) and years lived with disability (YLDs) to understand their public health impact.

Methods: With the data available from 2021 Global Burden of Disease (GBD), we mainly focused on the effect of childhood sexual abuse (CSA) and intimate partner violence (IPV) on global burden of mental disorders. We estimated numbers and the age-standardized rate (ASR) of DALYs/YLDs by sex, age, socio-demographic index (SDI), and country, and calculated the estimated annual percentage change (EAPC).

Circulating RIPK3 level predicts all-cause mortality in patients on maintenance hemodialysis: a 4-year prospective cohort study.

Background: Maintenance hemodialysis (MHD) is a well-established modality of renal replacement treatment for patients with end-stage renal disease. Currently, receptor-interacting protein kinase-3 (RIPK3) is considered as a key regulator of inflammation. But its association with mortality in MHD patients remains unclear.

METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.

N6-methyladenosine (m6A) is the most prevalent epitranscriptomic modification in mammalian mRNA. Recent studies have revealed that m6A modification is involved in cervical cancer (CC) pathogenesis, yet the precise mechanisms remain largely unexplored. In this study, we identified DDX5 as a binding partner of the methyltransferase METTL3 in CC cells, demonstrating that DDX5 interacts with METTL3 to regulate global m6A levels.

The association between vascular access satisfaction and all-cause mortality in maintenance hemodialysis patients.

Background: The mortality is significantly higher in patients undergoing maintenance hemodialysis (MHD) than in the general population. It is well-known that vascular access (VA) is critical for MHD patients. But the association between VA satisfaction and all-cause mortality in MHD patients is still not clear.

Inhibitory effect of aloperine on transient outward potassium currents in rat cardiac myocytes.

Objective: Aloperine (ALO) is an effective quinolizidine alkaloid. Previous research has demonstrated its antiarrhythmic effect by inhibiting voltage-gated sodium currents in rat ventricular myocytes. This study explored its effect on transient outward potassium currents (I) in rat atrial myocytes to identify potential targets in the context of ion channel currents.

Self-Catalyzed Synthesis of Length-Controlled One-Dimensional Nickel Oxide@N-Doped Porous Carbon Nanostructures from Metal Ion Modified Nitrogen Heterocycles for Efficient Lithium Storage.

Transition metal oxides with the merits of high theoretical capacities, natural abundance, low cost, and environmental benignity have been regarded as a promising anodic material for lithium ion batteries (LIBs). However, the severe volume expansion upon cycling and poor conductivity limit their cycling stability and rate capability. To address this issue, NiO embedded and N-doped porous carbon nanorods (NiO@NCNR) and nanotubes (NiO@NCNT) are synthesized by the metal-catalyzed graphitization and nitridization of monocrystalline Ni(II)-triazole coordinated framework and Ni(II)/melamine mixture, respectively, and the following oxidation in air.

Clinical characteristics, diagnosis and management of nivolumab-induced myocarditis.

Nivolumab can cause fatal myocarditis. We aimed to analyze the clinical characteristics of nivolumab-induced myocarditis and provide evidence for clinical diagnosis, treatment, and prevention. Studies involving nivolumab-induced myocarditis were identified in electronic databases from 2000 to 2023 for retrospective analysis.

Intrathecal or intraventricular antimicrobial therapy for post-neurosurgical Gram-negative bacillary meningitis or ventriculitis: a systematic review and meta-analysis.

Purpose: Extensively-drug-resistant Gram-negative bacteria (XDR GNB)-related post-neurosurgical infection is closely related to mortality, which represents a major challenge for neurosurgeons. There is an urgent need to review and evaluate methods to reduce mortality.

Methods: Both international and Chinese databases were searched independently from their inception to 15 June 2023.

[Advances in pharmacological effects of jujuboside B].

Ziziphi Spinosae Semen(ZSS) is an edible TCM derived from the dried ripe seeds of Ziziphus jujube Mill. var. spinosa(Bunge)Hu ex H.

Investigating Psychological Motivations to Use Online Physical Learning: A Theoretical Study in the Dance Education.

Introduction: Online education has become increasingly popular during the COVID-19 pandemic. Despite its potential for breaking down environmental, geographic, time, and space constraints, many scholars have found that online education still has much room for development. Online physical education, and especially dance education, face challenges due to the high demands of physical interactions and safety requirements.

[Content determination of seven active components of Eucommiae Cortex in aortic vascular endothelial cells of spontaneously hypertensive rats by UPLC-MS/MS].

In the present study, the contents of seven active components [genipinic acid(GA), protocatechuic acid(PCA), neochlorogenic acid(NCA), chlorogenic acid(CA), cryptochlorogenic acid(CCA),(+)-pinoresinol di-O-β-D-glucopyranosid(PDG), and(+)-pinoresinol 4'-O-β-D-glucopyranoside(PG)] of Eucommiae Cortex in aortic vascular endothelial cells of spontaneously hypertensive rats(SHR) were simultaneously determined by ultra-high liquid chromatography-triple quadrupole mass spectrometry(UPLC-MS/MS). The qualified SHR models were selected. The primary aortic endothelial cells(VECs) of rats were separated and cultured by ligation and adherence, followed by subculture.

Development and economic assessment of machine learning models to predict glycosylated hemoglobin in type 2 diabetes.

Glycosylated hemoglobin (HbA1c) is recommended for diagnosing and monitoring type 2 diabetes. However, the monitoring frequency in real-world applications has not yet reached the recommended frequency in the guidelines. Developing machine learning models to screen patients with poor glycemic control in patients with T2D could optimize management and decrease medical service costs.

Huzhangqingmaiyin protected vascular endothelial cells against cerebral small vessel disease through inhibiting inflammation.

Ethnopharmacological Relevance: Huzhangqingmaiyin (HZQMY) is a Chinese medicine formula used to treat small vessel disease, but the mechanism is unclear.

Aim Of The Study: This study aimed to reveal the protective effects of HZQMY on human brain microvascular endothelial cells (HBMECs) and explore the potential targets and mechanistic pathways using network pharmacology on treating cerebral small vessel disease (CSVD).

Materials And Methods: HBMECs were cultured in vitro and an endothelial cell injury model was constructed by hypoxia for 12 h followed by reoxygenation for 8 h (H/R).

3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage.

Chronic cerebral hypoperfusion is an important pathological factor in many neurodegenerative diseases, such as cerebral small vessel disease (CSVD). One of the most used animal models for chronic cerebral hypoperfusion is the bilateral common carotid artery stenosis (BCAS) mouse. For the therapy of CSVD and other diseases, it will be beneficial to understand the pathological alterations of the BCAS mouse, particularly vascular pathological changes.

Regional abnormalities of spontaneous brain activity in migraine: A coordinate-based meta-analysis.

Many resting-state functional magnetic resonance imaging (rs-fMRI) studies have explored abnormal regional spontaneous brain activity in migraine. However, these results are inconsistent. To identify the consistent regions with abnormal neural activity, we meta-analyzed these studies.

Burden of gastroesophageal reflux disease in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of disease study 2019.

Introduction: For effective preventive strategies against GORD (gastro-esophageal reflux disease), we assessed the GORD burden from 1990 to 2019.

Methods: The burden of GORD between 1990 and 2019 was evaluated globally, regionally, and nationally. Using ASIR (age-standardized incidence), ASYLDs (age-standardized years lived with disabilitys), we compared them to the GBD world population per 100,000.

The impact of vascular access satisfaction on health-related quality of life in patients receiving maintenance hemodialysis: A 2-year follow-up study.

Background: Health-related quality of life (HRQoL) has been demonstrated to predict mortality in patients receiving maintenance hemodialysis (MHD). Vascular access (VA) is critical for MHD patients. The aim of this study was to investigate the change in HRQoL among MHD patients with a 2-year follow-up and to explore the impact of VA satisfaction on HRQoL in this population.

Advances for pharmacological activities of - A review.

Context: Sieb. et Zucc (Polygonaceae), the root of which is included in the Chinese Pharmcopoeia under the name 'Huzhang', has a long history as a medicinal plant and vegetable. has been used in traditional Chinese medicine for the treatment of inflammation, hyperlipemia, etc.