Publications by authors named "Megan Paterson"

Introduction: With the increasing use of aeromedical transport for critically ill patients, it is essential to understand the impact of pressure changes on drug infusion delivery systems. As airplanes ascend and descend, gases/bubbles are released from solutions when ambient pressure decreases and dissolves when pressure increases. This may affect mechanical fluid delivery systems and cause clinically significant changes, especially within a critical care setting.

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Triaging is an important step in deciding which items collected from crime scenes to select for forensic analysis, and so subsequent examination and findings often depend on it. This study aims to evaluate the influence of casework pressures and tolerance to ambiguity on triaging of items collected from a crime scene. A realistic pressure manipulation paradigm was developed and was found to be effective in inducing feelings of pressure in participants in an online setting.

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The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This chapter builds on the 2022 ISPAD guidelines, and updates recommendations on the principles of intensive insulin regimens, including more intensive forms of multiple daily injections with new-generation faster-acting and ultra-long-acting insulins; a summary of adjunctive medications used alongside insulin treatment that includes details on pramlintide, metformin, glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RA) and sodium-glucose cotransporter inhibitors; and key considerations with regard to access to insulin and affordability to ensure that all persons with diabetes who need insulin can obtain it without financial hardship.

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Introduction: With the increasing use of aeromedical transport for critically ill patients, it is essential to understand the impact of pressure changes on drug infusion delivery systems. As airplanes ascend and descend, gases/bubbles are released from solutions when ambient pressure decreases and dissolves when pressure increases. This may affect mechanical fluid delivery systems and cause clinically significant changes, especially within a critical care setting.

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Introduction: Young adulthood is well documented as being a particularly challenging area of type 1 diabetes (T1D) healthcare. Many young adults with T1D (YAT1D) are distracted from effective disease self-management; T1D healthcare service engagement can be problematic and inconsistent, and high rates of unplanned healthcare contacts prevail. Video conferencing use can facilitate services to be flexible and responsive.

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Article Synopsis
  • - The study explores how atmospheric pressure changes during flights can influence insulin delivery from pumps in people with type 1 diabetes, potentially leading to issues like hypoglycaemia.
  • - An in vitro flight simulation mimicking airline conditions revealed that insulin pumps can over-deliver and under-deliver insulin at different stages of flight, particularly significant during emergency decompression scenarios.
  • - Real-world data from pilots using continuous subcutaneous insulin infusion (CSII) showed that insulin levels remained stable with only a small percentage of blood glucose readings falling outside the safe range, indicating effective management while flying.
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Problem: Children with Type 1 Diabetes (T1D) spend a large amount of time at school. Subsequently, school staff often need education around T1D management to optimise related outcomes. Education is particularly essential in primary school settings, due to lack of independence.

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Dysphagia is common in motor neurone disease (MND) and associated with negative health and psychosocial outcomes. Although largely considered a motor disease, a growing body of evidence suggests that MND can also affect the sensory system. As intact sensation is vital for safe swallowing, and sensory changes can influence the clinical management of dysphagia in people living with MND, this review evaluated and summarised the current evidence for sensory changes related to swallowing in MND.

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Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection.

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Article Synopsis
  • Rhodococcus equi, a bacterium causing severe pneumonia in foals and emerging as a human pathogen, shows significant genomic conservation, with a study analyzing a novel bovine isolate (B0269) revealing unique genetic features.
  • The analysis highlighted a pangenome of 6,876 genes, with 2,875 genes specific to the bovine isolate, indicating possible adaptations, including genes potentially involved in chemical stress responses.
  • Despite identifying similarities in plasmid structures related to virulence, key virulence genes were absent in B0269, suggesting the need for further research to fully understand the isolate's virulence potential.
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A primary focus of the management of type 1 diabetes has been on matching prandial insulin therapy with carbohydrate amount consumed. However, even with the introduction of more flexible intensive insulin regimes, people with type 1 diabetes still struggle to achieve optimal glycaemic control. More recently, dietary fat and protein have been recognised as having a significant impact on postprandial blood glucose levels.

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Introduction: Insulin pumps are able to deliver bolus insulin as a standard, extended or combination bolus. There is minimal research to determine which bolus is preferable in different settings. Anecdotally, many patients utilizes only the standard bolus (SB) due to uncertainty regarding when and how to program the different bolus types.

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Objective: Children and adults with type 1 diabetes who receive insulin pump therapy have reported hypoglycemia during air travel. We studied the effects of atmospheric pressure on insulin pump delivery.

Research Design And Methods: Ten insulin pumps were connected to capillary tubes.

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Objective: The purpose of the study was to evaluate a new rural Australian multidisciplinary model of pediatric diabetes care.

Methods: In 2007, in response to insurmountable obstructions to establish an effective multidisciplinary team within the public health system, an Australian rural pediatric practice created a private multidisciplinary diabetes care model. The 'Rural Australian Diabetes -Inspiring Control Activity & Lifestyle' model -'RADICAL'-comprised a locally based, co-located core team of general pediatrician, diabetes educator, and mental health nurse.

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