High-Resolution Roll-to-Roll Additive Patterning of Functional Materials on Large Areas via Topographic Discontinuous Dewetting.

Two-dimensional (2D) arrays of nanoscale functional materials are essential for the advancement of cutting-edge technologies in optics and photonics, optoelectronics, and sensor systems. Conventional fabrication techniques for these structures, however, are limited by high energy consumption, significant waste, and scalability challenges. To address these issues, we demonstrate a roll-to-roll (R2R) additive nanopatterning process, offering a sustainable and scalable solution for large-area, high-resolution production of 2D metamaterials.

The F-box protein gene - is a target for reverse engineering enzyme hypersecretion in filamentous fungi.

Carbohydrate active enzymes (CAZymes) are vital for the lignocellulose-based biorefinery. The development of hypersecreting fungal protein production hosts is therefore a major aim for both academia and industry. However, despite advances in our understanding of their regulation, the number of promising candidate genes for targeted strain engineering remains limited.

Effective Targeting of TAG72 Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells.

Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expression of tumor-associated antigens, as well as limited T cell persistence and/or tumor trafficking pose major challenges for successful translation of CAR T cell therapy in solid tumors. Recent studies have demonstrated that aberrantly glycosylated cell surface proteins on tumor cells are amenable CAR targets.