Characterization of dietary fiber and soluble carbohydrates in date fruits (Phoenix dactylifera L.).

Understanding the physicochemical and structural properties of the dietary fiber present in date fruits is useful for its onward processing for food and non-food applications. This research fractionated dietary fiber from four date fruit cultivars into soluble and insoluble fractions and studied their structural features and physicochemical and thermal properties. Total dietary fibers content ranged 3.

Enhanced selective gold recovery from e-waste synergistic hetero-atom controlled quasi-planar benzoxazine-based covalent organic frameworks.

Efficient and selective gold recycling from e-waste mixtures is crucial for advancing sustainability, the circular economy, and waste management objectives. However, the complex composition of e-waste and the underdeveloped practical potential of current adsorbents highlight the need for innovative sorbent development. Here, we present quasi-planar, benzoxazine-core-based two-dimensional covalent organic frameworks (COFs) with synergistic hetero-atom control across the network, achieved a multi-component synthetic approach.

The Impact of Fontan Circulatory Failure on Heart Transplant Survival: A 20-Center Retrospective Cohort Study.

Background: Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality rates, including heart failure, multisystem end-organ disease, and need for heart transplant. Specific FCF morbidities have not been rigorously defined, limiting study of how FCF morbidities affect pre-heart transplant and post-heart transplant outcomes. We hypothesized that FCF-related morbidities affect survival from heart transplant waitlisting through 1 year after heart transplant.

Rehabilitation in children with ventricular assist devices.

Ventricular assist devices play a critical role in the management of end-stage heart failure, with a significant increase in their utilization in children over the past 20 years. While much attention has been given toward the success of ventricular assist devices in reversing the physiologic consequences of chronic heart failure, the ability of ventricular assist devices to facilitate rehabilitation should not be underestimated. For patients with chronic heart failure, rehabilitation can be understood to include exercise rehabilitation, nutritional rehabilitation, and psychosocial rehabilitation.

Improving pediatric heart failure outcomes through collaboration and innovation: The current status of the Advanced Cardiac Therapies Improving Outcomes Network (ACTION).

The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) was founded in 2017 as a learning health care system to bring together all stakeholders with the aim of improving outcomes for pediatric and congenital heart disease patients with heart failure. From an initial focus on the ventricular assist device (VAD) population, work in the network has expanded to encompass the scope of heart failure in these patients. Through the collection and use of real-world data, the field has gained greater understanding of best practices in care of these patients, as well as improved access to devices with pediatric labeling of devices previously approved only for adults.

Contemporary outcomes of mechanical circulatory support using paracorporeal continuous flow pump in children: A report from the ACTION learning network.

Background: This study aims to evaluate the clinical outcomes of mechanical circulatory support (MCS) using paracorporeal continuous flow (pCF) pumps in children.

Methods: This multicenter retrospective study used the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) database (4/2018-7/2023). Children who were supported with a pCF pump were included.

Impact of Neighborhood Factors on Exercise Capacity in Children With Hypertrophic Cardiomyopathy.

Background: Restricting certain patients with hypertrophic cardiomyopathy (HCM) from exercise likely has negative cardiovascular effects and has not been shown to reduce the risk of sudden cardiac death. Promoting exercise in children with HCM is complex and requires knowledge of the environmental factors that impact exercise capacity in children with HCM.

Methods: This retrospective, cross-sectional analysis includes children with HCM who underwent exercise stress testing at a single, children's tertiary-care center between 2000 and 2023.

Long-Term Survival and Patient-Reported Outcomes After Staged Reconstructive Surgery for Hypoplastic Left Heart Syndrome.

Background: Survival for hypoplastic left heart syndrome (HLHS) and variants has improved over the past 4 decades; however, survival remains low compared with other forms of congenital heart disease. There is a paucity of data concerning long-term outcomes.

Objectives: This study aims to: 1) examine long-term survival and the impact of patient factors on survival for newborns with HLHS; and 2) examine functional and health outcomes, including quality-of-life (QOL) in adulthood.

Multi-institutional outcomes of Impella use in pediatric patients: A brief communication from the ACTION Network.

This retrospective cohort study includes 150 pediatric patients supported with the Impella between April 2018 and November 2024. Median weight was 62.9 kg (interquartile range [IQR] 51.

A comprehensive nomenclature system for cyclodextrins.

Modified cyclodextrins (CDs) are cyclic oligosaccharides with many applications in drug delivery, catalysis, and as active pharmaceutical ingredients. In general, they exist as distributions of structurally diverse molecules rather than single-isomer compounds. Their performance depends on the number of glucopyranose units (GPUs), and the type, number, and position of chemical substitutions in their hydroxyl groups.

Ventricular Assist Device Use in Pediatric Restrictive and Hypertrophic Cardiomyopathy: An ACTION Registry Analysis.

The use of ventricular assist devices (VADs) in children with restrictive (RCM) and hypertrophic cardiomyopathy (HCM) remains rare. We describe the outcomes of patients with RCM and HCM supported by VAD in the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) registry from March 2012 to December 2024. Thirty-four patients were identified: 20 left-sided VAD (LVAD), 13 biventricular VAD (BiVAD), and 1 total artificial heart (TAH).

Selective removal of 7-ketocholesterol by a novel atherosclerosis therapeutic candidate reverts foam cells to a macrophage-like phenotype.

Background And Aims: The removal of the toxic oxidized cholesterol, 7-ketocholesterol (7KC), from cells through the administration of therapeutics has the potential to treat atherosclerosis and various other pathologies. While cholesterol is a necessary building block for homeostasis, oxidation of cholesterol can lead to the formation of toxic oxysterols with 7KC being the most prominent. 7KC is primarily formed through the non-enzymatic oxidation of cholesterol and is found in high levels in oxidized LDL (oxLDL) particles, which are highly implicated in heart disease.

Healthcare Professional Perspectives on Digital Health-Related Quality-of-Life Assessment in Paediatric Radiation Therapy: A Qualitative Study.

Introduction: Health-related quality of life (HRQoL) is not routinely evaluated using patient-reported outcome measures (PROMs) in paediatric radiation therapy (RT). This study aimed to identify barriers and facilitators to HRQoL implementation in paediatric RT clinical practice and requirements for a digital PROM platform, from the perspectives of healthcare professionals.

Method: Exploratory semi-structured interviews were conducted with multidisciplinary clinicians from two hospitals providing care to paediatric RT patients.

Identifying the determinants of health-related quality of life in children after heart transplant.

Background: Pediatric heart transplant (PHT) recipients have impaired health-related quality of life (HRQOL) that is not fully explained by cardiac limitations. Environment is known to influence HRQOL in other chronic disease populations but is less understood in PHT. Understanding the determinants of HRQOL is a necessary step in identifying high-risk groups and designing actionable interventions.

SPHENISCID ALPHAHERPESVIRUS 1 IN AFRICAN PENGUINS () WITHIN THE SPECIES SURVIVAL PLAN MANAGED POPULATION IN THE US: INCIDENCE AND POPULATION IMPACT.

Spheniscid alphaherpesvirus-1 (SpAHV-1) is associated with respiratory disease in juvenile African penguins (). In 2020, this virus was detected in adult birds with clinical signs of respiratory disease in a previously asymptomatic colony of 21 birds following a recommended introduction of three new birds, including two with a history of herpesvirus as juveniles. Mild to moderate respiratory signs were noted in 33% (8/24) of the colony.

Returning raw genomic data to research participants in a pediatric cancer precision medicine trial.

In pediatric cancer precision medicine clinical trials settings, parents proactively seeking treatment and answers to causation may request return of their child's raw data and/or biospecimen. To satisfy such requests, the ZERO Childhood Cancer Program required a guidance document. Literature review led to Version(V)1; Delphi consultation with 21/54 invited experts (V2-4) and parent consultations (V5-6).

Long-Term Survival in Children Following Heart Transplantation.

Background: Short-term outcomes following heart transplantation in children have improved, but comparable improvements in long-term survival continues to have barriers. We sought to investigate long-term outcomes following heart transplantation and to identify protective and risk factors associated with long-term survival in children.

Methods: The Pediatric Heart Transplant Society (PHTS) database was queried for heart transplant recipients from 1993 to 2010 who were ≤ 10 years of age at time of transplant.

The ACTION VAD registry: A collective five-year experience.

Background: The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) began in 2018 as a collaborative learning health system committed to improving outcomes in pediatric heart failure, including children and adults with congenital heart disease, supported with ventricular assist devices (VADs). This report describes patient and device characteristics, and outcomes through 1-year post-implant.

Methods: The ACTION VAD registry report was created from data submitted to the ACTION learning network from April 2018 to June 2023.

Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy.

Background: The United Network of Organ Sharing made changes to the priority for allocation of hearts for transplantation in 2016 for pediatric patients and 2018 for adult patients. Although recent work has evaluated the impact of the revised allocation systems on mechanical circulatory support practices and waitlist outcomes, there are limited data that focus more specifically on the impact of the allocation changes on patients with congenital heart disease (CHD) or cardiomyopathy and how these relationships might differ in pediatric and adult patients.

Methods: The United Network of Organ Sharing database was queried for pediatric (<18 years of age) and adult (18-50 years of age) patients with a CHD or cardiomyopathy diagnosis listed for heart transplantation.

Outcomes for Children With Congenital Heart Disease Undergoing Ventricular Assist Device Implantation: An ACTION Registry Analysis.

Background: There are no contemporary reports that highlight the national outcomes for children with congenital heart disease (CHD) undergoing ventricular assist device (VAD) implantation.

Objectives: This study sought to evaluate differences in VAD outcomes for children with CHD to those with non-CHD as well as those with univentricular CHD to those with biventricular CHD.

Methods: Data for CHD and non-CHD patients from the multicenter ACTION (Advanced Cardiac Therapies Improving Outcomes Network) undergoing VAD implantation from April 2018 to February 2023 were included.