Publications by authors named "Matthew Adesuyan"
Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) are first-line antihypertensive drugs for many patients, and influencing angiotensin systems may play a role in dementia risk. This study aimed to investigate whether exposure to different antihypertensive drug classes compared with ACEI affects the risk of dementia and pathological dementia subtypes in a large multinational database study.
Methods: This was a multinational population-based cohort study using electronic health databases in Hong Kong, the UK, Sweden and Australia.
Aims: To compare the effects of low-dose aspirin and clopidogrel on the risk of incident type 2 diabetes among patients with ASCVD.
Methods: This target trial emulation study was performed usingthe IQVIA Medical Research Data UK primary care database, including adults with an incident first ASCVD event who initiated low-dose aspirin or clopidogrel between 2004 and 2021. We applied an overlap weighting approach to balance treatment groups.
Background: Effective hypertension management requires medication adherence to prevent complications. However, adverse drug reactions (ADRs) can undermine adherence and negatively affect patients' quality of life. Limited research has explored the association between ADRs, medication adherence, and health-related quality of life (HRQoL) in individuals with hypertension.
View Article and Find Full Text PDFUnlabelled: In a population-based cohort study of menopausal women with common mental health diagnoses, SSRIs/SNRIs were associated with a 32% increased risk of osteoporotic fractures. The risk of osteoporotic fractures was particularly increased for longer periods of treatment with SSRIs/SNRIs (> 5 years) and in younger menopausal women (< 50 years old).
Purpose: To investigate the association between selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and the risk of osteoporotic fractures (OF) in menopausal women with common mental health diagnoses (CMHD).
Article Synopsis
- Women aged 45-54 have significantly higher rates of common mental health disorders (depression and anxiety) compared to men in the same age group, with incidence ratios showing more than 1.5 times the prevalence in women.
- The study analyzed prescription rates for antidepressants, finding that SSRIs and SNRIs were the most commonly prescribed medications, with women receiving more prescriptions than men in 2021.
- The research highlights that menopausal transition may contribute to increased mental health issues in older women, but it also notes limitations in accurately tracking menopause onset in medical records.
Background And Objectives: Repurposing phosphodiesterase type 5 inhibitors (PDE5Is) as drugs for Alzheimer disease (AD) risk reduction has shown promise based on animal studies. However, evidence in humans remains inconclusive. Therefore, we conducted a cohort study to evaluate the association between PDE5I initiation compared with nonuse and the risk of developing AD in men with erectile dysfunction (ED).
View Article and Find Full Text PDFBackground: Adverse drug reaction (ADR) related to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may negatively affect patients' treatment outcomes.
Aim: To investigate the impact of ACEIs/ARBs-related ADR consultation on cardiovascular disease (CVD) events and all-cause mortality.
Design And Setting: Propensity score-matched cohort study of ACEIs/ARBs between 2004 and 2019 using UK IQVIA medical research data.
Trends in the incidence of dementia in people with hypertension in the UK 2000 to 2021.
Alzheimers Dement (Amst)
July 2023
Introduction: We investigated trends in the incidence of dementia in UK adults with hypertension.
Methods: Primary care electronic health records from IQVIA Medical Research Data UK, previously known as THIN, were used to identify 2,133,118 adults aged ≥40 years with hypertension over 2000 to 2021. The annual incidence rate and average annual percentage change in recorded dementia diagnoses were estimated and stratified by sex, 10-year age bands, Townsend deprivation quintiles and dementia subtype.
Background: Recent studies on the prescribing of hormone replacement therapy (HRT) medicines to treat symptoms of menopause are lacking.
Aim: To describe the prescribing of HRT in a cohort of UK menopausal women.
Design & Setting: Population-based drug utilisation study using IQVIA Medical Research Database (IMRD-UK).