Publications by authors named "Matthew A Moss"
Pregnancy reprograms mammary epithelial cells (MECs) to control their responses to pregnancy hormone re-exposure and carcinoma progression. However, the influence of pregnancy on the mammary microenvironment is less clear. Here, we used single-cell RNA sequencing to profile the composition of epithelial and non-epithelial cells in mammary tissue from nulliparous and parous female mice.
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- - Oxytocin (OXT) is commonly used during labor, but its effects on the developing brain are not well understood; this study examines how maternal OXT administration influences gene expression in mouse brains during the perinatal period.
- - Pregnant mice received either saline or OXT at term, and gene expression analyses showed distinct patterns in the brains of their offspring, with notable differences based on the sex of the pups, particularly in females.
- - The results indicate that prenatal exposure to OXT leads to significant changes in the expression of several nervous system-related genes, suggesting that OXT may have a crucial role in brain development during this critical period.
Myeloid cell heterogeneity remains poorly studied in breast cancer, and particularly in premalignancy. Here, we used single cell RNA sequencing to characterize macrophage diversity in mouse pre-invasive lesions as compared to lesions undergoing localized invasion. Several subpopulations of macrophages with transcriptionally distinct profiles were identified, two of which resembled macrophages in the steady state.
View Article and Find Full Text PDFPregnancy causes a series of cellular and molecular changes in mammary epithelial cells (MECs) of female adults. In addition, pregnancy can also modify the predisposition of rodent and human MECs to initiate oncogenesis. Here, we investigate how pregnancy reprograms enhancer chromatin in the mammary epithelium of mice and influences the transcriptional output of the oncogenic transcription factor cMYC.
View Article and Find Full Text PDFIn mammary gland development, normal stem cell activity occurs in the embryonic stage and postnatally. Research supports that certain breast cancers contain a small sub-population of cells that mimic stem-like activity. It is believed stem cell activation in the mutated mature human mammary tissue is what drives quiescent epithelial cells to convert to mesenchymal states initiating migration, invasion, and metastasis in breast cancer.
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