Publications by authors named "Matthew A Crystal"

Intravascular stenting in congenital heart disease (CHD) is a treatment modality that must account for patient somatic growth and future re-intervention. Stent expansion and intentional fracture can be performed safely and effectively. Limited understanding and data exist for drug-eluting coronary stents (DES).

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Background: Technical success (TS) and procedural safety (PS) have been reported individually for transcatheter atrial septal defect (ASD) and patent ductus arteriosus (PDA) closures. A composite procedural performance (PP) metric as a patient-centered strategy has not been developed or studied.

Methods: A multicenter expert working group created PP metrics for ASD and PDA device closures as a composite of TS and PS.

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We describe the use of a total artificial heart (TAH) (Syncardia) as a successful bridge to transplantation in a pediatric patient. The post-TAH course included obstruction of both systemic veins with decreased TAH filling and output that was successfully treated with bicaval stent placement. After stenting of the systemic veins, the patient was able to successfully rehabilitate and underwent successful cardiac repeated transplantation 6 months after TAH placement.

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Background: Covered stent correction for a sinus venosus atrial septal defect (SVASD) was first performed in 2009. This innovative approach was initially viewed as experimental and was reserved for highly selected patients with unusual anatomic variants. In 2016, increasing numbers of procedures began to be performed, and in several centers, it is now offered as a standard of care option alongside surgical repair.

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Background: Safety events and technical success (TS) have been previously reported for aortic and pulmonary valvuloplasty, but a composite performance measure as a novel, patient-centered strategy has neither been developed nor been studied. This study aims to refine a procedural performance (PP) variable, a composite of TS and procedural safety, for isolated, standard-risk aortic and pulmonary valvuloplasty.

Methods: A multicenter review was performed using data from the Congenital Cardiac Catheterization Project on Outcomes registry.

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Article Synopsis
  • The study investigates the safety and outcomes of simultaneous stent placement for pulmonary artery (PA) bifurcation stenosis in infants under 12 months of age.
  • A total of 17 infants were reviewed, with significant improvements in key measurements like pressure gradients and vessel diameter post-procedure, though some experienced severe adverse events.
  • The findings suggest that while simultaneous stent placement is effective, ongoing transcatheter interventions will be needed for growth management and to postpone re-operations.
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Pulmonary vein stenosis (PVS) in children is a challenging condition with poor outcomes. Post-operative stenosis can occur after repair of anomalous pulmonary venous return (APVR) or stenosis within native veins. There is limited data on the outcomes of post-operative PVS.

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  • The study assesses the durability of the Inspiris Resilia prosthesis as a surgical pulmonary valve replacement (PVR) compared to non-Inspiris options, focusing on performance data from patient surgeries between 2018 and 2022.
  • Results show that the Inspiris valve group had significantly lower rates of freedom from valve failure and moderate pulmonary regurgitation after two years compared to non-Inspiris patients, highlighting concerns over its performance.
  • The findings suggest that the Inspiris valve performs worse when implanted in the native right ventricular outflow tract versus as a conduit, indicating that different techniques or alternative valves may be necessary for better outcomes.
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  • Right ventricular (RV) dysfunction is a key factor in poor health outcomes for patients with tetralogy of Fallot (TOF), and this study focuses on tracking RV function via global longitudinal strain (GLS) in patients with ductal-dependent TOF after surgical repair.
  • The study analyzed 44 patients who either underwent primary or staged surgical repair, measuring RV GLS at various points: pre-operatively, right after surgery, and at ages 1 and 2.
  • Over time, RV GLS showed improvement post-repair; however, patients still had lower GLS compared to healthy age-matched controls, and there was no significant difference in GLS between the two types of surgical approaches at the 2-year follow-up.
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  • The study conducted a meta-analysis on the outcomes of Ross/Ross-Konno procedures in neonates and infants, adhering to PRISMA guidelines and using various databases to gather relevant studies.
  • The analysis included 587 patients and discovered an early mortality rate of 18.3% and a late mortality rate of 9.7%, with significant variability in outcomes among the studies.
  • The findings indicate a notable risk associated with these procedures, emphasizing the need for skilled surgical practices and careful selection of patients, along with the call for further multicenter research.
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  • Pulmonary artery thromboembolism is a prevalent and manageable cause of pulmonary hypertension in adults, but it is less common in children and can lead to serious health issues if not diagnosed.
  • The report discusses a case involving a newborn with cyanosis who was discovered to have blood clots (thrombi) in both pulmonary arteries.
  • The neonate successfully received thrombolysis treatment with tissue plasminogen activator, which quickly alleviated the high blood pressure in the right side of the heart.
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  • A study analyzed the safety of transcatheter device closure for patent ductus arteriosus (PDA) in 33 children with pulmonary artery hypertension, revealing a successful implantation in all patients.
  • The median follow-up was about 17 months, with a notable number of complications occurring in 9.1% of cases, mostly related to device placement issues.
  • The results indicated that PDA closure can improve symptoms in children, especially those born prematurely, and highlighted the need for larger studies to further validate these findings.
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Introduction: Pulmonary atresia with the ventricular septal defect is a rare congenital heart defect with high anatomic variability. The most important management question relates to the sources of pulmonary blood flow. The ability to differentiate between ductal dependence and major aortopulmonary collateral arteries is critical to achieving good outcomes and avoiding life-threatening hypoxia in the postneonatal period.

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  • COVID-19 prompted hospitals worldwide to postpone elective surgeries to reduce viral spread and conserve resources, particularly affecting pediatric catheterization procedures.
  • This study reviewed 52 catheterizations done between March 16 and May 10, 2020, focusing on case selection, workflow changes, and COVID-19 testing results.
  • Results showed that most procedures were on patients testing negative for COVID-19, with an emphasis on prioritizing urgent cases, highlighting strategies that can help other centers adapt during the ongoing pandemic.
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Article Synopsis
  • - The COVID-19 pandemic has significantly impacted pediatric cardiac catheterization practices in the US, leading to the cancellation of elective procedures nationwide.
  • - A survey of 56 centers revealed a consensus on which procedures are elective, with higher involvement in PPE training at facilities in areas with more COVID-19 cases.
  • - The findings guide resource allocation and strategies for pediatric cardiac programs to adapt to the challenges posed by the pandemic and ensure patient care continues effectively.
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  • Severe aortic stenosis (AS) in infants can lead to increased pressure on the left ventricle but often does not show reduced ejection fraction, making strain analysis important for assessing heart function.
  • In a study of 27 infants who underwent balloon aortic valvuloplasty (BAV), significant improvement in global longitudinal strain was noted after the procedure, indicating better heart performance.
  • Despite improvements, 20% of patients required further interventions, showing some persistence of pressure gradients even after BAV.
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  • Advances in fetal echocardiography enable early detection of congenital heart disease before birth, improving understanding of its development.* ! -
  • Fetal cardiac intervention (FCI), including procedures like fetal aortic valvuloplasty (FAV), aims to reduce severe complications in newborns by addressing certain heart defects in utero.* ! -
  • The review covers the history, reasons for FAV, how to choose candidates, procedure details, results so far, and highlights the need for a multidisciplinary team to carry out these interventions.* !
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Background: Percutaneous transcatheter pulmonary valve replacement (TPVR) has good clinical and hemodynamic outcomes in treating dysfunctional bioprosthetic valves (BPV) in the pulmonary position. Valve-in-valve therapy can further decrease the inner diameter (ID), potentially resulting in patient-prosthesis mismatch in patients with smaller BPVs.

Methods And Results: To evaluate feasibility and outcomes of intentional BPV fracture to enlarge the pulmonary valve orifice with TPVR, 37 patients from 13 centers who underwent TPVR with intended BPV fracture were evaluated.

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Transcatheter stent implantation for SVC obstruction following OHT has been well described, particularly in pediatric patients. This study describes a large single-center pediatric heart transplant experience that investigates the risk factors for SVC stenosis requiring stent implantation and its associated outcomes. All pediatric OHTs between January 1, 2000, and December 12, 2016, were examined for risk factors.

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Balloon-expandable stents, implanted in infants and children with congenital heart disease (CHD), often require redilation to match somatic growth. Small diameter stents may eventually require longitudinal surgical transection to prevent iatrogenic vascular stenosis. Intentional transcatheter stent fracture (TSF) is an emerging alternative approach to stent transection, but little is known about the optimal stent substrate and best protocol to improve the likelihood of successful TSF.

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A 20-month-old boy with Williams syndrome had undergone multiple surgical and catheter-based interventions for resistant peripheral pulmonary arterial stenoses with eventual bilateral stent placement and conventional balloon angioplasty. He persistently developed suprasystemic right ventricular (RV) pressure. Angioplasty with a drug-coated balloon (DCB) was performed for in-stent restenosis and to remodel his distal pulmonary vessels bilaterally.

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Objective: Intravascular stents are now routinely used to treat young patients with vascular stenoses. Future stent redilations are often necessary to account for somatic growth. The purpose of this study was to compile a database of characteristics for stents commonly used in the treatment of congenital heart disease patients, and compare serial dilation to direct dilation to the maximal diameter.

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