Performance of Different Versions of Duke Criteria in Diagnosing Infective Endocarditis in Patients With Intracardiac Prosthetic Materials.

Background: Diagnosing infective endocarditis (IE) is a significant challenge. This study aimed to compare the diagnostic performance of the 2015 and 2023 European Society of Cardiology (ESC) and the 2023 International Society for Cardiovascular Infectious Diseases (ISCVID) Duke clinical criteria in a cohort of patients with suspected IE and intracardiac prosthetic material.

Methods: This retrospective study was conducted at 2 Swiss University Hospitals (2014-2024).

Evaluating Blood Culture Parameters to Identify Patients at Low Risk of Infective Endocarditis Among Those With Bacteremia by Gram-positive Cocci.

Background: Identifying patients at low risk for infective endocarditis (IE) among those with bacteremia by Gram-positive cocci is critical to optimize cardiac imaging use. The aim was to assess the diagnostic performance of blood culture parameters in identifying patients at low risk for IE.

Methods: Adult patients with bacteremia due to , streptococci, or at the Lausanne University Hospital were included.

Treatment and follow-up of vascular graft and endograft infection: Delphi consensus document.

Scope: Vascular graft or endograft infection (VGEI) is a severe complication requiring a multidisciplinary approach combining surgery and antimicrobial therapy. This study aimed to develop expert consensus on the management and follow-up of VGEI, with a focus on antimicrobial strategies.

Methods: A modified Delphi method was conducted to reach consensus on key aspects of VGEI care, including antimicrobial treatment, surgical management, and follow-up.

Should Microhematuria Be Incorporated into the 2023 Duke-International Society for Cardiovascular Infectious Diseases Minor Immunological Criteria?

: Microhematuria is common in patients with infective endocarditis (IE). The present study aims to assess whether the addition of microhematuria in the 2023 Duke-International Society for Cardiovascular Infectious Diseases (ISCVID) minor immunological criteria could enhance its diagnostic performance. : This retrospective study was conducted at the Lausanne University Hospital, Switzerland (2014-2024).

Evaluation of Different Versions of the Duke Criteria for the Diagnosis of Infective Endocarditis Among Patients With Enterococcal Bacteremia; a Multicenter Study.

Background: Enterococci are a common cause of infective endocarditis (IE). This study aimed to assess the diagnostic performance of the 2015 and 2023 Duke versions of the European Society of Cardiology (ESC) Duke criteria, as well as the 2023 Duke International Society of Cardiovascular Infectious Diseases (ISCVID) clinical criteria, for identifying IE among patients with enterococcal bacteremia.

Methods: We included adult retrospective patients with enterococcal bacteremia from 3 independent cohorts across 2 Swiss university hospitals between 2015 and 2024.

Update on prevention and antimicrobial prophylaxis of infective endocarditis.

The Swiss expert group published revised guidelines on the prevention and antibiotic prophylaxis against infective endocarditis in 2021. In this viewpoint article, the group reports on their experiences two years after implementing the new prevention concept, which included information flyers and antimicrobial prophylaxis cards. Challenges included communicating the concept and indications for antimicrobial prophylaxis to both high-risk patients and providers.

Predictors of mortality of enterococcal bacteraemia and the role of source control interventions; a retrospective cohort study.

Purpose: To identify predictors of mortality among patients with enterococcal bacteraemia.

Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included adult patients with enterococcal bacteraemia from 2014 to 2023.

Results: During the study period, 768 enterococcal bacteraemia episodes were included.

Factors associated with persistent bacteraemia among patients with suspected infective endocarditis.

Purpose: To ascertain the predictors of persistent bacteraemia among patients with suspected infective endocarditis (IE) and those with IE.

Methods: Retrospective study.

Setting: This study conducted at a Swiss university hospital (2015-2023) included adult patients with bacteraemia and suspected IE.

Validation of the Proposed Definition for Complicated Coagulase-negative Staphylococcal Bacteremia.

Background: A new definition for complicated coagulase-negative staphylococcal (CoNS) bacteremia was recently proposed. The aim of this study was to identify predictors of mortality in patients with CoNS bacteremia and evaluate the proposed definition of complicated bacteremia.

Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland (2015-2023) and included adult patients with CoNS bacteremia.

Full-root aortic valve replacement using Medtronic Freestyle bioroots for infective endocarditis.

Objectives: This study aims to explore the potential efficacy of the Freestyle Medtronic bioroot in the treatment of aortic endocarditis, based on our single-centre experience.

Methods: In this retrospective study conducted between 2015 and 2023, adult patients who underwent aortic root replacement with coronary arteries reimplantation using the modified Bentall technique with a Medtronic Freestyle bioroot in our centre for infective endocarditis were included.

Results: Thirty patients, with five deaths, no cases of relapse and two cases of reinfection, were included, and prosthetic valve endocarditis represented 73.

Comparison of the 2023 ISCVID and ESC Duke clinical criteria for the diagnosis of infective endocarditis among patients with positive blood cultures for new typical microorganisms.

Purpose: To evaluate the performance of the Duke clinical criteria of the European Society of Cardiology (ESC; 2015 and 2023 versions) and the 2023 International Society for Cardiovascular Infectious Diseases (ISCVID) in diagnosing infective endocarditis (IE) among patients with bacteraemia/candidaemia by pathogens introduced for the first time as typical microorganisms by ISCVID.

Methods: Retrospective study.

Setting: This study included adult patients with bacteraemia/candidaemia by such pathogens (coagulase negative staphylococci, Abiotrophia spp.

Role of the New Physical Examination Minor Criterion (New Heart Murmur) for the Diagnosis of Infective Endocarditis.

Among 3127 episodes of suspected infective endocarditis, the 2023 Duke-International Society for Cardiovascular Infectious Diseases clinical criteria showed an accuracy of 90% for infective endocarditis diagnosis. A new heart murmur was present in 690 (22%) episodes. Excluding imaging and surgical findings decreased the accuracy to 73%, while using the physical examination criterion slightly improved the accuracy to 78%.

Predictors of Persistent Fever Among Patients With Suspected Infective Endocarditis: Think Outside the box.

Background: Fever is common in infective endocarditis (IE), yet little is known about fever duration in such patients. We aim to identify predictors of persistent fever in patients with suspected IE.

Methods: This study was conducted at the Lausanne University Hospital, Switzerland, from January 2014 to June 2023.

Duration of antimicrobial treatment for uncomplicated streptococcal bacteraemia: Another example of shorter is better.

Objectives: Duration of treatment for uncomplicated streptococcal bacteraemia is unknown. The study aims to assess clinical outcomes of patients with uncomplicated streptococcal bacteraemia receiving a short course (5-10 days) of antimicrobial treatment compared to those receiving the traditional, longer duration (11-18 days).

Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included episodes of uncomplicated streptococcal bacteraemia among adult patients from 2015 to 2023.

Impact of multidisciplinary Endocarditis Team on management of infective endocarditis.

Infective Endocarditis (IE) is a complex, life-threatening disease. The aim of the present study was to evaluate the impact of the Endocarditis-Team on management of IE. This observational study conducted at a university hospital (2015‒22), included adult patients with IE.

Predictors of mortality of Pseudomonas aeruginosa bacteraemia and the role of infectious diseases consultation and source control; a retrospective cohort study.

Purpose: To determine predictors of mortality among patients with Pseudomonas aeruginosa bacteraemia.

Methods: Retrospective study.

Setting: This study conducted at the Lausanne University Hospital, Switzerland included adult patients with P.

Antibody and T-Cell Response to Bivalent Booster SARS-CoV-2 Vaccines in People With Compromised Immune Function: COVERALL-3 Study.

Background: Bivalent messenger RNA (mRNA) vaccines, designed to combat emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, incorporate ancestral strains and a new variant. Our study assessed the immune response in previously vaccinated individuals of the Swiss HIV Cohort Study (SHCS) and the Swiss Transplant Cohort Study (STCS) following bivalent mRNA vaccination.

Methods: Eligible SHCS and STCS participants received approved bivalent mRNA SARS-CoV-2 vaccines (mRNA-1273.

Evaluation of the HANDOC Score and the 2023 International Society of Cardiovascular Infectious Diseases and European Society of Cardiology Duke Clinical Criteria for the Diagnosis of Infective Endocarditis Among Patients With Streptococcal Bacteremia.

Background: Streptococci are a common cause of infective endocarditis (IE). We aimed to evaluate the performance of the HANDOC score to identify patients at high risk for IE and the Duke clinical criteria of the European Society of Cardiology (ESC; 2015 and 2023 versions) and the 2023 version from the International Society of Cardiovascular Infectious Diseases (ISCVID) in diagnosing IE among patients with streptococcal bacteremia.

Methods: This retrospective study included adult patients with streptococcal bacteremia hospitalized at Lausanne University Hospital.

Association of persistent positive blood cultures and infective endocarditis: A cohort study among patients with suspected infective endocarditis.

Objectives: To ascertain whether infective endocarditis (IE) was associated with persistent bacteraemia/candidaemia among patients with suspected IE.

Methods: This study included bacteraemic/candidaemic adult patients with echocardiography and follow-up blood cultures. Persistent bacteraemia/candidaemia was defined as continued positive blood cultures with the same microorganism for 48 h or more after antibiotic treatment initiation.

Predictors of Mortality of Streptococcal Bacteremia and the Role of Infectious Diseases Consultation: A Retrospective Cohort Study.

Background: Streptococcal bacteremia is associated with high mortality. Thia study aims to identify predictors of mortality among patients with streptococcal bacteremia.

Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland, and included episodes of streptococcal bacteremia among adult patients from 2015 to 2023.