Publications by authors named "Matteo Anselmino"

Atrial fibrillation (AF) is increasingly diagnosed early, close to its first occurrence due to: (i) increased public awareness with self-screening; (ii) health care initiatives including population screening and opportunistic case finding; and (iii) increased use and surveillance of implantable cardiac devices. At its onset, AF is often low burden, and cardiovascular co-morbidities may be absent or at an early stage. Thus, the management of recent-onset AF has become an issue of growing importance.

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: International guidelines differ on short-term (4-week) oral anticoagulation (OAC) indication after acute cardioversion for recent-onset atrial fibrillation (AF < 12-48 h) in low-risk patients (CHADS-VA = 0). While Canadian and Chinese guidelines recommend OAC for all, European, Australian and New Zealand, and American guidelines state that such treatment is optional due to the absence of high-quality evidence supporting its indication in this specific scenario. This study aimed to assess physicians' management of a simple clinical case at an international level, focusing on how they balance ischemic and bleeding risks in a setting lacking any strong evidence-based recommendations.

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Integrating Artificial Intelligence (AI) with electrocardiograms (ECG) represents a transformative shift in cardiovascular medicine, marking a modern renaissance of this traditional diagnostic technique. This article explores recent advancements in AI-enhanced ECG technologies, highlighting their potential to improve diagnostic accuracy, predict cardiovascular events, and enable personalized patient care. AI-driven ECG interpretation has demonstrated groundbreaking capabilities in the field of both structural and electrical heart diseases.

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Aims: Despite increasing prevalence, the general population lacks knowledge regarding diagnosis, implications, and management of cardiac arrhythmias (CA). This study aims to assess public perception of CA and identify knowledge gaps.

Methods And Results: The 36-item PULSE survey was disseminated via social media to the general population and conducted under the auspices of the European Heart Rhythm Association Scientific Initiatives Committee (EHRA SIC) with EHRA patient committee support.

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Backgrounds: After a decade since the introduction of leadless pacemaker (L-PM), its use is still limited. The aim of this survey is to evaluate how this technology is perceived by electrophysiologist members of a National scientific society in clinical practice.

Methods: A questionnaire with 22 questions was posted in the reserved area of the society website.

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Cardioneuroablation (CNA) is emerging as an appealing therapeutic option for patients with vasovagal reflex syncope. This review examines key aspects of CNA, including patient selection, procedural aspects and mid-term effects. We critically evaluate procedural results from recent studies and address ongoing challenges, such as the need for standardized procedural protocols and harmonized postprocedural data collection.

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Background: Catheter ablation of atrial fibrillation has been proven beneficial in patients with heart failure and reduced ejection fraction (HFrEF). On top of pulmonary vein isolation (PVI), additional ablation strategies such as empirical lines/posterior box/low voltage ablation (PVI+L/LVA) are often used. Whether PVI+L/LVA provides additional benefits in this population has never been systematically investigated.

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Background: Recent advancements in ultra-high-density mapping (UHDM) featuring automated functionalities have enhanced our understanding of micro-reentrant atrial tachycardias (mAT) circuits and the precise localization of the origin.

Purpose: To evaluate the diagnostic support provided by an automated UHDM algorithm in guiding the ablation of mATs.

Methods: Consecutive patients eligible for AT ablation in 22 Italian centers were prospectively enrolled.

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Brugada syndrome (BrS) is a genetic condition that increases the risk of life-threatening arrhythmias, which can result in sudden cardiac death (SCD). Implantable loop recorders (ILRs) have become a key tool in managing patients with unexplained syncope, and guidelines advise their use in individuals with recurrent, unexplained syncope or palpitations. However, the role of ILRs in inherited arrhythmic conditions like BrS remains a topic of debate.

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Atrial high-rate episodes (AHREs) and subclinical atrial fibrillation (AF) are frequently registered in asymptomatic patients with cardiac implantable electronic devices (CIEDs) and insertable cardiac monitors (ICMs). While an increased risk of thromboembolic events (e.g.

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Article Synopsis
  • Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), specifically semaglutide, show cardiovascular benefits and may reduce the incidence of atrial fibrillation (AF) in high-risk patients.
  • A meta-analysis of 10 randomized clinical trials involving 12,651 patients revealed a 42% reduction in the risk of AF with semaglutide compared to placebo during an average follow-up of 68 months.
  • The study found no significant differences in AF risk reduction based on the route of administration (oral or subcutaneous), as well as no influence from baseline characteristics like diabetes status or BMI.
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Background: The combination of highly localized impedance (LI) and contact force (CF) may improve tissue characterization and lesion prediction during radiofrequency (RF) pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF).

Objective: We report the outcomes of our acute and long-term clinical evaluation of CF-LI-guided PVI in consecutive AF ablation cases from an international multicenter clinical setting.

Methods: Three hundred twenty-four consecutive patients from 20 European centers undergoing RF catheter ablation with the Stablepointâ„¢ catheter were enrolled in the CHARISMA registry.

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Background: Cardiac resynchronization therapy (CRT) represents an effective heart failure treatment, associated with reduction in mortality and heart failure hospitalizations. This Italian survey aimed to address relevant CRT issues.

Methods: An online survey was administered to AIAC members.

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Article Synopsis
  • Atrial fibrillation (AF) is linked to an increased risk of vascular dementia and cognitive impairment due to changes in deep cerebral blood flow, with lenticulostriate arteries (LSAs) being particularly affected.
  • The study used computational fluid dynamics (CFD) and high-resolution MRI to analyze the LSA's shape and its influence on blood flow during AF, identifying key features like MCA size and bifurcation angles.
  • Findings suggest that LSAs with larger angles and smaller MCA sizes may be more susceptible to vascular damage caused by AF, highlighting the importance of LSA morphology in cerebral hemodynamics.
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  • Catheter ablation for atrial fibrillation (AF) is the most common procedure in electrophysiology, aiming to isolate pulmonary veins, but there is insufficient data on severe complications worldwide.
  • A study involved collecting and analyzing data from 23 centers with 33,879 procedures to determine the incidence and management of severe complications during AF ablation.
  • The study found that while severe complications like tamponade and stroke have a low incidence, factors like age, gender, and procedure duration play a role in their occurrence; most patients with complications were discharged after about 5 days.
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Background: Pulsed field ablation (PFA) and very high-power short-duration (vHPSD) radiofrequency ablation are the most recently introduced technologies for atrial fibrillation (AF) ablation. The procedural performance, safety, and effectiveness of PFA vs vHPSD are currently unknown.

Objective: The study aimed to compare PFA with vHPSD for the treatment of paroxysmal or persistent AF.

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The relationship between epicardial adipose tissue (EAT) and atrial fibrillation (AF) has gained interest in recent years. The previous literature on the topic presents great heterogeneity, focusing especially on computed tomography imaging. The aim of the present study is to determine whether an increased volume of left atrial (LA) EAT evaluated at routine pre-procedural cardiac magnetic resonance imaging (MRI) relates to AF recurrences after catheter ablation.

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Article Synopsis
  • * This study aimed to analyze how long R-R intervals during AF affect cerebral blood flow and oxygenation using near-infrared spectroscopy (NIRS) in patients undergoing electrical cardioversion.
  • * Findings showed that long R-R intervals significantly lowered diastolic blood pressure and cerebral blood volume, with subsequent decreases in oxygen levels; these changes were temporary and smoothed out over time, suggesting the brain's regulatory mechanisms are at work in response to these blood flow fluctuations.
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  • The study investigates the effectiveness and safety of continuous percutaneous stellate ganglion block (C-PSGB) compared to thoracic epidural anesthesia (TEA) for treating refractory ventricular arrhythmias in patients with advanced heart disease.
  • C-PSGB was performed on 26 patients, resulting in 59% experiencing complete suppression of arrhythmias and 94% showing overall clinical benefits, while TEA had higher side-effect-related discontinuation rates.
  • Overall, the findings suggest that C-PSGB is a promising and safer alternative for managing these heart conditions, especially for patients on anticoagulation therapy.
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Background: Diagnosis of pericarditis may be challenging because not all patients meet the conventional criteria. An overlooked diagnosis implies a longer course of symptoms and an increased risk of recurrences. C-reactive protein (CRP), widely used as an inflammation marker, has some limitations.

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Background: Artificial intelligence (AI) has shown promise in the early detection of various cardiac conditions from a standard 12-lead electrocardiogram (ECG). However, the ability of AI to identify abnormalities from single-lead recordings across a range of pathological conditions remains to be systematically investigated. This study aims to assess the performance of a convolutional neural network (CNN) using a single-lead (D1) rather than a standard 12-lead setup for accurate identification of ECG abnormalities.

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Article Synopsis
  • Recognizing the cause of cerebral ischemic events is crucial for effective treatment and prevention, yet there are no standard MRI criteria to identify an embolic etiology.
  • This study aims to analyze the MRI characteristics of ischemic brain lesions that occur after transcatheter ablation of atrial fibrillation (AF) by systematically reviewing various studies.
  • Results show that 17.2% of patients developed ischemic lesions post-ablation, primarily small cortical lesions under 10 mm, mostly found in the middle cerebral artery region, with a very low rate of symptomatic issues.
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