Publications by authors named "Mathieu Pavoine"
Background: This study focuses on modeling a population-based input function (PBIF) in dynamic ⁶⁸Ga-DOTATOC PET/CT exams, with the aim of developing clinically adoptable protocols. The PBIF is derived from an image-derived input function (IDIF), ensuring a non-invasive and standardized approach to tracer kinetic modeling.
Methods: Patients with well-differentiated neuroendocrine tumors were included from the GAPETNET clinical trial (n = 37), divided into a PBIF modeling group (n = 20) and an independent validation group (n = 17).
Background: A current limitation to the use of lung PET/CT is the absence of a tool that reliably and reproducibly quantifies the intensity of tracer uptake. We aim to develop a quantitative approach for lung perfusion PET/CT imaging. Sixty patients who underwent [68Ga]Ga-MAA PET/CT scans before (M0) and 3 months (M3) after completion of radiotherapy were analyzed.
View Article and Find Full Text PDFBackground: The aim was to investigate the feasibility of a shortened dynamic whole-body (dWB) FDG-PET/CT protocol and Patlak imaging using a population-based input function (PBIF), instead of an image-derived input function (IDIF) across the 60-min post-injection period, and study its effect on the FDG influx rate (Ki) quantification in patients with metastatic melanoma (MM) undergoing immunotherapy.
Methods: Thirty-seven patients were enrolled, including a PBIF modeling group (n = 17) and an independent validation cohort (n = 20) of MM from the ongoing prospective IMMUNOPET2 trial. All dWB-PET data were acquired on Vision 600 PET/CT systems.
Article Synopsis
- - The study aimed to validate a population-based input function (PBIF) model for dynamic whole-body PET scans that eliminates the need for lengthy scanning times after injection.
- - Involving 37 patients with neuroendocrine tumors, the PBIF model was developed using data from previous scans and successfully tested on 17 independent cases, showing accurate area under the curve (AUC) ratios and minimal differences in physiological uptake measurements.
- - Results indicated that using the PBIF can reduce whole-body DOTATOC-PET/CT acquisition times by at least 20 minutes while maintaining accuracy in measuring tumor and organ uptake.