Publications by authors named "Matheus G Barcelos"
Background: To develop an effective vaccine against Plasmodium vivax, the most widely dispersed human malaria parasite, it is critical to understand how coinfections with other pathogens could impact malaria-specific immune response. A recent conceptual study proposed that Epstein-Barr virus (EBV), a highly prevalent human herpesvirus that establishes lifelong persistent infection, may influence P. vivax antibody responses.
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- Superinfection inhibition occurs when certain viruses prevent additional viruses from entering infected host cells, ensuring the genetic dominance of the first virus.
- Research has explored this phenomenon in giant amoeba-infecting viruses, specifically mimivirus and moumouvirus, which have shown the ability to inhibit new infections, while megavirus does not.
- The study highlights that mimivirus and moumouvirus disrupt amoebic phagocytosis, altering host cell behavior, whereas megavirus allows continued entry of new virions, indicating significant differences in viral-host interactions despite their evolutionary similarities.
Article Synopsis
- The discovery of mimivirus in 2003 sparked global interest in exploring giant viruses, yet their diversity and distribution remain largely unknown.
- A study conducted from 2012 to 2022 focused on isolating amoebal viruses from various Brazilian biomes using Acanthamoeba castellanii, processing 881 samples.
- The research identified 67 amoebal viruses across all sample types and biomes, including several significant types like mimiviruses and marseilleviruses, showcasing the biodiversity of giant viruses in Brazil.
Surface fibrils on the particles of nucleocytoviruses: A review.
Exp Biol Med (Maywood)
November 2023
Article Synopsis
- The capsid of a virus plays a crucial role in its life cycle, mainly by protecting its genetic material and facilitating interaction with host cells to promote infection.
- Research has notably focused on giant viruses (GVs) that infect protists, which have unique capsid structures with bacterial-like dimensions and numerous proteins.
- This review highlights the intriguing surface fibrils found on mimivirus capsids, discussing their characteristics, functions, and variations across different nucleocytoviruses.
Background: The simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-established that eBL is not related to other human malaria parasites, the impact of EBV infection on the generation of human malaria immunity remains largely unexplored.
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