Regulatory KIRCD8 T cells are elevated during human pregnancy.

During pregnancy, immune responses must balance protection from infections with tolerance of the semiallogeneic fetus. However, the mechanisms regulating maternal-fetal tolerance remain poorly understood. Recently, we identified CD8 T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) as a regulatory subset important for suppressing self-reactivity in human autoimmune and infectious diseases.

Immune impacts of fire smoke exposure.

Exposure to fire smoke has become a global health concern and is associated with increased morbidity and mortality. There is a lack of understanding of the specific immune mechanisms involved in smoke exposure, with preventive and targeted interventions needed. After exposure to fire smoke, which includes PM, toxic metals and perfluoroalkyl and polyfluoroalkyl substances, epidemiology-based studies have demonstrated increases in respiratory (for example, asthma exacerbation), cardiac (for example, myocardial infarction, arrhythmias), neurological (for example, stroke) and pregnancy-related (for example, low birthweight, premature birth) outcomes.

Fine Particulate Matter From 2020 California Wildfires and Mental Health-Related Emergency Department Visits.

Importance: A growing body of research suggests that exposure to fine particulate matter (PM2.5; particle size 2.5 microns or smaller) may be associated with mental health outcomes.

Exposomics: a review of methodologies, applications, and future directions in molecular medicine.

The exposome is the measure of all the exposures of an individual in a lifetime and how those exposures relate to health. Exposomics is the emerging field of research to measure and study the totality of the exposome. Exposomics can assist with molecular medicine by furthering our understanding of how the exposome influences cellular and molecular processes such as gene expression, epigenetic modifications, metabolic pathways, and immune responses.

The Effect of Wildfires on Asthma and Allergies.

Climate change is a major driver of the frequency and severity of wildfires caused by extended periods of drought and hotter, drier weather superimposed on the legacy of fire suppression in the Mountain West of the United States. In recent years, increased wildfire smoke has negated the improvements in air quality made by clean energy transitions. Wildfire smoke is a complex mixture of gases and solids, a chief constituent of which is fine particulate matter (PM).

Spatial analysis and land use regression of VOCs and NO(2) from school-based urban air monitoring in Detroit/Dearborn, USA.

Passive ambient air sampling for nitrogen dioxide (NO(2)) and volatile organic compounds (VOCs) was conducted at 25 school and two compliance sites in Detroit and Dearborn, Michigan, USA during the summer of 2005. Geographic Information System (GIS) data were calculated at each of 116 schools. The 25 selected schools were monitored to assess and model intra-urban gradients of air pollutants to evaluate impact of traffic and urban emissions on pollutant levels.

Profiles of trace elements in toenails of Arab-Americans in the Detroit area, Michigan.

Exposure to environmental contaminants is complicated by factors related to socioeconomic status, diet, and other culturally conditioned risk behaviors. Determination of a trace element profile in toenails can be used as a tool in biomonitoring the exposure history or assessing the deficiency of a particular element in a study population, which can lead to a better understanding of environmental and disease risks. Toenail clippings from 259 Arab Americans (163 adults, 96 children) residing in a highly industrialized area were analyzed for Al, V, Cr, Mn, Co, Ni, Cu, As, Se, Mo, Cd, Ba, Tl, and Pb using an inductively coupled plasma-mass spectrometer.