Oxygen deficient MoO nanoparticles as peroxidase substitutes, their substrate-nanozyme interactions and real time validation in human serum sample.

Oxygen deficient molybdenum oxide nanosheet (Od-MO Nshs) was synthesised by hydrothermal method and its peroxidase-like activity was established with 3,3',5,5'-Tetramethylbenzidine-(TMB) and o-phenylenediamine dihydrochloride-(OPD) as a co-substrate in presence of Hydrogen peroxide (HO) and catalytic parameters were compared with horseradish peroxidase-(HRP) enzyme. Optimization was carried out for physical and chemical parameters. Synthesised nanoparticles-(NPs) were characterized for size, shape, composition oxidation state etc.

Role of Stem Cells on Neuropathic Pain Recovery in Patients with Spinal Cord Injury: A Systematic Review.

Stem cell transplantation has shown promise in providing pain relief for patients with chronic SCI by releasing transforming growth factor β (TGF-β). This systematic review aims to evaluate stem cell's effectiveness in recovering neuropathic pain in patients with spinal cord injury. The study followed the PRISMA guidelines and included patients with chronic spinal cord injury who received stem cells compared with a control group.

Prediction of metastatic potential of heterogeneous pancreatic ductal adenocarcinoma through gradient-based algorithms.

Background: Pancreatic ductal adenocarcinoma carries a dismal prognosis, with five-year survival below 10 % due to late presentation, aggressive nature, and profound intratumor heterogeneity. Existing prognostic models fail to account for the dynamic interplay between subclonal evolution and the tumor microenvironment, limiting their clinical utility for risk stratification and therapy guidance.

Methods: An in silico, multiscale framework was developed, combining an agent-based model of subclone proliferation, migration, quiescence, and apoptosis with continuum reaction-diffusion equations for oxygen, nutrients, extracellular matrix, and chemoattractants.

Evaluation of peroxidase mimicking behaviour of VO nanozymes with various morphologies and its application as glucose sensor via cascade mechanism in human serum samples.

A simple spectrophotometric method is presented for quantifying glucose and HO using p-aminophenol sulfate-(PAP) & N-(1-Naphthyl) ethylenediamine dihydrochloride-(NEDA) as novel chromogenic reagents with different morphological VO nanoparticles (NPs) as peroxidase mimicking nanozyme. For glucose, the method was linear in the range of 0.0289 and 0.

Evaluation of the efficacy of tongue swab and saliva as samples for testing COVID-19 infection in symptomatic cases in comparison with nasopharyngeal swab.

COVID-19 caused by SARS CoV-2 continues to be a major health concern globally. Methods for detection of the disease are necessary for public health efforts to monitor the spread of this disease as well as for detecting the emergence of new variants. Collection of Nasopharyngeal swab (NPS), the gold standard sample for the detection of COVID-19 infection by RT-qPCR is invasive and requires the expertise of a trained medical provider.

Ginger potency on the prevention and treatment of breast cancer.

Background: Cancer is a type of disease caused by the uncontrolled growth of abnormal cells that can destroy body tissues. The use of traditional medicine naturally uses plants from ginger with the maceration method. The ginger plant is a herbaceous flowering plant with the Zingiberaceacea group.

Controlling the growth rate of cancer cell.

To control the rate of growth of the cancer cell is the objective of this paper. In cancer, the rate of the growth of the cancer cell is indefinite. This paper proposes a method to transform into definite rate of growth of the cancer cell from indefinite.

Massive Lymphedema Necessitating Disarticulation of Shoulder Joint Following Treatment for Carcinoma Breast.

We report a case of massive upper-limb edema necessitating disarticulation, in a cancer survivor who tended to ignore instructions regarding preventive exercises since 2002 after completion of her treatment for breast cancer. However, she was in a family situation where she was constrained to physically involve in daily chores. Consequently, she presented 14 years later with a lymphedematous arm which weighed over 31 kg, necessitating disarticulation.

Spectrophotometric determination of some chemotherapeutic agents using acetyl acetone.

Acetyl acetone is introduced as a new coupling agent for the spectrophotometric determination of some chemotherapeutic agents, such as metoclopramide, dapsone, p-aminobenzoic acid, and cisapride in both pure and dosage forms. The method is based on the diazo-coupling reaction of these chemotherapeutic agents with a new coupling agent, acetyl acetone, in an alkaline medium. The optimum reaction conditions and other analytical parameters are evaluated.

Spectrophotometric methods for the determination of ritodrine hydrochloride and its application to pharmaceutical preparations.

Two simple and sensitive spectrophotometric methods are described for the determination of ritodrine hydrochloride (RTH) in both pure and dosage forms. The methods are based on the interaction of diazotised p-nitroaniline (DPNA) and sulphanilic acid (DSNA) with RTH in an alkaline medium. The resulting azo dyes are measured at 480 nm (for the DPNA method) and at 440 nm (for the DSNA method) and are stable for more than 1 h.

Fungal mediated decolorization of media containing procion dyes.

An isolated fungus, Aspergillus foetidus was found to effectively decolorize media containing azo reactive dyes, namely Procion dyes, under aerobic conditions. The extent of colour removal was 90% within 48 h of growth of the fungus. The entire colour was found to be strongly bioadsorbed to the rapidly settling spherical fungal biomass pellets.

A spectrophotometric method for the determination of metoclopramide HCl and dapsone.

A rapid, sensitive and selective spectrophotometric method has been developed for the quantitative determination of metoclopramide hydrochloride (MCP) and dapsone (DAP) in both pure and dosage forms. The method is based on the diazo coupling reaction of the drugs with a new coupling agent, dibenzoyl methane in an alkaline medium. The resulting coloured azo dyes exhibit maximum absorption at 440 nm for MCP and at 470 nm for DAP with a molar absorptivity of 2.

Spectrophotometric determination of ritodrine and isoxsuprine hydrochlorides using 4-aminoantipyrine.

A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent. The resulting products are measured at 510 nm for both drugs, with molar absorptivities of 0.

Uptake of reactive textile dyes by Aspergillus foetidus.

An isolated fungus, Aspergillus foetidus was found to effectively decolorize media containing azo reactive dyes namely, Drimarene dyes. The extent of color removal was greater than 95% within 48 h of growth of the fungus. The entire color was found to be strongly bioadsorbed to the rapidly settling fungal biomass pellets without undergoing significant biotransformation.

Spectrophotometric determination of some antidepressant drugs using 3-methylbenzothiazolin-2-one hydrazone.

A sensitive spectrophotometric method for the determination of amitriptyline hydrochloride, nortriptyline hydrochloride and doxepin hydrochloride in pure and dosage forms, is described. The method is based on the oxidative coupling of the drugs with 3-methylbenzothiazolin-2-one hydrazone in the presence of iron(III) chloride in 1 M hydrochloric acid. The commonly encountered excipients and additives do not interfere with the determinations.