A reversible eugenol derived colorimetric and fluorescence "turn-off" probe for Fe and Pb ions detection.

A simple and robust colorimetric and fluorescent eugenol-based chemical sensor, namely, (E)-N'-(5-allyl-2-hydroxy-3-methoxybenzylidene)-2-hydroxybenzohydrazide (EABH) was synthesized and characterized using spectroscopic techniques such as, NMR (H and C) and mass spectra. The chemosensor shows dual behavior for the colorimetric detection of Fe and fluorometric detection of Pb ions with high sensitivity and selectivity towards both the ions. The EABH detects Fe by "naked eye" color change from lime yellow to brown and displayed fluorescence "Turn-off" response to Pb ion.

LC-MS/MS characterization of pirtobrutinib impurities and product degradation: stability studies.

This study examined the fragmentation, degradation pathways and DPs of pirtobrutinib, which have not been previously reported in the literature. The main goal of the current work is to develop, validate, and characterize forced degradation products using LC-MS/MS. An isocratic HPLC methodology was developed for the quantitative measurement of pirtobrutinib at a of 219 nm.

Azaneylylidene-based tetradentate Schiff base as a new "ON-OFF" fluorescent probe for the detection of Cu(II) ion: Synthesis, characterization and real sample analysis.

Herein we describe the synthesis of Cu sensor, 2,2'-((1E,1'E)-((4-chloro-1,2-phenylene)bis(azaneylylidene))bis(methane-ylylidene))bis(4-bromophenol) (CPMB) and characterization using various spectral and analytical techniques. CPMB exhibited high selectivity towards Cu ions via fluorescence quenching mechanism, which combined the character of high selectivity towards Cu assay even in the presence of other common metal ions such as Cu, Al, Co, Ni, Mn, Zn Pb Cd, Fe, Hg, Mg and Fe (30 μM) ethanol-water (1:9 v/v) system. Upon the addition of the solution of Cu ions to CPMB, the complexation of Cu with CPMB leads to the immediate formation of light green color, indicating that CPMB can act as simple colorimetric sensor, particularly for Cu in the presence of most interfering metal ions in ethanol-water medium.

Novel Benzimidazole Derived Imine Ligand and Its Co(III) and Cu(II) Complexes as Anticancer Agents: Chemical Synthesis, DFT Studies, In Vitro and In Vivo Biological Investigations.

The emerging interest in the field of coordination chemistry and their biological applications has created a novel impact in the field of chemical biology. With this motivation, in this work we have synthesized a novel benzimidazole derived imine ligand, 2-((E)-((1H-benzo[d]-2-yl)methylimino)methyl)-4-fluorophenol () and its Co(III) and Cu(II) complexes. The metal complexes (-) were synthesized in 2:1 (: metal ion) and 1:1:1 (: metal ion: 1,10-phen) ratios.

Click synthesis of 1,2,3-triazole based imidazoles: Antitubercular evaluation, molecular docking and HSA binding studies.

Using Cu(I)-catalyzed cycloaddition of alkyne and azide reaction (CuAAC), a series of novel 1,2,3-triazole based imidazole derivatives (3a-e) have been synthesized. The synthesized molecules were characterized by spectroscopic techniques such as H NMR, C NMR, mass and elemental analysis. Antitubercular activity (anti-TB) against Mycobacterium tuberculosis H37Rv (Mtb) and cytotoxic activity against the mammalian Vero cell line was screened for the synthesized compounds.