The development of sustainable materials for green energy storage systems has accelerated due to the growing demand for energy worldwide and environmental concerns. Because of their large surface area, electrical conductivity, and adjustable structure, mesoporous graphitic carbon-based materials show the most promise for electrochemical hydrogen storage (EHS). The electrochemical performance of these materials is further improved by integrating them with transition metal oxides.
View Article and Find Full Text PDFJ Indian Prosthodont Soc
January 2025
Introduction: Accurate implant impressions are crucial for successful prosthetic rehabilitation. Digital impressions using intraoral scanners (IOS) have emerged as an alternative to conventional techniques. Various factors influence the accuracy of digital implant impressions, including scan body design, scanning protocol, and splinting techniques.
View Article and Find Full Text PDFUnlabelled: The Toll pathway plays a pivotal role in innate immune responses against pathogens. The evolutionarily conserved pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), play a crucial role in recognition of pathogen-associated molecular patterns (PAMPs). The genome encodes nine Toll receptors that are orthologous to mammalian TLRs.
View Article and Find Full Text PDFCyclobutane pyrimidine dimers (CPDs) are formed in DNA following exposure to ultraviolet (UV) light and are mutagenic unless repaired by nucleotide excision repair (NER). It is known that CPD repair rates vary in different genome regions owing to transcription-coupled NER and differences in chromatin accessibility; however, the impact of regional chromatin organization on CPD formation remains unclear. Furthermore, nucleosomes are known to modulate UV damage and repair activity, but how these damage and repair patterns are affected by the overarching chromatin domains in which these nucleosomes are located is not understood.
View Article and Find Full Text PDFFront Cell Infect Microbiol
December 2024
Arthropod-borne viruses or arboviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV) pose significant threats to public health. It is imperative to develop novel methods to control these mosquito-borne viral infections. We previously showed that insulin/insulin-like growth factor-1 signaling (IIS)-dependent activation of ERK and JAK-STAT signaling has significant antiviral activity in insects and human cells.
View Article and Find Full Text PDFUnlabelled: The Toll pathway plays a pivotal role in innate immune responses against pathogens. The evolutionary conserved pathogen recognition receptors (PRRs), including Toll like receptors (TLRs), play a crucial role in recognition of pathogen associated molecular patterns (PAMPs). The genome encodes nine Toll receptors that are orthologous to mammalian TLRs.
View Article and Find Full Text PDFAim: To evaluate and compare the effect of impregnated retraction cord vs Laser on gingival attachment level and pain perception following retraction for subgingival margins.
Settings And Design: Many methods for achieving and measuring the amount of gingival retraction in fixed prosthodontic work have been advocated. Though the gingival attachment level is crucial in Periodontology, the literature available regarding the effect of these retraction methods on the same is scarce.
STING (STimulator of Interferon Genes) is a cytosolic sensor for cyclic dinucleotides (CDNs) and initiates an innate immune response upon binding to CDNs. Coxiella burnetii is a Gram-negative obligate intracellular bacterium and the causative agent of the zoonotic disease Q fever. The ability of C.
View Article and Find Full Text PDFContext: Obstructive sleep apnoea is less known and lesser practised in dentistry. Dentists often struggle to educate, diagnose or offer treatment to the patient. Hence, the disorder of the patient and the opportunity for the dentist both go unnoticed.
View Article and Find Full Text PDFSoft pneumatic actuators have been explored for endoscopic applications, but challenges in fabricating complex geometry with desirable dimensions and compliance remain. The addition of an endoscopic camera or tool channel is generally not possible without significant change in the diameter of the actuator. Radial expansion and ballooning of actuator walls during bending is undesirable for endoscopic applications.
View Article and Find Full Text PDFMalaria is one of the major global health concerns still prevailing in this 21st century. Even the effect of artemisinin combination therapies (ACT) have declined and causing more mortality across the globe. Therefore, it is important to understand the basic biology of malaria parasite in order to find novel drug targets.
View Article and Find Full Text PDFPurpose: To evaluate and compare the wear of natural enamel against a metal-ceramic and a monolithic zirconia crown, with the null hypothesis that there is no difference in the wear of enamel between antagonist metal-ceramic and monolithic zirconia crowns.
Materials And Methods: In 30 subjects (irrespective of sex and within the age range of 18 to 40 years), two bilaterally opposing molars (maxillary/mandibular) were prepared to receive monolithic zirconia or metal-ceramic crowns with feldspathic porcelain veneer. A polyvinyl siloxane impression of the opposing arch was taken at the time of cementation and 1 year after cementation.
Fabrication of soft pneumatic bending actuators typically involves multiple steps to accommodate the formation of complex internal geometry and the alignment and bonding between soft and inextensible materials. The complexity of these processes intensifies when applied to multi-chamber and small-scale (~10 mm diameter) designs, resulting in poor repeatability. Designs regularly rely on combining multiple prefabricated single chamber actuators or are limited to simple (fixed cross-section) internal chamber geometry, which can result in excessive ballooning and reduced bending efficiency, compelling the addition of constraining materials.
View Article and Find Full Text PDFMalaria is a major infectious disease and is responsible for millions of infections every year. As drug resistance strains of species are emerging, there is an urgent need to understand the parasite biology and identify new drug targets. Helicases are very important enzymes that participate in various nucleic acid metabolic processes.
View Article and Find Full Text PDFFEBS Open Bio
November 2019
Malaria, a disease caused by infection with parasites of the genus Plasmodium, causes millions of deaths worldwide annually. Of the five Plasmodium species that can infect humans, Plasmodium falciparum causes the most serious parasitic infection. The emergence of drug resistance and the ineffectiveness of old therapeutic regimes against malaria mean there is an urgent need to better understand the basic biology of the malaria parasite.
View Article and Find Full Text PDFHuman malaria infection is a major challenge across the globe and is responsible for millions of deaths annually. Rapidly emerging drug resistant strains against the new class of anti-malarial drugs are major threat to control the disease burden worldwide. Helicases are present in every organism and have important role in various nucleic acid metabolic processes.
View Article and Find Full Text PDFInt J Comput Assist Radiol Surg
February 2019
Purpose: In transoral laser microsurgery (TLM), the close curved cylindrical structure of the laryngeal region offers functional challenges to surgeons who operate on its malignancies with rigid, single degree-of-freedom (DOF) forceps. These challenges include surgeon hand tremors, poor reachability, poor tissue surface perception, and reduced ergonomy in design. The integrated robotic microsurgical forceps presented here is capable of addressing the above challenges through tele-operated tissue manipulation in TLM.
View Article and Find Full Text PDFJ Inequal Appl
September 2018
We construct wavelets and derive a density condition of MRA in a higher-dimensional Sobolev space. We give necessary and sufficient conditions for orthonormality of wavelets in . We construct nonseparable orthonormal wavelets in a higher-dimensional Sobolev space by using multivariate box spline.
View Article and Find Full Text PDFPlasmodium falciparum is responsible for most dangerous and prevalent form of malaria. The emergence of multi drug resistant parasite hindered the prevention of malaria burden worldwide. Helicases are omnipresent enzymes, which play important role in nucleic acid metabolism and can be used as potential targets for development of novel therapeutics.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
August 2016
Transoral Laser Microsurgeries (TLM) demand a great level of control and precision in intraoperative tissue manipulation. The optimal eradication of the diseased tissue is possible only with coordinated control of the laser aiming for incision and the microsurgical tools for orienting and stretching the tissue. However, the traditional microsurgical tools are long, single purpose, one degree-of-freedom (DOF), rigid tools with small range of motion and a normal grasping handle inducing non-ergonomic usage.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
August 2016
In this paper, a novel, motorized, multi-degrees-of-freedom (DoF), microsurgical forceps tool is presented, which is based on a master-slave teleoperation architecture. The slave device is a 7-DoF manipulator with: (i) 6-DoF positioning and orientation, (ii) 1 open/close gripper DoF; and (iii) an integrated force/torque sensor for tissue grip-force measurement. The master device is a 7-DoF haptic interface which teleoperates the slave device, and provides haptic feedback in its gripper interface.
View Article and Find Full Text PDFFront Microbiol
February 2017
Malaria a major parasitic infection globally particularly in tropical and sub-tropical regions of the world is responsible for about 198 million cases and estimated deaths due to this disease are about 0.6 million. The emergence of drug resistance in the malaria parasite is alarming and it is necessary to understand its underlying cause and molecular mechanisms.
View Article and Find Full Text PDFMalaria caused by Plasmodium falciparum is the major disease burden all over the world. Recently, the situation has deteriorated because the malarial parasites are becoming progressively more resistant to numerous commonly used antimalarial drugs. Thus, there is a critical requirement to find other means to restrict and eliminate malaria.
View Article and Find Full Text PDF