Unrecognized chronic myeloid leukemia manifesting as hemorrhagic complications in proliferative diabetic retinopathy: A case report.

PurposeTo report a case of proliferative diabetic retinopathy (DR) complicated by concomitant undiagnosed chronic myeloid leukemia (CML).MethodsA known diabetic presented with minimal vitreous hemorrhage in left eye, along with Roth's spots and retinal hemorrhages in both eyes. Fundus fluorescein angiography revealed Proliferative DR with mid peripheral capillary non perfusion and neovascularization.

Pediatric retinal detachments in eyes with extreme high myopia: Presenting features and final outcomes.

Extreme high myopia is associated with structural changes to the eye. The elongation of the eye, with associated choroidal thinning and macular atrophy, makes these eyes more susceptible to complex retinal detachments (RD). In this case series, we present the course of four pediatric cases with RD.

Geographical differences in ophthalmic trauma outcomes and risk factors: the International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES).

Objectives: Characterise the international variation in ophthalmic trauma and determine risk factors associated with visual and anatomical outcomes for low-, middle- and high-income countries.

Subjects/methods: Observational multi-centre cohort study using data from the International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES) from April 2014 to August 2023. Data on acute presentations of ophthalmic injury including open/closed globe injury, and/or Adnexal/orbital involvement, and/or intraocular/ intraorbital foreign body were collected and Ocular Trauma Score (OTS) was calculated.

miRNAs, piRNAs, and lncRNAs: A triad of non-coding RNAs regulating the neurovascular unit in diabetic retinopathy and their therapeutic potentials.

Diabetic Retinopathy (DR), a leading complication of diabetes mellitus, has long been considered as a microvascular disease of the retina. However, recent evidence suggests that DR is a neurovascular disease, characterized by the degeneration of retinal neural tissue and microvascular abnormalities encompassing ischemia, neovascularization, and blood-retinal barrier breakdown, ultimately leading to blindness. The intricate relationship between the retina and vascular cells constitutes a neurovascular unit, a multi-cellular framework of retinal neurons, glial cells, immune cells, and vascular cells, which facilitates neurovascular coupling, linking neuronal activity to blood flow.

Systemic Biomarkers Predictive of Anatomical and Functional Outcomes of Macular Edema Secondary to Retinal Vein Occlusion Following a Single Injection of Intravitreal Bevacizumab.

Introduction: Macular edema (ME) secondary to retinal vein occlusion (RVO) is a leading cause for visual impairment.

Objective: To identify the systemic biomarkers that influence the anatomical and functional outcomes of a single injection of intravitreal bevacizumab (IVB) for RVO related macular edema ME.

Methodology: A prospective interventional study was conducted on patients with treatment naïve RVO induced ME, from November 2019 to April 2021 after ethical approval.

Closure rate and recovery of subfoveal microstructures following conventional internal limiting membrane peeling versus per fluoro octane-assisted inverted flap for large macular holes - A randomized controlled trial (InFlap Study).

Purpose: To analyze the outcomes following conventional internal limiting membrane (ILM) peeling versus perfluoro octane-assisted inverted flap technique for large macular holes (MH).

Methods: A consecutive 99 eyes of 99 patients were enrolled {45 - conventional group and 54 - inverted flap (InFlap) group}. The primary outcome was a difference in closure rate.

Aqueous misdirection syndrome post silicone oil removal in a vitrectomized eye - a case report.

Puropse: Aqueous misdirection syndrome (AMS) is an aggressive post-operative glaucoma unresponsive to conventional measures with grave outcomes. In this report, we describe a rare case of AMS following silicon oil removal in a vitrectomized eye.

Methods: A diabetic patient with tractional retinal detachment underwent pars plana vitrectomy with silicon oil injection.

Incidence of post vitrectomy endophthalmitis in India - A multicentric study by VRSI study Group.

Introduction: The incidence of post vitrectomy endophthalmitis (PVE) is reported to be between 0.02 and 0.84%.

Towards a Device Agnostic AI for Diabetic Retinopathy Screening: An External Validation Study.

Purpose: To evaluate the performance of a validated Artificial Intelligence (AI) algorithm developed for a smartphone-based camera on images captured using a standard desktop fundus camera to screen for diabetic retinopathy (DR).

Participants: Subjects with established diabetes mellitus.

Methods: Images captured on a desktop fundus camera (Topcon TRC-50DX, Japan) for a previous study with 135 consecutive patients (233 eyes) with established diabetes mellitus, with or without DR were analysed by the AI algorithm.

Morphological outcome and indication for laser following intravitreal bevacizumab monotherapy for posterior retinopathy of prematurity.

The purpose of this study is to determine the natural course of retinal vascular development and recurrence requiring laser in eyes receiving intravitreal bevacizumab (IVB) for posterior retinopathy of prematurity (ROP). Data of babies receiving IVB for posterior ROP was retrospectively analyzed. Birth weight, gestational age (GA) and post-menstrual age (PMA) at injection, need for laser, retinal maturation, and their timing were recorded.

Suprachoroidal hemorrhage following sutureless scleral-fixated intraocular lens - A case series.

Suprachoroidal hemorrhage (SH) is a rare complication of scleral-fixated intraocular lens (SFIOL). In this series, we report three cases of sutureless SFIOL who developed SH postoperatively. Details of surgery, treatment, and outcome were analyzed.

A Delphi method based consensus statement for surgical management of proliferative diabetic retinopathy in India.

Purpose: To derive consensus statements for surgical management of proliferative diabetic retinopathy (PDR) for vitreoretinal (VR) surgeons.

Methods: Thirteen prolific VR surgeons representing all regions of India were invited to participate in a 42-point questionnaire based on the Delphi methodology describing various surgical scenarios commonly encountered in PDR. Consensus was derived using predefined robust analytics.

Hyperreflective foci as biomarkers for inflammation in diabetic macular edema: Retrospective analysis of treatment naïve eyes from south India.

Purpose: The aim of this study was to analyze the factors associated with hyperreflective foci (HRF) in diabetic macular edema (DME) in treatment naïve eyes.

Methods: This retrospective observational study included 131 eyes of 91 treatment naïve patients with DME. Details of ophthalmological examination with duration of vision loss and systemic parameters were noted.

Profile of patients receiving intravitreal anti-vascular endothelial growth factor injections during COVID-19-related lockdown.

Purpose: The aim of this study was to analyze the impact on vision due to delay in presentation of patients requiring intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections, consequent to COVID-19-related travel restrictions.

Methods: Data were collected retrospectively of patients who received anti-VEGF injections during four months of the COVID-19 pandemic. Visual acuities, indication for treatment were noted along with basic demographic characteristics.

Clinical profile and outcomes of rhegmatogenous retinal detachment related to trauma in pediatric population.

Objective: To analyze the outcomes of trauma-related rhegmatogenous retinal detachment (RD) in pediatric population.

Design: Retrospective observational series.

Participants: All patients under 18 years of age who underwent surgery for RD following trauma from 2010 to 2018.

Outcomes of sutureless and sutured scleral fixated intraocular lens in paediatric population.

Purpose: To analyse the outcomes of sutureless and sutured scleral fixated intraocular lenses (SFIOL) in paediatric population.

Setting: Vitreoretina department of a tertiary eye care institute in Southern India.

Design: Retrospective case series.