Factorial design, formulation, in vitro and in vivo evaluation of a multi-layer tablet containing ticagrelor and aspirin, for dual antiplatelet therapy.

Dual antiplatelet therapy regimen is used for the management of acute coronary syndrome. To investigate the potential for combining ticagrelor and aspirin into a single-dose alternative for dual antiplatelet therapy, a factorial design (3) was applied to the formulation of a multi-layer tablet containing both drugs, each in a separate layer. The design focused on three levels, of two categorical independent factors: the type of disintegrant used in ticagrelor layer and the type used in aspirin layer.

Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits.

Objective: The purpose of this study was to prepare proniosomal vesicles of Telmisartan (TEL) to be compressed into tablets which will be further evaluated in vitro and in vivo.

Materials And Methods: An experimental design was adopted using surfactants of different HLB values (span 40-brij 35), different cholesterol ratios (20-50%) and different phospholipid types (egg yolk-soyabean). Different responses were measured followed by tablet manufacturing.