Comprehensive Review of Isoflavones and Lignans in the Prophylaxis and Treatment of Breast Cancer.

Breast cancer is the second most commonly diagnosed cancer worldwide, with the highest mortality of all cancers. In most cases, breast cancer is estrogen-dependent, which means cancer cells express estrogen receptors. Phytoestrogens, due to their structural similarities with estrogen, are capable of binding to estrogen receptors and are therefore also referred to as selective estrogen receptor modulators.

The role of microenvironmental pH regulation on colorectal cancer cells - a preliminary study.

The pH gradient inversion is one of the characteristic features of cancer cells. The acidic environment outside the tumor and the alkaline inside cancer cells significantly affect its growth and ability to metastasize and reduce the effectiveness of therapy. In this study, we examined the effect of the alkaline pH on the viability of colorectal cancer (CRC) cells Caco-2 and Ht-29, and normal human fibroblasts BJ-CRL-2522 as a control cell line.

Evaluation of the effectiveness and safety of the ultralight, non-resorbable Optomesh® ULTRALIGHT surgical meshes for surgical treatment of hernias based on open and laparoscopic techniques - a retrospective analysis.

Background: According to global data, hernia surgery is the most commonly performed elective surgical procedure. The primary factor that can lead to the development of a hernia is weakening of the abdominal wall. The only effective method of treating hernias, regardless of their type, is surgery.

Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials.

The unique properties of insect silk have attracted attention for years to develop scaffolds for tissue engineering. Combining natural silks with synthetic polymers may benefit biocompatibility, mechanical strength, and elasticity. Silk-modified biomaterials are a promising choice for tissue engineering due to their versatility, biocompatibility, and many processing methods.

Benefits of primary prophylaxis with letermovir in patients after allogeneic hematopoietic stem cell transplantation for hematologic malignancies.

Background: Introduction of letermovir (LMV) as prophylaxis for cytomegalovirus (CMV) infection has decreased the number of clinically significant CMV infections (cs-CMVi) in allogeneic hematopoietic stem cell transplantation (HSCT) recipients. However, long-term, real-world data on LMV's impact on post-transplant outcome remain scarce.

Research Design And Methods: The aim of our study was to evaluate clinical outcome of 93 CMV-seropositive patients who received LMV prophylaxis and to compare them to 168 LMV-free recipients.