A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli.

Peptidoglycan hydrolases facilitate bacterial cell wall growth by creating space for insertion of new material and allowing physical separation of daughter cells. In Escherichia coli, three peptidoglycan amidases, AmiA, AmiB and AmiC, cleave septal peptidoglycan during cell division. The LytM-domain proteins EnvC, NlpD and ActS activate these amidases either from inside the cell or the outer membrane: EnvC binds to the cytoplasmic membrane-anchored divisome components FtsEX, while NlpD and ActS are outer membrane-anchored lipoproteins.

Cost-utility analysis of latanoprost unidose cationic emulsion preservative-free versus latanoprost unidose in the treatment of open-angle glaucoma and ocular hypertension patients in Spain.

Background: This study evaluated the efficiency CE-latanoprost unidose (cationic emulsion of latanoprost) versus latanoprost unidose (non-emulsion formulation) in open-angle glaucoma and ocular hypertension (OAG/OHT) with concomitant ocular surface disease (OSD) patients' treatment in Spain.

Methods: A cost-utility analysis was performed using a Markov model simulating the progression of OAG/OHT. From a Spanish National Health System perspective over a 5-year time horizon, quality-adjusted life years (QALYs) and the total cost of each therapy were estimated (annual discount rate: 3%).

Complementary and Alternative Medicine (CAM) Use in Patients Undergoing Radiotherapy: Sex-specific Prevalence and Associations of Use Based on the S3 Guideline Complementary Medicine in Oncology Questionnaire.

Background/aim: This study aimed to assess the sex-specific prevalence and patterns of complementary and alternative medicine (CAM) use in patients undergoing radiotherapy, using the standardized questionnaire developed as part of the S3 Guideline on Complementary Medicine in Oncology.

Patients And Methods: Between August and December 2022, 112 out of 697 eligible cancer patients receiving radiotherapy were prospectively enrolled and completed a structured questionnaire assessing CAM use. The questionnaire included 38 CAM methods classified according to their potential for interactions.

Romidepsin and mogamulizumab sequential treatment for advanced cutaneous T-cell lymphoma.

Management of advanced stage cutaneous T-cell lymphoma (CTCL) can be challenging due to lack of durable responses to currently available therapies and their side effects and toxicities. Romidepsin, a histone deacetylase inhibitor, and mogamulizumab, an anti-CCR4 monoclonal antibody, have demonstrated some efficacy as monotherapies, however, survival outcomes remain poor. This retrospective study evaluates the effectiveness of sequential romidepsin-mogamulizumab (Romi-Moga) therapy in 18 patients with advanced CTCL.

essential genome and the divergence of cell division in the PVC superphylum.

The -- superphylum comprises bacteria with divergent traits, epitomizing the vast biodiversity of non-model organisms that remains unexplored. Among its members, and exhibit unique adaptations, including variations in peptidoglycan structure and cell division without FtsZ. represents the only name-giving phylum within the PVC not extensively investigated.