Natural-Based Nanocomposite Ink Engineering for Seamless Multi-Material Integration in Extrusion-Based 3D Printing.

Multi-tissue regeneration remains a critical clinical challenge due to the lack of solutions that can replicate the hierarchical heterogeneity of such complex interfaces. While biofabrication approaches, such as extrusion-based, allow replicating robust, biomimetic, and layered designs, constructs are usually hindered by inadequate phase/layer integration, poor filler dispersion, and mismatched rheological and mechanical performances. This study introduces an ink engineering strategy as a solution for integrating natural-based nanocomposites in multi-tissue regenerative approaches.

Liquid Chromatography Evaluation of a Novel Graphitic Carbon Stationary Phase Using Glucagon-Like Peptide‑1 Analogs.

Innovations in liquid chromatography stationary phase media can address emerging peptide separation and purification challenges. Herein, we report the synthesis of novel carbon microbeads from natural micrographite flakes as the starting material (referred to as All Carbon microbeads) and their performance as reversed-phase liquid chromatography stationary phase media using the glucagon-like peptide-1 (GLP-1) analogs semaglutide and liraglutide as probe analytes. High-performance liquid chromatography (HPLC) performance metrics were characterized and validated, including column efficiency measured by theoretical plate count (), as well as linear response, precision, limit of detection (LOD), limit of quantitation (LOQ), and loading capacity.

Innovative Strategies in Hernia Mesh Design: Materials, Mechanics, and Modeling.

Hernia is a physiological condition that significantly impacts patients' quality of life. Surgical treatment for hernias often involves the use of specialized meshes to support the abdominal wall. While this method is highly effective, it frequently leads to complications such as pain, infections, inflammation, adhesions, and even the need for revision surgeries.

Characterization of ferric hydroxysulfate on Mars and implications of the geochemical environment supporting its formation.

Sulfate minerals are significant components of the martian surface and provide clues about the martian geochemical environment. One unusual Fe-sulfate phase has been intriguing Mars scientists for over a decade due to its unique spectral bands that are distinct from any known minerals and its occurrence in layered sedimentary rocks. We describe here detection of ferric hydroxysulfate (FeSOOH) and its implications for the geochemical history of Mars.

Biomechanical Impact of Recurrent Childbirth on the Female Pelvic Floor.

Every year, millions of childbirths occur globally, yet the rate of maternal morbidity and mortality remains unacceptably high. This study investigates the biomechanical impact of multiple vaginal deliveries on pelvic floor dysfunction (PFD), a key contributor to maternal morbidity. While the effects of first childbirth on pelvic floor injuries have been widely studied, less is known about the impact of subsequent deliveries.