Elements of Visuopathy of Prematurity Are Unified by Intermittent or Sustained Systemic Inflammation.

We hypothesize that the major pathologies associated with the visual system in preterm infants, retinopathy of prematurity (ROP), cerebral visual impairment (CVI), and neurodevelopmental impairment (NDI), are unified by a common etio-pathogenesis involving intermittent and/or sustained systemic inflammation (ISSI). We refer to the resulting adverse visual outcomes (AVO) as "visuopathy of prematurity" (VOP). We present the published evidence supporting an etio-pathogenic paradigm centered around ISSI that begins before birth (early phase 1), is exacerbated in the newborn period (intermediate phase 2), and culminates in adverse visual and neurodevelopmental outcomes (late phase 3).

A rare case of severe bilateral chorioretinal coccidioidomycosis in an immunocompromised pediatric patient with Takayasu Arteritis.

Purpose: To report a case of severe bilateral coccidioidomycosis chorioretinitis in an immunosuppressed pediatric patient, demonstrating significant management challenges, therapeutic interventions, and a favorable outcome.

Observations: A 14-year-old female with a history of 1p36 microdeletion and Takayasu Arteritis (TA), managed with adalimumab and mycophenolate, presented with acute respiratory symptoms and bilateral vision impairment. She had severe bilateral diffuse chorioretinitis and an anterior chamber sample revealed coccidioidomycosis.

Involving neonatal hematology and transfusion medicine in global efforts to eliminate severe retinopathy of prematurity.

Retinopathy of Prematurity (ROP) remains a worldwide problem. A more complete understanding of the pathogenesis might inform progress toward its elimination. ROP pathogenesis is undeniably complex, including preterm birth and oxygen exposure, but many other factors are implicated as well.

Genotypic Distribution and Clinical Correlations in Familial Exudative Vitreoretinopathy: A Single-Center Study.

Purpose: To report the role of wide-angle imaging in detecting suspicious cases of familial exudative vitreoretinopathy (FEVR) in pediatric patients with unexplained vision loss and describe genotypic distribution and examples of phenotypes.

Design: A retrospective cohort study was conducted at a single tertiary referral center in the Intermountain West.

Subjects And Participants: Patients diagnosed with FEVR or atypical retinopathy of prematurity (ROP) between 2010 and 2021 at the University of Utah.