Prevalence of germline pathogenic variants in 779 patients with metastatic prostate cancer.

Objective: To assess the prevalence of germline pathogenic variants (gPVs) in genes associated with female breast cancer in Dutch patients with metastatic prostate cancer (mPCa).

Patients And Methods: In this prospective multicentre cohort study (n = 15 centres), germline genetic testing of the genes BRCA1, BRCA2, ATM, CHEK2 and PALB2 was offered to patients with mPCa. We assessed the prevalence of gPVs and compared it to a reference population of 16 823 individuals who underwent genetic testing for non-oncological conditions.

Antibiotic Prophylaxis Is Not Required Before MRI-Guided Transperineal Prostate Biopsy.

Objective: To evaluate rates of infectious and non-infectious complications after transperineal prostate biopsy (TPBx) without antibiotic prophylaxis (ABP) and to identify potential risk factors for post-biopsy infections.

Methods: We conducted an observational cohort study among patients who underwent TPBx without ABP at two high-volume diagnostic prostate cancer centers in an outpatient setting between February 2020 and October 2023. The primary outcome was post-TPBx infection, defined as an antibiotic prescription for urinary tract infection within 2 weeks post-biopsy or inpatient care for infection within 30 days.

How to integrate physiological data from wearables in treatment of personality disorders: a narrative review.

In recent years, stress-monitoring innovations using wearable technology have entered the market. One innovation is biocueing, a process where patients receive real-time feedback on passive monitoring of significant changes in their physiological data, such as (additional) heart rate, heart rate variability or skin conductance. This technology offers potential for patients with borderline personality disorder, as they often report severe stress, difficulties in emotion regulation and low levels of emotional- and body awareness.

Stress in action wearables database: A database of noninvasive wearable monitors with systematic technical, reliability, validity, and usability information.

Ambulatory wearable monitoring of human physiology is increasingly utilized in the fields of psychology, movement sciences, and medicine. With the rapid growth of available consumer- and research-oriented wearables, researchers are faced with a multitude of devices to choose from. It is unfeasible timewise for researchers to determine all relevant technical specifications, available signals, signal sampling details, and (raw) data availability, and conduct a search of studies regarding the reliability, validity, and usability of wearables.

Experience of urologists, oncologists and nurse practitioners with mainstream genetic testing in metastatic prostate cancer.

Background: International guidelines recommend germline genetic testing for men with metastatic prostate cancer. If offered to all patients by genetic healthcare professionals, there will be insufficient capacity to cope with the high patient numbers. In a mainstreaming pathway, non-genetic healthcare professionals (ngHCPs) discuss and order germline genetic testing instead of referring patients to genetic healthcare professionals.