Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport.

The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay and liquid chromatography-mass spectrometry-based proteomics we explored the plasma proteins associating with the difference in 100 extreme scoring individuals selected from two large population cohorts, the Leiden Longevity Study (LLS) and the Rotterdam Study (RS), and discordant monozygotic twin pairs from the Netherlands Twin Register (NTR).

Human plasma-derived exosomal gel: a biomimetic cargo for the transdermal delivery of methotrexate.

The aim of the study was to explore the potential of human plasma-derived exosomal gel as a carrier for transdermal drug delivery. Exosomes were isolated from human plasma through a combination of ultracentrifugation and dialysis techniques. Methotrexate (MTX), a weak acid drug with log P 1.

ROS Regulation and Antioxidant Responses in Plants Under Air Pollution: Molecular Signaling, Metabolic Adaptation, and Biotechnological Solutions.

Air pollution acts as a pervasive oxidative stressor, disrupting global crop production and ecosystem health through the overproduction of reactive oxygen species (ROS). Hazardous pollutants impair critical physiological processes-photosynthesis, respiration, and nutrient uptake-triggering oxidative damage and yield losses. This review synthesizes current knowledge on plant defense mechanisms, emphasizing the integration of enzymatic (SOD, POD, CAT, APX, GPX, GR) and non-enzymatic (polyphenols, glutathione, ascorbate, phytochelatins) antioxidant systems to scavenge ROS and maintain redox homeostasis.

Process intensification of anaerobic digestion for biohydrogen and methane production from crude glycerol and dairy wastewater using cavitation techniques.

This study investigates methane production from the mono-digestion of dairy wastewater (DWW) and hydrogen production from the co-digestion of DWW and crude glycerol (CG), both of which are abundantly available in India. In this study, ultrasonication (US) and hydrodynamic cavitation (HC) were employed as pretreatment methods for DWW prior to mono and co-anaerobic digestion, with the aim of enhancing methane and hydrogen production. The results show that these methods significantly improve methane yield, offering a sustainable solution for efficient bioenergy recovery from organic waste.