I-DMSO-mediated [4 + 2] cyclization of methyl ketone with 2-aminobenzimidazole to construct 2,4-disubstituted benzo[4,5]imidazo[1,2-] pyrimidines.

A novel and efficient synthesis of 2,4-disubstituted benzo[4,5]imidazo[1,2-]pyrimidine skeletons is reported. Using 2-aminobenzimidazole and acetophenone as substrates, an I-DMSO-mediated multicomponent reaction was described, which used a one-pot method to generate two C-N bonds and one C-C bond, yielding 25 substrates. Currently, such derivatives are used clinically for biorevealing, so we selected some of the compounds in this paper for photophysical characterization.

Synthesis of Substituted of Benzo[4,5]imidazo[1,2-]pyrimidines through (3 + 2+1) Cyclization of 2-Aminobenzimidazole, Acetophenone, and ,-Dimethylformamide as One-Carbon Synthon.

An efficient method for the construction of benzo[4,5]imidazo[1,2-]pyrimidines using ,-dimethylformamide as a one-carbon source and 2-aminobenzimidazoles and acetophenone as substrates through a one-pot, three-component cascade reaction is described. Spectra investigations indicated the fluorescent properties of selected products, exhibiting quantum yields 0.07-0.