The Cathepsin Family in Disease: From Molecular Mechanisms to Therapeutic Applications.

The cathepsin family of proteolytic enzymes is involved in the maintenance of major physiological processes, including protein degradation, immune modulation, tissue remodeling, and apoptosis. Members of the cathepsin family include cysteine, serine, and aspartic proteases, which are implicated in diverse cellular functions. Evidence for tissue-specific expression emphasizes the specialized functions of these enzymes in many organs.

Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic.

This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, and medical device production. It also assesses economic, environmental, and ethical considerations. In our review of the literature, we employed a comprehensive search strategy, utilizing well-known databases like PubMed and Google Scholar.

A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles.

Background: Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition.

Objectives: The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold.

Synthesis, Antibacterial Evaluation and QSAR of α-Substituted-N₄-Acetamides of Ciprofloxacin and Norfloxacin.

Twenty six α-substituted N₄-acetamide derivatives of ciprofloxacin (CIPRO) and norfloxacin (NOR) were synthesized and assayed for antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis. The derivatives were primarily more active against Gram-positive bacteria. The CIPRO derivatives, CD-7 (Ar = 3-chlorophenyl), CD-9 (Ar = 2-pyrimidyl) and CD-10 (α-phenyl, Ar = 2-pyrimidyl), exhibited lower MIC values, 0.