Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium.

Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain itself. An increasingly popular approach to address this is by combining epigenetic and neuroimaging data; yet, research in this area is almost entirely comprised of cross-sectional studies in adults.

Insomnia and sleepiness during pregnancy: Associations with gestational diabetes mellitus.

Introduction: Sleep quality typically deteriorates during pregnancy, and poor sleep is a risk factor for pregnancy complications, including gestational diabetes mellitus (GDM). The present study is the first longitudinal study addressing associations between sleep quality and GDM at separate time-points throughout the pregnancy.

Material And Methods: This study was a part of the FinnBrain cohort, including 3808 pregnant women.

Latent Profiles of Early Language Development in a Large Finnish-Speaking Sample of the FinnBrain Birth Cohort Study.

Purpose: Research on early language development has primarily used two categories to group at-risk children, differing by the age at which risk is identified. Late talkers are toddlers with late onset of language development, some of whom may catch up with peers. Developmental language disorder is used to refer to children above the age of 4 years.

Paternal adverse childhood experiences and offspring's attentional disengagement from faces at 8 months-Results from the FinnBrain Birth Cohort Study.

Paternal adverse childhood experiences (ACEs) have been recently linked to offspring's brain development. Yet, none of the previous studies in humans have explored the association between paternal ACEs and a child's attentional bias for facial expressions of emotion. Our study fills this gap.

Gestational diabetes mellitus and children's social-emotional development, behavioral problems, and psychological adjustment.

Background: This longitudinal cohort study investigated whether gestational diabetes mellitus (GDM) is associated with 2- and 5-year-old children's social-emotional development and whether child sex moderates the association.

Methods: FinnBrain Birth Cohort Study recruited 3808 pregnant women 2011-2015 in Finnish Turku region and Åland Islands. Their children's social-emotional development at 2 years was measured by Brief Infant Toddler Social Emotional Assessment (BITSEA) (N = 1444, GDM n = 227) and at 5 years by Strengths and Difficulties Questionnaire (SDQ) (N = 1489, GDM n = 225).

Associations of Leukocyte Telomere Length With Trait Resilience, Adverse Childhood Experiences, and Psychological Distress Among Expecting Parents in the FinnBrain Birth Cohort.

Background: Telomere attrition has previously been associated with mental health problems and adverse childhood experiences (ACEs). Resilience has been shown to protect against mental health problems even in the context of ACEs. In this study, we examined the associations between leukocyte telomere length (LTL), symptoms of psychological distress, ACEs, and trait resilience.

Longitudinal study of factors predicting toothbrushing less than twice daily at age 2 years in the FinnBrain Birth Cohort Study.

We aimed to identify factors predicting toothbrushing less than twice daily at the age of 2 years. The data from the FinnBrain Birth Cohort Study of 506 mother-father pairs (with 506 children) were used. Logistic regression analyses were conducted of the outcome (brushing less than twice daily) at the age of 24 months.

Effect of gestational anemia on breastfeeding- a prospective follow-up -study.

Background: Gestational anemia is a common pregnancy complication that affects approximately 40% of pregnant women globally. The health benefits of breastfeeding are widely acknowledged for both mothers and infants, and recognizing the factors that affect the duration and quality (exclusive / partial) of breastfeeding is therefore of great importance.

Methods: Women who participated in the FinnBrain Birth Cohort during 2011-2015 and whose hemoglobin levels were available in the third trimester (n = 1238) were included in this prospective study.

Post-traumatic stress disorder and its associated factors: a cross-sectional study among refugee children and adolescents living in a Ugandan refugee settlement.

The prevalence of post-traumatic stress disorder (PTSD) and its risk factors among adult refugees in the context of war-related forced migration is well established. However, reliable data are lacking on war-related trauma among refugee children and adolescents residing in refugee settlements. This study estimated the magnitude of PTSD and its associated factors among children and adolescents in Nakivale refugee settlement, south-western Uganda.

Measuring adverse childhood experiences by interviewing children at 9 and 10 years of age: Prevalence, concordance with mother-reports, posttraumatic stress disorder symptoms, and subjective experience of being asked about adverse childhood experiences in FinnBrain Birth cohort study.

How children experience the screening of adverse childhood experiences (ACEs) is little studied. Moreover, the similarity between parental and child reports is unknown. We interviewed 9-year-olds (a subsample of the FinnBrain Birth Cohort Study; N = 344) by using the Pediatric ACEs and Related Life Events Screener questionnaire (PEARLS; covering 10 traditional ACEs and 7 expanded items).

The FinnBrain multimodal neonatal template and atlas collection.

The accurate processing of neonatal and infant brain MRI data is crucial for developmental neuroscience but presents unique challenges that child and adult data do not. Tissue segmentation and image coregistration accuracy can be improved by optimizing template images and related segmentation procedures. Here, we describe the construction of the FinnBrain Neonate (FBN-125) template, a multi-contrast template with T1- and T2-weighted, as well as diffusion tensor imaging-derived fractional anisotropy and mean diffusivity images.

Infant Subcortical Brain Volumes Associated with Maternal Obesity and Diabetes: A Large Multicohort Study.

Importance: Maternal diabetes (MD) and maternal obesity (MO) have been robustly established to confer health risks in offspring. Additionally, mounting evidence suggests that these fetal programming effects vary by sex, but whether these factors independently or interactively influence infant brain development remains unclear.

Objectives: To characterize interactions between MD, MO, and sex on offspring subcortical brain volumes.

Changes in Oral Health-Related Quality of Life According to Public Oral Health Procedures in Parents of Young Children From the FinnBrain Birth Cohort Study.

Objectives: The aim was to evaluate the association between public oral healthcare procedures and change in oral health-related quality of life (OHRQoL) over 4 years among parents in the FinnBrain Cohort Study, comparing those who did not visit public oral healthcare.

Methods: The study used data on parents of young children from the FinnBrain Birth Cohort Study (www.finnbrain.

Associations between maternal pre-pregnancy BMI and mean diffusivity of the hippocampus and amygdala in infants.

Background: Maternal pre-pregnancy obesity may negatively affect offspring outcomes, including neurodevelopment. This study examined the relationship between maternal pre-pregnancy body mass index (MBMI) and the microstructure of the hippocampus and amygdala in neonates.

Methods: Diffusion tensor imaging was used to assess mean diffusivity (MD) in these brain regions in 122 infants (mean gestational age: 39.

Maternal Emotional Availability Supports Child Communicative Development Regardless of Child Temperament-Findings From the FinnBrain Birth Cohort Study.

The interplay of emotional availability (EA) and child temperament in association with early language development is understudied. We explored associations between maternal EA and infant communicative development and possible moderations by child temperament. Participants were 151 mother-child dyads from the FinnBrain Birth Cohort Study.

Gestational Duration and Postnatal Age-Related Changes in Aperiodic and Periodic Parameters in Neonatal and Toddler Electroencephalogram (EEG).

The brain develops most rapidly during pregnancy and early neonatal months. While prior electrophysiological studies have shown that aperiodic brain activity undergoes changes across infancy to adulthood, the role of gestational duration in aperiodic and periodic activity remains unknown. In this study, we aimed to bridge this gap by examining the associations between gestational duration and aperiodic and periodic activity in the EEG power spectrum in both neonates and toddlers.

Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm.

Childhood maltreatment exposure (CME) increases the risk of adverse long-term health consequences for the exposed individual. Animal studies suggest that CME may also influence the health and behaviour in the next generation offspring through CME-driven epigenetic changes in the germ line. Here we investigated the associated between early life stress on the epigenome of sperm in humans with history of CME.

Association Between the Two-Year Trajectories of Dental Anxiety and the Changes in the Oral Health-Related Quality of Life in Parents of FinnBrain Birth Cohort Study.

: We evaluated associations between changes in dental anxiety and oral health-related quality of life (OHRQoL) in parents of the FinnBrain Birth Cohort Study. : Two-year dental anxiety trajectories measured with Modified Dental Anxiety Scale from gestational weeks (gw) 14 and 34, and 3 and 24 months after birth were used. OHRQoL was measured with the Oral Health Impact Profile 14-item questionnaire at gw34 and 4 years.

Understanding Resilience in Parents: Longitudinal Examination of Trait Resilience, Stressful Life Events, and Psychological Distress Symptoms-Insights From the FinnBrain Study.

The study aimed to investigate the persistence or changes in trait resilience of parents over a 6-year period and its association with stressful life events (SLEs). Furthermore, we explored the potential protective effect of trait resilience against exposure to stressful life events and their negative mental health consequences. The study population was drawn from the ongoing FinnBrain Birth Cohort Study and included 1388 mothers and 657 fathers who completed the CD-RISC-10 questionnaire during pregnancy and again 6 years later.

Simulated ischaemia/reperfusion impairs trophoblast function through divergent oxidative stress- and MMP-9-dependent mechanisms.

Early-onset pre-eclampsia is believed to arise from defective placentation in the first trimester, leading to placental ischaemia/reperfusion (I/R) and oxidative stress. However, our current understanding of the effects of I/R and oxidative stress on trophoblast function is ambiguous in part due to studies exposing trophoblasts to hypoxia instead of I/R, and which report conflicting results. Here, we present a model of simulated ischaemia/reperfusion (SI/R) to recapitulate the pathophysiological events of early-onset pre-eclampsia (PE), by exposing first trimester cytotrophoblast HTR-8/SVneo cells to a simulated ischaemia buffer followed by reperfusion.

Cognitive interviews on the Swedish occupational balance questionnaire.

Background: The Occupational Balance Questionnaire (OBQ11) is a commonly used instrument for measuring self-rated occupational balance. It needs further development, and therefore an additional 11 tentative items have been developed. One aspect of this is studying the interpretations and reasoning of people responding to the items/instrument.