Publications by authors named "Linjian Weng"
Energy is a crucial component for maintaining egg production in layers. The hypothalamic-pituitary-ovarian (HPO) axis is an energy-sensitive functional axis for follicle development, synthesis, and secretion of reproductive hormones, and plays a key role in modulating sustained ovulation in layers. To investigate the mechanism of integrated network regulation of the HPO axis under energy fluctuation, ninety Hy-line brown layers (265-day-old, 1.
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- Argonaute proteins play a crucial role in regulating gene expression by binding to small RNAs across various organisms, with vertebrates having two main clades: Ago and Piwi.
- Both clades contain essential domains like N, L1, L2, PAZ, MID, and PIWI that facilitate the loading and anchoring of sRNAs, with some Piwi proteins also having endonuclease functions.
- Recent advancements have enhanced our understanding of their structures, functions, and gene regulation roles, particularly in relation to epigenetic regulation and potential research applications.
Article Synopsis
- The study investigates how poultry (specifically laying hens) adapt their metabolism in response to energy deprivation caused by fasting and refeeding practices.
- Ninety hens were divided into three groups: a control group with constant feeding, a fasting group, and a refeeding group, with various analyses of their bodily responses conducted after the treatment.
- Findings revealed that fasting led to significant changes in body weight, gut microbiota composition, and liver gene expression, all of which were reversed by refeeding, indicating a complex interaction between the gut, liver, and metabolic processes.
Background: Fatty liver hemorrhagic syndrome (FLHS) in the modern poultry industry is primarily caused by nutrition. Despite encouraging progress on FLHS, the mechanism through which nutrition influences susceptibility to FLHS is still lacking in terms of epigenetics.
Results: In this study, we analyzed the genome-wide patterns of trimethylated lysine residue 27 of histone H3 (H3K27me3) enrichment by chromatin immunoprecipitation-sequencing (ChIP-seq), and examined its association with transcriptomes in healthy and FLHS hens.