NRF2 inhibition of alveolar macrophage MHC II expression during infection.

During (Mtb) infection, infected alveolar macrophages (AMs) initially up-regulate a NRF2 regulated cell-protective program, which is detrimental to host control and impedes AM activation, including MHC II expression. MHC II is critical for CD4 T cell activation and host immunity during Mtb infection. We hypothesized that NRF2 regulates the MHC II pathway and AM antigen presentation to T cells.

Evidence-based interventions targeting mental health problems in adolescents living with HIV: a scoping review.

Adolescents living with HIV are at an increased risk of experiencing mental health challenges, impacting their overall well-being and treatment adherence. Evidence-based interventions are crucial to addressing these issues; however, the effectiveness remains unclear. This scoping synthesised all interventions that tested either the prevention or improvement of mental health for adolescents living with HIV.

Development and external validation of a machine learning model for predicting drug-induced immune thrombocytopenia in a real-world hospital cohort.

Background: Drug-induced immune thrombocytopenia (DITP) is a rare but potentially life-threatening adverse drug reaction, often underrecognized due to its nonspecific presentation and the lack of real-time diagnostic tools. Early identification of at-risk patients is critical to improving medication safety and preventing severe complications.

Objective: To develop and externally validate a machine learning model for predicting the risk of DITP using routinely collected hospital data, and to optimize its clinical applicability through threshold adjustment.

A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.

Background: Structural covariance within the brain is thought to reflect inter-regional sharing of developmental influences. This hypothesis has proved difficult to test but can be informatively probed by the study of sex differences. Here, we use neuroimaging in humans and mice to study sex-differences in anatomical covariance- asking (1) are there sex differences in structural covariance and (2) do regions that share the same developmental influences, as exhibited by shared sex differences in volume, also show shared sex differences in volume covariance.

Virulence Potential of Nonclinical Vibrio parahaemolyticus Isolates From Vietnam: Evidence for Functional T3SS2-Mediated Enterotoxicity.

Vibrio parahaemolyticus is a leading cause of seafood-borne gastroenteritis worldwide, and its pathogenic strains typically harbor thermostable direct hemolysin (TDH) and type III secretion system 2 (T3SS2). Although these virulence factors are associated primarily with clinical isolates, their presence in nonclinical environmental and food isolates raises concerns about their potential infection risk. In this study, we investigated the pathogenic potential of nonclinical V.

Effects of 810 nm treatments in acute myofiber contraction of C2C12 myotubes.

The muscoskeletal system can be irradiated with wavelengths in the red and near infrared regions which penetrate deep into the body and stimulate biological mechanisms. However, the activation of cellular responses in muscle, specifically actively contracting, is not clearly understood. Therefore, we investigated biological effects induced by irradiation with 810 nm wavelength of light in myotubes, resting or actively contracting in an acute model of exercise.

Substances of Health Concern: Label Accuracy of Cannabidiol and Tetrahydrocannabinol in Commercial Cannabidiol Tinctures from the United States.

In recent years, the production and consumption of cannabinoids have increased significantly. Researchers are particularly interested in cannabidiol (CBD), Δ-tetrahydrocannabinol (Δ-THC), and Δ-tetrahydrocannabinol (Δ-THC). Despite the growing prevalence of these molecules in everyday life, research shows that cannabinoid products are often mislabeled.

Development of 9-cinnamyl-9H-purine derivatives as potent anticancer agents through inactivation of NF-κb/p65 and p-STAT1 signaling pathways: Discovery of a new template for adenosine receptor.

Based on the structure of resveratrol and curcumin, a novel 9-cinnamyl-9H-purine structure was designed and synthesized to avoid a pan-assay interference compound (PAINS) related to invalid metabolic pancreas activity (IMPS). In a previous study, it exhibited anti-inflammatory activities by disrupting the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway. In this study, further structure-activity relationship studies were conducted to evaluate 9-cinnamyl-9H-purine derivatives for their potential anticancer activities, as NF-κB inhibition is known to reduce tumor growth and increase cancer cell death.

Ultrasound-Guided Fine-Needle Aspiration Biopsy Of Thyroid Nodules Smaller Than 10 mm in the Maximum Diameter: The Efficacy and Its Correlation with TIRADS Classification.

Objective: This retrospective study evaluated the effectiveness of ultrasound-guided fine-needle aspiration cytology (US-FNAc) for diagnosing thyroid nodules less than 10mm and explored the correlation between the TIRADS classification and US-FNAc reports.

Methods: This analysis of 344 patients with 407 thyroid nodules less than 10mm was conducted from June 2022 to July 2023 at the Centre of Endocrinology and Diabetes, Danang Family hospital, Danang, Vietnam. US-FNAc was performed on all nodules, and cytology was reported according to The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).

Inhibitory effect of exercise on elevated blood pressure and fetal growth restriction during pregnancy in Dahl salt-sensitive rats.

Exercise is effective in preventing gestational hypertension, but its mechanism remains unclear. This study investigates the effects of exercise on Dahl salt-sensitive (DSS) rats, which develop elevated blood pressure and fetal growth restriction during pregnancy. DSS rats were divided into exercise and non-exercise groups, with Sprague-Dawley rats as controls.

Impact of Ginkgo biloba drug interactions on bleeding risk and coagulation profiles: A comprehensive analysis.

This retrospective observational study was conducted to investigate the prevalence and clinical implications of drug interactions involving Ginkgo biloba extract on bleeding risk and coagulation profiles. Our analysis utilized data from patients admitted to Hai Phong International Hospital between January 2022 and December 2023. Inclusion criteria consisted of patients aged 18 years and above, those prescribed Ginkgo biloba extract alone or in combination with other medications, and the availability of complete medical records, including medication history, laboratory tests, and clinical outcomes.

Multilevel mortality risk factors among pediatric hematology-oncology patients with deterioration.

Background: Hospitalized pediatric hematology-oncology patients have frequent clinical deterioration events (CDEs) requiring intensive care unit (ICU) interventions and resulting in high mortality, particularly in resource-limited settings. This study identifies independent risk factors for CDE mortality in hospitals providing childhood cancer care in Latin America and Spain.

Methods: Centers implemented a prospective CDE registry, defined as unplanned transfer to a higher level of care, use of ICU-level interventions on the ward, or nonpalliative ward death.

Developing a machine learning-based predictive model for levothyroxine dosage estimation in hypothyroid patients: a retrospective study.

Hypothyroidism, a common endocrine disorder, has a high incidence in women and increases with age. Levothyroxine (LT4) is the standard therapy; however, achieving clinical and biochemical euthyroidism is challenging. Therefore, developing an accurate model for predicting LT4 dosage is crucial.

Preliminary Results of the Efficacy and Safety of Cryoablation for Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation: a Study From Vietnam.

Background: Atrial fibrillation is the most common type of arrhythmia. The symptoms of atrial fibrillation not only significantly impacted quality of life but also associated with thrombotic events and heart failure, thereby increased risk of mortality. According to current guidelines, the initial treatment strategy for patients with atrial fibrillation is antiarrhythmic medication.

Correction: A navigational risk evaluation of ferry transport: Continuous risk management matrix based on fuzzy Best-Worst Method.

[This corrects the article DOI: 10.1371/journal.pone.

Evidence-based interventions targeting mental health problems in adolescents living with HIV: A scoping review.

Introduction: Adolescents living with HIV are at an increased risk of experiencing mental health challenges, which may impact their overall well-being and adherence to treatment. Evidence-based interventions are crucial to addressing these issues; however, the effectiveness of these interventions remains unclear. This scoping review aimed to synthesize all interventions that tested either the prevention or improvement of mental health for adolescents living with HIV.

Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages.

Alveolar macrophages (AMs) are lung-resident myeloid cells and airway sentinels for inhaled pathogens and environmental particles. While AMs can be highly inflammatory in response to respiratory viruses, they do not mount proinflammatory responses to all airborne pathogens. For example, we previously showed that AMs fail to mount a robust proinflammatory response to Mycobacterium tuberculosis.

Feedback receptivity from people in power reduces gender, sexual orientation, and disability bias concerns.

Seven preregistered studies (total = 2,443) demonstrate that feedback receptivity of people in power, or their openness to feedback, reduces bias concerns among members of marginalized groups (marginalized group meta-analytic = 0.53; nonmarginalized group meta-analytic = 0.10).

Potential role of signal transducer and activator of transcription 3 in the amygdala in mitigating stress-induced high blood pressure via exercise in rats.

Aim: Chronic stress elevates blood pressure, whereas regular exercise exerts antistress and antihypertensive effects. However, the mechanisms of stress-induced hypertension and preventive effects through exercise remain unknown. Thus, we investigated the molecular basis involved in autonomic blood pressure regulation within the amygdala.

Association between underlying health conditions and long COVID among non-hospitalized and hospitalized individuals as modified by health literacy: A multi-center study.

Objectives: We investigated the effect modification of health literacy (HL) in ameliorating the negative impact of underlying health conditions (UHC) on long COVID among non-hospitalized and hospitalized survivors.

Study Design: An online cross-sectional study was conducted in Vietnam from December 2021 to October 2022.

Methods: A sample of 4507 participants recruited from 18 hospitals and health centers were those aged 18 or older, had contracted COVID-19 for at least 28 days, and were not in the acute phase of reinfection.

Fear and Impact of COVID-19 Among Post-Infected Adults: Types and Associations with Quality of Life and Post-Traumatic Stress Symptoms.

Survivors of COVID-19 are susceptible to diminished health-related quality of life (HRQoL) and adverse psychological health, which may be exacerbated by their experiences of fear and the impact of the pandemic itself. This study aims to identify distinct fear and impact patterns related to the COVID-19 pandemic among survivors through latent profile analysis (LPA) and examine the associations of fear and impact patterns with post-traumatic stress symptoms (PTSS) and HRQoL. A total of 5,890 Vietnamese COVID-19 survivors completed the COVID-19 Impact Battery- Disability Scale (CIB-D), the Fear of COVID-19 Scale (FCoV-19 S), the Impact of Event Scale-Revised for PTSS, and the 36-Item Short Form Survey (SF-36) for HRQoL.

A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.

Structural covariance in brain anatomy is thought to reflect inter-regional sharing of developmental influences - although this hypothesis has proved hard to causally test. Here, we use neuroimaging in humans and mice to study sex-differences in anatomical covariance - asking if regions that have developed shared sex differences in volume also show shared sex differences in volume covariance. This study design illuminates both the biology of sex-differences and theoretical models for anatomical covariance - benefitting from tests of inter-species convergence.

Characteristic of 24-Hour Blood Pressure Dipping Patterns in Hypertensive Stroke Patients.

Objective: We conducted a study titled for Investigation on the characteristics of 24-hour blood pressure (BP) dipping patterns in hypertensive stroke patients.

Methods: Descriptive research, analysis, and comparison, the research was conducted from July 2019 to September 2020 at the Vietnam Heart Institute - Bach Mai Hospital. There are 100 patients diagnosed with idiopathic hypertension who were divided into two groups (without stroke complications and another group with chronic stroke complications > 6 weeks), both groups were similar in age (45-64 years old).

Mitogenomics of the zoonotic parasite and insights into the evolution of tandem repeat regions within the mitochondrial non-coding control region.

is a cosmopolitan parasite within the Echinostomatidae and is a cause of human echinostomiasis. Species within the family have been a challenge to disentangle with being synonyms of several other species. However, complete mitochondrial genomes have been shown to be vital in distinguishing echinostomatid species, but detailed comparisons of not only gene content but also structural features have been limited.