Cobalt-Doped Carbon Quantum Dots Work Synergistically with Weak Acetic Acid to Eliminate Antimicrobial-Resistant Bacterial Infections.

When pathogenic bacteria colonize a wound, they can create an alkaline ecological niche that selects for their survival by creating an inflammatory environment restricting healthy wound healing to proceed. To aid healing, wound acidification has been exploited to disrupt this process and stimulate fibroblast growth, increase wound oxygen concentrations, minimize proteolytic activity, and restimulate the host immune system. Within this study, we have developed cobalt-doped carbon quantum dot nanoparticles that work together with mild acetic acid, creating a potent synergistic antimicrobial therapy.

The role of providers' intrinsic motivation for quality of care and responses to a non-financial incentive.

Providers' intrinsic motivation is deemed important for quality of care and responses to incentives. Building on self-determination theory, we test the hypotheses that more intrinsically motivated providers perform better and respond less to an external incentive. We exploit the introduction of a cluster randomised accreditation scheme in Danish general practice, where practices were randomised to accreditation in different years (2016-2018) at municipality level.

Mortality among patients with long-term prescription opioid use in Norway: a nationwide registry-based cohort study.

The aim was to estimate all-cause and cause-specific mortality in long-term prescription opioid users compared to the general population. This nationwide registry-based cohort study used data of patients aged 15 to 69 years with no previous cancer diagnosis and a recorded episode of long-term opioid analgesics use (anatomical therapeutic chemical [ATC] group N02A; N = 116,006) in Norway between 2011 and 2019. Sex-specific crude mortality rates (CMR) and age-standardized mortality ratios (SMRs) were calculated for all-cause and cause-specific mortality, ie, natural and unnatural causes for the whole study population and for different age groups (15-34, 35-54, and 55-69 years).

In Vivo Anatomical Variations in the Lateral Femoral Cutaneous Nerve in Children.

Background: The anatomic pathways of the lateral femoral cutaneous nerve (LFCN) have primarily been reported in adult in vitro populations with limited branching patterns. Children with hip disorders may require surgical treatment with an anterior approach, and the LFCN is a structure at risk. The aim of our study was to photographically verify the initial six-centimeter pathway of the LFCN in children measured from its appearance at the anterior superior iliac spine (ASIS).

Persistent use of high-dose opioids and other addictive medications.

Background: Persistent use of high-dose opioids increases the risk of overdose, particularly when used in combination with other sedatives. The aim of the study was to examine the number of people with persistent use of high-dose opioids in 2011 and 2019, the proportion who received the opioids on a 'blue prescription' (heavily subsidised prescription) and the proportion with concurrent persistent use of benzodiazepines and z-hypnotics.

Material And Method: Persistent use of high-dose opioids was defined as the dispensing of more than two defined daily doses or 50 mg of oral morphine equivalents of opioids per day, in at least three out of four quarters.

Experiences of quality cluster meetings in general practice - Findings from a national survey two years after initiation of quality clusters in Denmark.

Background: A new national model for quality improvement in general practice based on the concept of quality clusters was introduced in Denmark in 2018. A quality cluster is a local group of general practitioners (GPs) meeting regularly to engage in quality improvement on self-selected topics.

Aim: To explore (1) GPs' experiences of cluster meetings, and (2) associations between meeting experiences and self-reported benefits of participation.

Socioeconomic characteristics and relapse-free and overall survival from childhood cancer - a nationwide study based on data from the Danish Childhood Cancer Registry.

Background And Purpose: Over the past decades, childhood cancer survival has increased substantially in Europe, including Denmark. However, families with fewer social resources may have benefitted less from these improvements. In this nationwide register-based study, we assessed associations between parental socioeconomic position (SEP) and 5-year relapse-free survival (RFS) and overall survival (OS) in childhood cancer patients.

Patients' Health-Related Quality of Life and Use of Medicinal Cannabis: A Cross-Sectional Survey Study.

Background: Studies on medicinal cannabis (MC) have primarily investigated effects on diseases and symptoms, while there is only sparse knowledge on patients' health-related quality of life. Our aim was, firstly, to compare the health-related quality of life of patients (MC users and non-users) within four specified diagnostic indications (multiple sclerosis, paraplegia, neuropathy, and nausea and vomiting after chemotherapy) with that of patients with other diagnostic indications (MC users only) and the adult population (non-users only). Secondly, we estimate the associations between use of MC and health-related quality of life for patients in the four specified diagnostic indications.

Prevalence of substance use disorder diagnoses in patients with chronic pain receiving reimbursed opioids: An epidemiological study of four Norwegian health registries.

Objectives: Since 2008, patients have had access to reimbursed analgesics, including opioids, for chronic pain in Norway. There is a need for knowledge on the occurrence and trends over time of substance use disorder (SUD) diagnoses among patients who receive reimbursed opioids for chronic pain. The primary aim of this study was to investigate the prevalence of SUD diagnoses in patients with chronic pain using reimbursed opioids from 2010 to 2019 in Norway.

Contactless and continuous monitoring of respiratory rate in a hospital ward: a clinical validation study.

Introduction: Continuous monitoring of respiratory rate in hospital wards can provide early detection of clinical deterioration, thereby reducing mortality, reducing transfers to intensive care units, and reducing the hospital length of stay. Despite the advantages of continuous monitoring, manually counting every 1-12 h remains the standard of care in most hospital wards. The objective of this study was to validate continuous respiratory rate measurements from a radar-based contactless patient monitor [Vitalthings Guardian M10 (Vitalthings AS, Norway)] in a hospital ward.

General practitioners' barriers to cross-sectoral collaboration on pregnant women with vulnerabilities: a cross-sectional survey in Danish general practice.

Background: Pregnancy vulnerability contributes to poor perinatal mental health. Proper cross-sectoral collaboration may mitigate perinatal mental health problems. General practitioners (GPs) often face barriers when assessing pregnancy vulnerability, but little is known about GPs' perceived barriers to the cross-sectoral collaboration on vulnerable pregnant women.

Attitudes towards risk-stratified breast cancer screening in Denmark - a qualitative study.

Background: Today the prerequisites exist to initiate risk-stratified screening according to a woman's individual risk of breast cancer as opposed to existing one-size-fits-all age-based programmes. This presupposes that the women accept having their personal risk score estimated and their screening intervals changed accordingly. Risk-stratified screening has not yet been implemented in any country, but in the future many European countries will very likely move towards more personalized screening.

Clinical effects of accreditation in general practice: a pragmatic randomized controlled study.

Background: Accreditation has been implemented in general practice in many countries as a tool for quality improvement. Evidence of the effects of accreditation is, however, lacking.

Aim: To investigate the clinical effects of accreditation in general practice.

Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants.

Unstable proteins are prone to form non-native interactions with other proteins and thereby may become toxic. To mitigate this, destabilized proteins are targeted by the protein quality control network. Here we present systematic studies of the cytosolic aspartoacylase, ASPA, where variants are linked to Canavan disease, a lethal neurological disorder.

Simple Talectomy is a Beneficial Surgical Procedure for Talipes Equinovarus and Other Severe Neuromuscular Foot Deformities.

Noninvasive techniques are gold standard to redress Severe Neuromuscular Foot Deformity (SNFD). However, simple talectomy may be considered to obtain a stable, plantigrade, pain-free foot. We present a 10-year follow-up accessing radiological correction rates, functional outcomes, complications, and patient satisfaction.

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Non-pharmacological treatment for pain in children is seeing more interest as various interventions are investigated and found to be efficacious and free from adverse side effects. Some of the most used non-pharmacological treatments include distractive play, music therapy, virtual reality, hospital clowns, and hypnosis. This review summarises studies examining these modalities and finds that the available literature, although at times limited, mostly concludes that they are effective at reducing pain and/or anxiety in children.

Going the extra mile? General practitioners' upcoding of fees for home visits.

General practitioners' (GPs') income often relies on self-reported activities and performances. They can therefore 'game the system' to maximize their remuneration. We investigate whether Danish GPs game their travel fees for home visits.

Adipose tissue fibrosis: the unwanted houseguest invited by obesity.

The prevalence of obesity is increasing exponentially across the globe. The lack of effective treatment options for long-term weight loss has magnified the enormity of this problem. Studies continue to demonstrate that adipose tissue holds a biological memory, one of the most important determinant of long-term weight maintenance.

Mapping GPs' motivation — it's not all about the money: a nationwide cross-sectional survey study from Denmark.

Background: Understanding physicians' motivation may be essential for policymakers if they are to design policies that cater to physicians' wellbeing, job retention, and quality of care. However, physicians' motivation remains an understudied area.

Aim: To map GPs' work motivation.

Sensory Interactions between Sweetness and Fat in a Chocolate Milk Beverage.

Fat and sugar-reduced foods and beverages have become increasingly popular for a variety of reasons, mainly relating to health and wellbeing. Depending on the food or beverage, it may be difficult to reduce the fat and/or sugar content and still maintain optimal sensory properties for the specific product. One way of approaching the problem is to gain a better understanding of how a product is affected by a reduction in fat and/or sugar.

The link between physician motivation and care.

Studies report an unexplained variation in physicians' care. This variation may to some extent be explained by differences in their work motivation. However, empirical evidence on the link between physician motivation and care is scarce.

Cerebral palsy and bisphosphonates - and what can be learned from other types of secondary osteoporosis in children: A scoping review.

Aim: We aimed to improve bone health management of children with cerebral palsy (CP) by reviewing studies investigating bisphosphonate therapy in children with CP and other types of secondary osteoporosis.

Methods: We included trials on bisphosphonate treatment reporting any direct bone measurement or fracture outcome. All studies of patients with CP were included.

Barriers to assessing vulnerability in pregnant women. A cross-sectional survey in Danish general practice.

Background: Undetected vulnerability in pregnancy contributes to inequality in maternal and perinatal health and is associated with negative birth outcomes and adverse child outcomes. Nationwide reports indicate important barriers to assessing vulnerability among Danish general practitioners.

Objective: To explore general practitioners perceived barriers to vulnerability assessment in pregnant women and whether the barriers are associated with practice organization of antenatal care, general practitioner, and practice characteristics.