Assessing the Carcinogenic Potential of PFOA: A Molecular Network Approach to Liver Toxicity.

Perfluorooctanoic acid (PFOA), a prototypical per- and polyfluoroalkyl substance (PFAS), is widely used in industrial and consumer products but is classified as a Group 1 carcinogen by the IARC due to its environmental persistence and bioaccumulation. PFOA primarily targets the liver, inducing stress responses and mitochondrial-mediated apoptosis, while promoting hepatoma cell proliferation through the mTOR pathway. To investigate the molecular mechanisms of PFOA-induced liver cancer (LIHC), we will use a network toxicology approach that integrates multi-omics data to construct a compound-target-disease network, focusing on potential targets like ALDH1B1, which encodes the aldehyde dehydrogenase family in the major pathway of alcohol metabolism.

L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer.

The STAT3 pathway promotes epithelial-mesenchymal transition, migration, invasion and metastasis in cancer. STAT3 upregulates the transcription of the key epithelial-mesenchymal transition transcription factor SNAIL in a DNA binding-independent manner. However, the mechanism by which STAT3 is recruited to the SNAIL promoter to upregulate its expression is still elusive.

Association between red cell distribution width and all-cause mortality in patients with breast cancer: A retrospective analysis using MIMIC-IV 2.0.

Purpose: Investigating the association between red cell distribution width (RDW) and all-cause mortality in patients with breast cancer, to evaluate the potential clinical prognostic value of RDW.

Methods: Based on the RDW index, patients with breast cancer in the Medical Information Mart for Intensive Care (MIMIC-IV) database were categorized into quartiles. The primary outcomes included in-hospital mortality from all causes during the first six months, the first year, and the first three years.

Physiological functions of glucose transporter-2: From cell physiology to links with diabetes mellitus.

Glucose is a sugar crucial for human health since it participates in many biochemical reactions. It produces adenosine 5'-triphosphate (ATP) and nucleosides through glucose metabolic and pentose phosphate pathways. These processes require many transporter proteins to assist in transferring glucose across cells, and the most notable ones are glucose transporter-2 (GLUT-2) and sodium/glucose cotransporter 1 (SGLT1).