Publications by authors named "Lexin Ge"

To improve the understanding of potential pathological mechanisms of macular edema (ME), we try to discover biomarker candidates related to ME caused by diabetic retinopathy (DR) and retinal vein occlusion (RVO) in spectral-domain optical coherence tomography images by means of deep learning (DL). 32 eyes of 26 subjects with non-proliferative DR (NPDR), 77 eyes of 61 subjects with proliferative DR (PDR), 120 eyes of 116 subjects with branch RVO (BRVO), and 17 eyes of 15 subjects with central RVO (CRVO) were collected. A DL model was implemented to guide biomarker candidate discovery.

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By incorporating multiple indicators that facilitate clinical decision making and effective management of diabetic retinopathy (DR), a comprehensive understanding of the progression of the disease can be achieved. However, the diversity of DR complications poses challenges to the automatic analysis of various information within images. This study aims to establish a deep learning system designed to examine various metrics linked to DR in ultra-widefield fluorescein angiography (UWFA) images.

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Silicone oil has emerged as the common option for intraocular tamponade during complicated retina vitrectomy. However, the postoperative elevation of intraocular pressure (IOP), influenced by numerous factors, remains a significant and frequently encountered complication that poses a potential threat to vision. Extensive research has been conducted to investigate the risk factors associated with elevated IOP following silicone oil tamponade, including silicone oil viscosity, preoperative high IOP, diabetes, and lens status.

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Article Synopsis
  • The study aimed to identify risk factors and improve prediction models for elevated intraocular pressure (IOP) following vitreoretinal surgery using silicone oil.
  • Researchers analyzed data from over 1,000 patients, measuring IOP at various intervals post-surgery and using machine learning methods to predict outcomes based on demographic and clinical factors.
  • Results showed 26.01% of patients experienced elevated IOP, particularly within 1-2 weeks of surgery, with the most effective prediction model (Gradient-Boosted Decision Trees) achieving 79.44% accuracy and identifying key risk factors like age, sex, and pre-existing conditions.
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