Publications by authors named "Laura Perray"
Cutaneous lichen planus (LP) is an inflammatory skin disease characterized by an interface dermatitis with lymphocyte infiltration and keratinocyte (KC) cell death. The aim of this study was to investigate the immunopathogenesis of LP and assess the underlying mechanisms that drive the interface dermatitis reaction. We first performed single-cell RNA sequencing on lesional skins from patients with LP compared with healthy control skins and demonstrate that LP skin is imprinted by a type I IFN-rich environment.
View Article and Find Full Text PDFBackground: Cutaneous lupus erythematosus (CLE) is associated with unpredictable flares and may induce permanent damage. There is currently no biomarker routinely available in CLE.
Objective: To evaluate the performance of interferon-α (IFN-α) biological activity as biomarker of CLE activity and risk of flare.
Article Synopsis
- Cutaneous lupus erythematosus (CLE) can occur on its own or alongside systemic lupus erythematosus (SLE), where lab tests show specific abnormalities.
- This study aimed to compare isolated CLE to CLE with lab-confirmed SLE and to validate a scoring system predicting the risk of developing severe SLE (sSLE).
- Results indicated that patients with CLE and laboratory SLE had a significantly higher risk of progressing to sSLE compared to those with isolated CLE, though the study had limitations due to its small, single-center patient sample.
ANCA-associated scleritis: impact of ANCA on presentation, response to therapy and outcome.
Rheumatology (Oxford)
February 2024
Objectives: To describe the characteristics, treatment and outcome of isolated ANCA-associated scleritis at diagnosis compared with idiopathic scleritis with negative ANCA tests.
Methods: This retrospective multicentre case-control study was performed within the French Vasculitis Study Group (FVSG) network and in three French tertiary ophthalmologic centres. Data from patients with scleritis without any systemic manifestation and with positive ANCA results were compared with those of a control group of patients with idiopathic scleritis with negative ANCA tests.