Publications by authors named "Laura Diaz-Marugan"

Aim: Drug-resistant epilepsy (DRE) is a neurological disorder characterized by uncontrolled seizures. It affects between 10%-40% of the patients with epilepsy worldwide. Drug-resistant patients have been reported to have a different microbiota composition compared to drug-sensitive patients and healthy controls.

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Article Synopsis
  • - The study highlights the unique molecular characteristics of bone marrow in the skull, contrasting it with other bones and demonstrating its significant role in immune responses within the brain and meninges.
  • - Researchers found that mouse skull marrow exhibits a distinct transcriptomic profile, particularly in relation to neutrophils, and similar proteomic differences were observed in human skull marrow.
  • - Advanced imaging techniques reveal the structural connections between the skull and meninges, and the skull marrow's inflammatory response correlates with neurological disorders, suggesting its potential in diagnosing and treating brain diseases.
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Intestinal microbiota can influence the phenotype and function of immune cell responses through the dissemination of bacterial antigens or metabolites. Diet is one of the major forces shaping the microbiota composition and metabolism, contributing to host homeostasis and disease susceptibility. Currently, nutrition is a complementary and alternative approach to the management of metabolic and neurological diseases and cancer.

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Background: Respiratory and urinary tract infections are frequent complications in patients with severe stroke. Stroke-associated infection is mainly due to opportunistic commensal bacteria of the microbiota that may translocate from the gut. We investigated the mechanisms underlying gut dysbiosis and poststroke infection.

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Since the COVID-19 outbreak, researchers have tried to characterise the novel coronavirus SARS-CoV-2 to better understand the pathogenic mechanisms of the virus and prevent further dissemination. As a consequence, there has been a bloom in scientific research papers focused on the behaviour of the virus in different environmental contexts. Nevertheless, despite these efforts and due to its novelty, available information about this coronavirus is limited, as several research studies are still ongoing.

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Background and Purpose- Ischemia attracts neutrophils to the injured brain. However, neutrophil location and access to the damaged brain tissue is not yet entirely understood. We aimed to investigate neutrophil location in a mouse model of cerebral ischemia/reperfusion.

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