Publications by authors named "Laura Buergi"
Exposure to fire smoke has become a global health concern and is associated with increased morbidity and mortality. There is a lack of understanding of the specific immune mechanisms involved in smoke exposure, with preventive and targeted interventions needed. After exposure to fire smoke, which includes PM, toxic metals and perfluoroalkyl and polyfluoroalkyl substances, epidemiology-based studies have demonstrated increases in respiratory (for example, asthma exacerbation), cardiac (for example, myocardial infarction, arrhythmias), neurological (for example, stroke) and pregnancy-related (for example, low birthweight, premature birth) outcomes.
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- Ascaris infection, a common soil-transmitted helminth, may exacerbate asthma and allergic reactions through its influence on immune responses, specifically group-2 innate lymphoid cells (ILC2).
- * The study involved comparing non-infected and Ascaris-infected individuals, analyzing ILC subsets, their activation markers, and the presence of specific antibodies.
- * Results showed that ILC2 activation markers were significantly higher in Ascaris-infected individuals, particularly those sensitized to a specific Ascaris antigen, suggesting a link between helminth infection and enhanced immune responses.
Dupilumab treatment decreases MBC2s, correlating with reduced IgE levels in pediatric atopic dermatitis.
J Allergy Clin Immunol
November 2024
Background: A preference for type 2 immunity plays a central role in the pathogenesis of atopic dermatitis (AD). Dupilumab, an mAb targeting the IL-4 receptor α (IL-4Rα) subunit, inhibits IL-4 and IL-13 signaling. These cytokines contribute significantly to IgE class switch recombination in B cells, critical in atopic diseases.
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