Management of Relapsed/Refractory Myeloma in Resource Constrained Setting: Median age (years)Age (Years)Immunoglobulin subtypeHb (G/dL)Serum creatinineeGFR mL/minuteSerum albumin (g/dL) Serum LDHPlatelets countsCirculating plasma cells CytogeneticsHypercalcemiaCo-morbiditiesDiabetesHypertensionHypothyroidismF/H of malignancy.

Background: Treatment of relapse/refractory multiple myeloma (MM) is complex and requires consideration of disease, patients related factors and front-line treatment used. We aimed to assess the efficacy and safety of salvage regimens in symptomatic MM patients.

Methods: We evaluated records of relapse/refractory MM patients treated between 2014 and 2019.

Invasive Gastric Candidiasis With Concurrent Clostridioides difficile Colitis: A Case Report and Review of the Literature.

Invasive gastric candidiasis is a rare fungal infection of the stomach, often arising in the setting of immunosuppression, critical illness, mucosal barrier disruption, gut microbial alterations, or antibiotic use. Though are normal flora within the gastrointestinal tract, compromised host defenses can contribute to overgrowth and invasion of the fungal species into deeper tissues. We report a case of an 89-year-old man presenting with concurrent upper gastrointestinal bleeding from diffuse gastric ulcers secondary to invasive gastric candidiasis and diarrhea resulting from colitis.

A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation.

Schizophrenia (SZ) and bipolar disorder (BD) are characterized by social impairments. Social impairment also occurs in the general community. Across clinical and nonclinical groups social impairment may be related to deficits in social approach and/or social avoidance motivation.

Asymmetric Synthesis of Either Enantiomer of β-Butadienyl Amines by Isoprenylation of Davis-Ellman Imines.

The asymmetric synthesis of either enantiomer of β-butadienyl amines from a single starting material is described. Reversal of the diastereoselectivity is achieved by simply tuning the reaction conditions. This methodology provides excellent yields (up to 98%) and high diastereomeric ratios ( up to 98:2) and exhibits a broad substrate scope.

Smoking Prevalence, Susceptibility to Cigarette Smoking, and Its Causes in 568 Adolescent Male High School Students in Southern Saudi Arabia: A Cross-Sectional Study.

BACKGROUND Smoking is the single largest and most critical public health issue in the world, if smoking is initiated early in life, it can have long-term consequences. This study aimed to evaluate the prevalence of cigarette smoking in 568 adolescent male high school students in southern Saudi Arabia and their susceptibility to smoking using the Expanded Susceptibility to Smoking Index (ESSI), the short version of the UPPS-P Impulsive Behavior Scale (UPPS-P), and the Positive and Negative Affect Schedule (PANAS). MATERIAL AND METHODS A cross-sectional study was conducted among 568 male students aged 15-18 years in randomly selected high schools.