Multi-level association rule mining and network pharmacology to identify the polypharmacological effects of herbal materials and compounds in traditional medicine.

Many cultures worldwide have widely used traditional medicine (TM) to prevent or treat diseases. Herbal materials and their compounds used in TM offer many advantages for drug discovery, including cost-effectiveness, fewer side effects, and improved metabolism. However, the multi-compound and multi-target characteristics of TM prescriptions complicate drug discovery; meanwhile, previous studies have been limited by a lack of high-quality data, complex interpretation, and/or narrow analytical ranges.

Fermented soybean powder containing S-equol alleviates the postmenopausal signs of ovariectomized rats.

Unlabelled: Menopausal symptoms, including hot flashes, metabolic changes, and osteoporosis, significantly impact postmenopausal women. Given concerns about hormone replacement therapy, S-equol, a metabolite of the soybean isoflavone daidzein, has emerged as a potential alternative. This study explored the efficacy of S-equol-containing-supplement (SE5-OH), a fermented soy germ containing S-equol, on menopausal symptoms and osteoporosis in 6-month-old and 8-week-old ovariectomized (OVX) rat models.

Computational approaches to predict the toxicity of bioactive natural products: a mini review of methodologies.

Despite the increasing global demand for functional foods, the challenges associated with bioactive natural food products due to their complex composition remain. Bioactive natural products can potentially interfere with physiological activity regulation and lead to undesired side effects. This finding emphasizes the need for machine learning (ML)-based food safety predictions focused on intrinsic toxicity.

The Impact of Leaf Extract Consumption on Postprandial ApoB100 and Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Participants Subjected to an Oral High-Fat Challenge.

(PK) leaf extract, derived from Korean pine byproducts, holds promise for alleviating postprandial hyperlipidemia. In this study, we investigated the potential of PK leaf extract for modulating postprandial hyperlipidemia in adults with normal or borderline fasting triglyceride levels. In a randomized, double-blind, parallel design, 70 subjects were randomly assigned to either the placebo or PK group for 4 weeks.

Cinnamon () hot water extract improves inflammation and tight junctions in the intestine in vitro and in vivo.

Unlabelled: The natural byproduct was widely used in ancient Asia to cure disease because of its various pharmacological effects. Despite its ethnomedicinal benefits, few studies on the intestinal anti-inflammatory effect of have been reported. Therefore, this study aimed to evaluate the potential beneficial effects of on the intestine in vitro and in vivo.

Immunoenhancing Effects of on a Cyclophosphamide-Induced Immunosuppressive Mouse Model.

In this study, the effects of the immune stimulator (Euglena) in cyclophosphamide (CCP)-induced immunocompromised mice were assessed. The key component β-1,3-glucan (paramylon) constitutes 50% of . Mice were orally administered powder (250 and 500 mg/kg body weight (B.

Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.

Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets and finding specific drugs to target are especially needed, largely due to the increased frequency of anti-cancer drugs used in the treatment of lung cancer. Vaccinia-related kinase 1 (VRK1) is a master regulator in lung adenocarcinoma and is considered a key molecule in the adaptive pathway, which mainly controls cell survival.

Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier-to-autointegration factor phosphorylation.

To date, many anticancer drugs have been developed by directly or indirectly targeting microtubules, which are involved in cell division. Although this approach has yielded many anticancer drugs, these drugs produce undesirable side effects. An alternative strategy is needed, and targeting mitotic exit may be one alternative approach.