Agro-physiological and transcriptome profiling reveal key genes associated with potato tuberization under different nitrogen regimes in aeroponics.

Nitrogen (N) is a crucial nutrient for the growth and development of potatoes. However, excessive use of nitrogen fertilizers can have detrimental effects on human health, aquatic ecosystems, and the environment. Therefore, understanding the genes involved in nitrogen metabolism is essential for developing future strategies to improve nitrogen use efficiency (NUE) in plants.

Engaging males to improve nutrition outcomes in young children in Bihar.

Poor dietary practices among children aged 6-23 months pose a critical public health challenge, hindering their physical and cognitive development. The National Family Health Survey-5 (NFHS-5) reveals that only 11% of children in this age group consume diets meeting the minimum dietary diversity requirements. To address this, a targeted intervention was designed and implemented to improve dietary diversity in children.

Post-living donor liver transplant biliary strictures: prevalence, predictors, and long-term outcomes in a retrospective study.

Background: Post-liver transplant biliary strictures are a common cause of morbidity among patients who have undergone living donor liver transplantation (LDLT). Limited data are available concerning the response rates to various treatment modalities and the long-term outcomes for these individuals.

Methods: This study was a retrospective analysis of a prospectively collected database, including adult patients aged 18 years or older who underwent LDLT between 2006 and 2022.

Supergelation via Weak Interactions: An Efficient Method for the Fabrication of Hydrophobic Circularly Polarized Luminescent Materials.

The hydroxylated derivative of stearic acid, 12-hydroxy stearic acid (12-HSA), is derived from castor oil and possesses a unique chemical structure that renders it noteworthy in the field of cosmetics and medicine. Being derived from renewable sources, it aligns with the growing demand for sustainable and eco-friendly material. While the gelation properties of 12-HSA are known, its chiroptical properties remain unexplored.

Gossypol and Semisynthetic Derivatives: Chemistry, Bioactivities, and Mechanism of Actions.

Gossypol, a polyphenolic compound predominantly derived from cotton plants, has garnered significant attention as a notable plant-derived bioactive compound with significant relevance in medicinal chemistry due to its diverse biological activities and potential therapeutic applications. Despite its inherent toxicity, gossypol exhibits insecticidal, antimicrobial, antiviral, antifertility, antiparasitic, anti-inflammatory, antioxidant, and anticancer properties. Furthermore, gossypol serves as a core molecule for synthesizing various derivatives, such as gossypol Schiff bases, gossypolone, and apogossypol, which are less toxic yet retain similar therapeutic benefits.

Neurobiological Alterations Induced by SARS-CoV-2: Insights from Variant-Specific Host Gene Expression Patterns in hACE2-Expressing Mice.

Since the onset of the COVID-19 pandemic, various severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants have emerged. Although the primary site of SARS-CoV-2 infection is the lungs, it can also affect the brain and induce neurological symptoms. However, the specific effects of different variants on the brain remain unclear.

Bright fluorescent biocompatible Magnozyme nanoclusters for brain-cellin-vivo live imaging.

Multifluorescent, water-dispersible magnesium nanoclusters (Magnozyme) were obtained using a simple and economical synthesis procedure. The prepared particles were 4 nm in size, and they exhibited significant emission at 450, 545, and 628 nm with multiple excitations of 366,469 and 560 nm wavelengths. The prepared particle exhibited a maximum absolute quantum yield of 21.

Bilateral simultaneous proximal femoral fractures on dissimilar anatomical regions.

Simultaneous presentation of bilateral proximal femoral fractures following a traumatic event are considered very rare injuries. A literature search revealed that the fracture pattern in bilateral simultaneous proximal femoral fractures is most commonly similar to the anatomical region. We report a case of traumatic bilateral proximal femoral fractures with dissimilar pattern and anatomical location following a low energy trauma.

Management and outcomes of patients with ST-elevation myocardial infarction and liver disease-Insights from the Nationwide Readmissions Database.

Background: The association between cardiovascular disease and advanced liver disease is incompletely understood. To explore this interaction, we compared management, clinical outcomes, readmission rates, and resource utilization in ST-elevation myocardial infarction (STEMI) patients with and without liver disease.

Methods: The Nationwide Readmissions Database (2016-2020) was queried to identify hospitalizations for STEMI.

CRISPR-Cas9: Transforming Functional Genomics, Precision Medicine, and Drug Development - Opportunities, Challenges, and Future Directions.

CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) is a groundbreaking gene-editing technology that enables scientists to make precise changes to the DNA of living organisms. It was first discovered in Escherichia coli and emerged as a breakthrough tool in molecular biology. This technique is essential because of its adaptability, affordability, and ease of use.

Preoperative prediction of muscle invasion in bladder cancer in the Indian population using the Vesical Imaging-Reporting and Data System (VI-RADS) score and individual multiparametric magnetic resonance imaging (MRI) characteristics.

Aim: This study aimed to prospectively validate the Vesical Imaging-Reporting and Data System (VI-RADS) score in the preoperative prediction of muscle invasion in bladder cancer in the Indian population.

Materials And Methods: The study prospectively reviewed patients with bladder masses who underwent 1.5T multiparametric magnetic resonance imaging between December 2018 and April 2023.

Quality of Life and Healthcare Seeking Behavior among Internal Migrant Laborers in Coimbatore, India: A Community-based Analytical Cross-sectional Study.

Background: Globalization and urbanization have increased international and internal migration. However, migrants are still not absorbed into the local communities and remain vulnerable groups. Hence, the present study aimed to determine the quality of life (QoL) and healthcare-seeking behavior (HCSB) of internal migrant laborers in Coimbatore, Tamil Nadu.

"Exploration of Novel Anticancerous Agents Targeting Human Aurora Kinase C".

Aurora kinases (AKs), a family of serine/threonine kinases, play a vital role in chromosome segregation during the cell cycle (Mountzios et al., 2008). This family includes Aurora Kinase A (AKA), Aurora Kinase B (AKB), and Aurora Kinase C (AKC).

Characterization and treatment patterns of patients treated with immediate-release sodium oxybate for narcolepsy: A propensity score-matched cohort study.

Background: Sodium oxybate (SXB) is strongly recommended for narcolepsy treatment. Comorbidities and treatment patterns of patients with narcolepsy treated vs not treated with SXB are unknown.

Methods: An electronic health record-based search identified first-time Mayo Clinic patients with ≥ 1 narcolepsy-specific International Classification of Diseases 9th/10th Revision code and ≥ 1 diagnostic mention of narcolepsy in clinical notes (1975-2020).

A novel approach to forecasting reproduction numbers of spatiotemporal stochastic epidemic spread using a PDE-based model and real-time infection data.

The COVID-19 pandemic highlighted the need for improved epidemic spread forecasting, a critical precursor for developing optimal control measures for spread mitigation. Well-recognized shortcomings in computing basic and effective reproduction numbers ( , )-fundamental metrics for forecasting-underscore the need for new methods for estimating them from available data. We present a novel computational framework for estimating reproduction numbers from empirical spread data.

SNHG family lncRNAs: Key players in the breast cancer progression and immune cell's modulation.

Breast cancer, a highly prevalent form of cancer worldwide, has observed a steady increase in its prevalence over the past few decades. This rise can be attributed to the complex nature of the disease, characterized by its heterogeneity, ability to metastasize, and resistance to various treatment. In the field of cancer research, long non-coding RNAs (lncRNAs) are of special interest, which play an important role in the development and progression of various tumors, including breast cancer.

Oncological Outcomes in Patients with Delayed Cytoreductive Surgery During COVID Times.

ESMO ESGO guidelines recommend standard 3-4 cycles of neoadjuvant chemotherapy (NACT) for advanced epithelial ovarian cancers (EOC); however, the ideal number of cycles is still debatable. Literature regarding survival after 5 or more cycles is conflicting. COVID pandemic saw several oncosurgeries postponed due to healthcare crises.

Synergistic anti-inflammatory and anti-tb effects of Au-Pt-Cu nanofluids: experimental and computational insights.

Aims: To explore the potent anti-inflammatory and anti-tuberculosis potential of novel trimetallic Au-Pt-Cu nanofluids.

Materials & Methods: We employed BSA assay for anti-inflammatory assessment and tested anti-tuberculosis activity against H37Rv. Advanced molecular docking, dynamics, and DFT analyses were conducted to reveal interaction mechanisms and electronic properties.

Assessment and estimation of runoff and soil loss using novel machine learning techniques for conservation bench terraces.

Conservation of land and water resources, especially in terms of runoff and soil loss, has the utmost priority in enhancing agricultural production, especially in the foothills of the Himalayas. Many engineering measures have been applied to reduce runoff velocity and soil loss. The present study deals with the effectiveness of Conservation Bench Terraces (CBT) as engineering measures constructed in the outer foothills of the Himalayas (ICAR-IISWC, Dehradun, India) to reduce runoff and soil losses in the context of strom size.

Antioxidant activity of Mentha piperita phenolics on arsenic induced oxidative stress, biochemical alterations, and cyto-genotoxicity in fish, Channa punctatus.

The study aims to investigate the synergistic antioxidant effects of the phenolics present in Mentha piperita (MP) against arsenic trioxide-induced oxidative stress, biochemical alteration, and cyto-genotoxicity in the fish, Channa punctatus. The phenolic composition of MP estimated by HPLC-PDA analysis reveals the presence of phenolics, viz., ascorbic acid (Rt = 2.

Unveiling the potential of macroalgae Porphyra sp. (nori) in food, pharmaceutics and health sector.

Porphyra sp. (nori), a species of red seaweed, has garnered attention for its rich nutritional profile and diverse bioactive compounds. This review synthesizes current research on Porphyra nori, focusing on its composition, bioactive components, health benefits, and potential applications in functional foods and therapeutics.

Trends in mortality and disparities in dilated cardiomyopathy across gender, race, and region in the United States (1999-2020).

Background: Dilated cardiomyopathy (DCM) is a significant contributor to heart failure and sudden cardiac death in the United States. Understanding mortality trends associated with DCM is crucial to inform healthcare strategies and policy interventions to mitigate its burden.

Objectives: This study aimed to assess temporal trends in DCM-related mortality in the United States from 1999 to 2020, including an analysis of age-adjusted mortality rates (AAMRs), annual percent changes (APCs), and disparities across gender, racial/ethnic, geographic, and urbanization categories.

Natural Compounds and their Nano-formulations in Combating Autophagy-mediated Drug Resistance in Human Cancers.

Autophagy is a crucial mechanism that maintains cellular homeostasis and has emerged as a pivotal factor in cancer progression and drug resistance. Despite autophagic regulations being a complex process, convincing evidence shows that PI3K-Akt-mTOR, LKB1-AMPK-mTOR, and p53 pathways are the primary upstream regulators of the autophagy process. Currently, there is an immense amount of evidence demonstrating that autophagy plays a crucial role in cancer.