Temperature dependent human serum albumin Corona formation: A case study on gold nanorods and nanospheres.

Protein molecules interact with nanoparticles to form a protein layer on the surface called the protein corona. Corona formation can be affected by the temperature and shape of the nanoparticles thereby impacting the fate of the nanoparticles inside physiological systems. We have investigated the human serum albumin (HSA) corona formation and its interactions with gold nanospheres and nanorods at different temperatures (18-42 °C).

Thin Film Formation of HSA in the Presence of CTAB-Capped Gold Nanorods through Phase Separation.

Phase behavior in protein-nanoparticle systems in light of protein corona formation has been investigated. We report the formation of HSA thin films following the addition of a solid protein to a solution of CTAB-capped gold nanorods (AuNRs) via phase separation. The phase separation behavior was observed through UV-vis spectroscopy, turbidity assays, and DLS studies.

Cell Penetrability of a γ-Crystallin Peptide Fragment from the Discarded Cataractous Eye Emulsion.

The efficiency of the intracellular transport of medication and target specificity is frequently hampered by biological obstacles. The potential for therapeutic use of peptide fragments from naturally occurring proteins is promising, as peptides exhibit high selectivity due to several possibilities of interaction with their target. Certain peptide sequences, often referred to as cell-penetrating peptides (CPPs), are those that can penetrate cell membranes.

Understanding Conformational Changes in Human Serum Albumin and Its Interactions with Gold Nanorods: Do Flexible Regions Play a Role in Corona Formation?

The importance of protein-nanoparticle (NP) conjugates for biomedical applications has seen an exponential growth in the past few years. The protein corona formation on NPs with human serum albumin (HSA), being the most abundant protein in blood serum, has become one of the most studied protein analyses under NP-protein interactions as HSA is readily adsorbed on the surface of the NPs. Understanding the fate of the NPs in physiological media along with the change in biological responses due to the formation of the protein corona thus becomes important.

Thermodynamics of the Association of Aminoglycoside Antibiotics with Human Angiogenin.

Background: The body needs to maintain a firm balance between the inducers and inhibitors of angiogenesis, the process of proliferation of blood vessels from pre-existing ones. Human angiogenin (hAng), being a potent inducer of angiogenesis, is a cause of tumor cell proliferation, therefore its inhibition becomes a vital area of research. Aminoglycosides are linked ring systems consisting of amino sugars and an aminocyclitol ring and are in use in clinical practices for a long time.

Genomic DNA-mediated formation of a porous Cu(OH)PO/Co(PO)·8HO rolling pin shape bifunctional electrocatalyst for water splitting reactions.

Among the accessible techniques, the production of hydrogen by electrocatalytic water oxidation is the most established process, which comprises oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Here, we synthesized a genomic DNA-guided porous Cu(OH)PO/Co(PO)·8HO rolling pin shape composite structure in one pot. The nucleation and development of the porous rolling pin shape Cu(OH)PO/Co(PO)·8HO composite was controlled and stabilized by the DNA biomolecules.

Exploring of bacterial blight resistance in landraces and mining of resistant gene(s) using molecular markers and pathogenicity approach.

Unlabelled: Bacterial blight, one of the oldest and most severe diseases of rice poses a major threat to global rice production and food security. Thereafter, sustainable management of this disease has given paramount importance globally. In the current study, we explored 792 landraces to evaluate their disease reaction status against three highly virulent strains (, and ) of pv ().

Dumbbell-Shaped Ternary Transition-Metal (Cu, Ni, Co) Phosphate Bundles: A Promising Catalyst for the Oxygen Evolution Reaction.

Development of economical and high-performance electrocatalysts for the oxygen evolution reaction (OER) is of tremendous interest for future applications as sustainable energy materials. Here, a unique member of efficient OER electrocatalysts has been developed based upon structurally versatile dumbbell-shaped ternary transition-metal (Cu, Ni, Co) phosphates with a three-dimensional (3D) (Cu(OH)(PO)/Ni(PO)·8HO/Co(PO)·8HO) (CNCP) structure. This structure is prepared using a simple aqueous stepwise addition of metal ion source approach.

Restriction of microwave-induced amyloid fibrillar growth by gold nanoparticles.

Microwave radiations from various electronic devices are of serious health concern. In this article, using spectroscopic measurements, we show that the microwave radiation of strength 22 dBm and frequency 10 GHz facilitates protein fibrillation. However, this adverse effect of low-field radiation can be restricted by the presence of biocompatible citrate-capped gold nanoparticles.

EMI shielding of ABS composites filled with different temperature-treated equal-quantity charcoals.

Acrylonitrile-butadiene-styrene (ABS) composites were prepared by dry mixing equal-quantity (20 wt%) charcoals treated at different temperatures followed by hot compression. Processing parameters were kept the same. Seven samples of the same charcoal were modified for carbonization at different temperatures varying from 500 °C to 1100 °C in steps of 100 °C.