Publications by authors named "Kosuke Ochi"
Article Synopsis
- The study focuses on understanding how lung cancer cells develop resistance to crizotinib, a MET tyrosine kinase inhibitor, particularly in cases of MET amplification.
- Researchers established two MET-amplified lung cancer cell lines, EBC-1 and H1993, to explore the mechanisms behind this acquired resistance, using genomic and transcriptomic data for analysis.
- Findings revealed various resistance mechanisms, including SERPINE1 overexpression in EBC-1 cells and potential therapies like PAI-1 inhibitors or MEK inhibitors for overcoming resistance in these cancer cells.
Article Synopsis
- Cancer-associated fibroblasts (CAFs) play a key role in helping cancer cells resist treatment, particularly in non-small cell lung cancer (NSCLC), by fostering a supportive tumor environment.
- Tranilast, an antiallergic medication, was shown to reduce cytokine release from CAFs, affecting their interaction with NSCLC cells and mitigating drug resistance.
- The study found that using tranilast alongside targeted therapy not only counteracted the protective effects of CAFs but also reversed resistance to drugs like osimertinib and selumetinib in NSCLC cells.
Overcoming epithelial-mesenchymal transition-mediated drug resistance with monensin-based combined therapy in non-small cell lung cancer.
Biochem Biophys Res Commun
August 2020
Background: The epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis and is also associated with drug resistance. Thus, controlling EMT status is a research of interest to conquer the malignant tumors.
Materials And Methods: A drug repositioning analysis of transcriptomic data from a public cell line database identified monensin, a widely used in veterinary medicine, as a candidate EMT inhibitor that suppresses the conversion of the EMT phenotype.
Preparation and biocompatibility of a chitin nanofiber/gelatin composite film.
Int J Biol Macromol
November 2017
The development of chitin-based materials with favorable mechanical properties and biocompatibility is an important research goal owing to the wide-ranging practical applications. In this study, a composite film was prepared using chitin nanofibers and gelatin. The CNF/gelatin composite film was highly viscous and had a fine nanofiber structure.
View Article and Find Full Text PDFThis study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
View Article and Find Full Text PDFPrevious reports indicate that the beneficial effect of chitin nanofibrils (CNFs), and chitosan nanofibrils (CSNFs) for wound healing. In this study, the wound healing effects of superficially deacetylated chitin nanofibrils (SDACNFs) were evaluated using an experimental model. In the experiments using circular excision wound model, SDACNFs induced re-epithelium and proliferation of the fibroblasts and collagen tissue.
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