Publications by authors named "Konstantinos Garefis"

Recent evidence has suggested that sialendoscopy should be the first-line treatment for chronic sialadenitis. This study aimed to assess the efficacy of steroid irrigation during sialendoscopy in non-lithiasic chronic sialadenitis. We conducted a systematic search of the databases of PubMed, Scopus, and Web of Science up to the 3rd of November 2024 for completed studies investigating the efficacy of steroid irrigation during sialendoscopy for chronic non-lithiasic sialadenitis.

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Background: Surgical interventions for nasal obstruction represent a significant proportion of everyday rhinology practice. Failure to improve patients' symptoms may be due to incomplete assessment of co-morbidities, low sensitivity for nasal airflow, and inadequate therapeutic approaches. This narrative review summarizes the evidence on studies assessing the results of nasal obstruction surgery in relation to trigeminal function measurements.

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Background: The intranasal trigeminal system contributes to the sense of smell. Its integrity in olfactory dysfunction (OD) may be crucial for future treatments. This study assessed trigeminal sensitivity in healthy individuals and patients with OD of different etiologies using electrical stimulation of the nasal mucosa.

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Introduction: Lateral cervical cystic masses are a relatively common occurrence in the otolaryngology practice, which are often attributed to second branchial cleft cysts. However, there should always be a high suspicion for malignancy until proven otherwise.

Case Presentation: We present a clinical report of a lateral cervical cyst surgical excision where histopathological examination has revealed features of a branchial cleft cyst harboring a papillary thyroid carcinoma.

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Article Synopsis
  • This study investigates the effectiveness of adenotonsillectomy (ATE) versus watchful waiting in children with Obstructive Sleep Apnea Syndrome (OSAS), examining their clinical outcomes through a meta-analysis of various trials.
  • The results show ATE leads to significant improvements in the apnea-hypopnea index (AHI) and quality of life (measured by OSA-18 scores), but no noticeable difference was found in oxygen saturation levels (SpO2) between the two treatment options.
  • Subgroup analysis also indicated ATE is particularly beneficial for mild OSAS cases, showcasing significant improvements compared to watchful waiting.
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Adenoid cystic carcinoma (ACC) is an uncommon malignant neoplasm that predominantly arises from major and minor salivary glands, accounting for about 1% of head and neck malignancies. ACCs originating from the pterygopalatine fossa (PPF) are extremely rare. In this case report, we present a 77-year-old male patient who experienced a two-year hemi-facial numbness and mild trismus, with intact nasal mucosa.

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Introduction: The complex nature of xerostomia prevents the establishment of a definite cure. Recently, research has pivoted towards stem cell transplantation for glandular reconstruction. The aim of this study is to provide an updated review of the existing research, to highlight the encountered challenges and research pathways, potentially enhancing the therapeutic applications of stem cell transplantation.

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Article Synopsis
  • This study explores the link between vitamin D deficiency and recurrent tonsillopharyngitis by reviewing data from 11 observational studies involving over 2,500 participants.
  • The findings suggest a possible connection, with most studies indicating a statistically significant relationship between low vitamin D levels and increased occurrences of tonsillopharyngitis.
  • While the quality of the included studies was generally moderate to good, the authors recommend further research into the preventive effects of vitamin D supplementation on this condition.
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Article Synopsis
  • The study focuses on understanding the impact of COVID-19 symptoms on daily life and the needs of those affected in France.
  • A significant portion of participants found their symptoms to be debilitating, impacting their mental and physical health, as well as their social and work lives.
  • Many individuals reported unmet needs for medical and psychological support, and they preferred non-invasive treatments for issues like anosmia over more invasive options.
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(1) Background: Submandibular gland (SMG) sialolithiasis treatment has shifted significantly, favouring minimal invasiveness. Nonetheless, transoral stone removal remains viable for distal, deep hilar, and intraparenchymal stones. However, data are limited regarding recurrence and revision surgery; (2) Patients/Methods: This retrospective study included 226 patients with SMG stones treated using Wharton's duct slitting and marsupialisation over nine years; 138 had deep hilar or intraparenchymal stones, while 88 had distal stones.

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Background: The trigeminal nerve is a mixed cranial nerve responsible for the motor innervation of the masticatory muscles and the sensory innervation of the face, including the nasal cavities. Through its nasal innervation, we perceive sensations, such as cooling, tingling, and burning, while the trigeminal system mediates the perception of airflow. However, the intranasal trigeminal system has received little attention in the clinical evaluation of patients with nasal pathology.

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Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue sarcomas, with 50% of cases associated with type 1 neurofibromatosis (NF-1). A 27-year-old male patient was referred to our department with an extended right nasal cavity MPNST. The lesion extended to the skull base, intracranial, parapharyngeal space, and infratemporal fossa.

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Impalement of children with foreign bodies is not uncommon. A variety of foreign bodies and mechanisms of injuries have been described. Infant tissues are more vulnerable to injuries and often penetrating traumas are very dangerous.

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Purpose: Sialendoscopy is a new, minimally invasive method that is becoming increasingly more popular than traditional methods for the treatment of sialolithiasis. In this systematic review and meta-analysis, the effectiveness and safety of this method in children with sialolithiasis are investigated.

Methods: Inclusion criteria were children with sialolithiasis.

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Objective: Recent evidence has suggested that performing a tonsillectomy with CO laser results in favorable intraoperative and postoperative outcomes. This study aimed to compare the clinical outcomes of CO and dissection tonsillectomy.

Methods: We conducted a systematic search in PubMed, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL), until the 1st of September 2021 for completed studies comparing intraoperative and postoperative outcomes of CO laser and dissection tonsillectomy.

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Objectives: Peritonsillar abscess is a common complication of acute tonsillitis. However, no consensus has been reached yet on the optimal treatment of this condition. Therefore, this study aimed to compare clinical outcomes of immediate and interval abscess tonsillectomy.

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Introduction: Recurrent respiratory papillomatosis (RRP) is classically described as a benign neoplasm of the larynx. Nevertheless, transformation to dysplasia and invasive carcinoma can occur. Sarcoma of the larynx is rare.

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