Phillyrin sensitizes lung cancer cells to ferroptosis through inhibiting FTH1/SLC7A11 axis.

Ferroptosis is a newly found form of non-apoptotic regulated cell death that is essential for cancer progression. Phillyrin (PHN), an effective lignan glycoside of , has been explored as a potential anticancer agent in some cancer types. However, it is unclear whether and how PHN could promote the death of non-small cell lung cancer (NSCLC) cells by inducing ferroptosis.

Non-spreading Bessel spatiotemporal optical vortices.

Non-spreading nature of Bessel spatiotemporal wavepackets is theoretically and experimentally investigated and orders of magnitude improvement in the spatiotemporal spreading has been demonstrated. The spatiotemporal confinement provided by the Bessel spatiotemporal wavepacket is further exploited to transport transverse orbital angular momentum through embedding spatiotemporal optical vortex into the Bessel spatiotemporal wavepacket, constructing a new type of wavepacket: Bessel spatiotemporal optical vortex. Both numerical and experimental results demonstrate that spatiotemporal vortex structure can be well maintained and confined through much longer propagation.

Combined Orthopaedic and Vascular Injuries With Ischemia: A Multicenter Analysis.

Objectives: To review a large, multicenter experience to identify the current salvage and amputation rates of these combined injuries and, where possible, the variables that predict amputation.

Design: Retrospective.

Setting: Nine trauma centers.

Sleep disturbances in orthopaedic trauma patients.

Objectives: To determine the prevalence of sleep disturbances in orthopaedic trauma patients 3 months following surgery and to identify any subset(s) of patients at high risk for prolonged sleep disturbance.

Design: Prospective cohort.

Setting: Level 1 Trauma Center.

Patient Engagement and Cost Savings Achieved by Automated Telemonitoring Systems Designed to Prevent and Identify Surgical Site Infections After Joint Replacement.

Background: We designed two telemonitoring text and voice messaging interventions, EpxDecolonization (EpxDecol) and EpxWound, to improve management of orthopedic joint replacement patients at Washington University. We reviewed the use of these tools for a period of 88 weeks.

Methods: Cohorts of 1,392 and 1,753 participants completed EpxDecol and EpxWound, respectively.

Accessible Communication Tools for Surgical Site Infection Monitoring and Prevention in Joint Reconstruction: Feasibility Study.

Background: The National Surgical Quality Improvement Program logs surgical site infections (SSIs) as the most common cause of unplanned postoperative readmission for a variety of surgical interventions. Hospitals are making significant efforts preoperatively and postoperatively to reduce SSIs and improve care. Telemedicine, defined as using remote technology to implement health care, has the potential to improve outcomes across a wide range of parameters, including reducing SSIs.

Use of Short Message Service and Smartphone Applications in the Management of Surgical Patients: A Systematic Review.

Background: Mobile health and telemedicine are rapidly evolving fields used to provide healthcare remotely to patients. For surgical patients, telemedicine can improve patient education and remote monitoring of postoperative symptoms. We performed a systematic review of studies involving the use of short message service (SMS) and mobile application-based interventions in surgical patients to evaluate the advantages and disadvantages of each system, as well as of mobile interventions as a whole.