Publications by authors named "Kemal Alper Onsu"
Article Synopsis
- Optimizing oncolytic viruses for cancer treatment involves removing harmful genes and adding new ones to improve their ability to replicate and stimulate immune responses.
- The complex nature of viral genomes and the difficulty of creating modified viruses have slowed progress in developing these therapies.
- Researchers used a novel strategy involving antibiotics, transposon systems, and advanced sequencing to efficiently engineer safer and more effective oncolytic viruses by identifying useful genetic changes.
Depolymerization of actin filaments by Cucurbitacin I through binding G-actin.
Food Sci Nutr
February 2024
Cucurbitacins have high economic value as they are a major source of food and have pharmacological properties. Cucurbitacin I (CuI) is a plant-derived natural tetracyclic triterpenoid compound that shows an anticancer effect via inhibiting the JAK2-STAT3 signaling pathway. The actin cytoskeleton is the most abundant protein in cells and regulates critical events through reorganization in cells.
View Article and Find Full Text PDFThe large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral replication as well as timing and dosing of transgene expression in order to facilitate safe and efficacious payload delivery. Herein, we adapt drug-controlled gene switches to enable control of virally encoded transgene expression, including systems controlled by the FDA-approved rapamycin and doxycycline.
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