Publications by authors named "Keiko Tanoue"
IntroductionRepeated injections of low-dose lipopolysaccharide (LPS preconditioning) augment the antibacterial activity of liver macrophages. In this study, a mouse model of acute kidney injury (AKI) induced by bacteremia was used to investigate the effects of LPS preconditioning on renal macrophages.MethodsEight-week-old C57BL/6J mice were preconditioned with either low-dose LPS (5 μg/kg) or the vehicle for three consecutive days.
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- A percutaneous kidney biopsy (PKB) is important for treating kidney diseases but has a risk of bleeding complications, which are influenced by factors like urinary N-acetyl-β-D-glucosaminidase (NAG) levels.
- In a study of 213 patients, about 25% experienced significant hemoglobin loss after undergoing PKB, and higher urinary NAG/Cr levels were linked to an increased risk of bleeding events.
- The study suggests that urinary NAG/Cr can predict not only the severity of kidney disease but also potential bleeding risks during and after the biopsy procedure.
Objectives: Several therapeutic agents have been developed and used for the clinical treatment of systemic lupus erythematosus (SLE). In cases where SLE is accompanied by severe organ failures, such as neuropsychiatric lupus erythematosus (NPSLE) and acute onset of lupus nephritis, the use of potent immunosuppressive drugs, such as cyclophosphamide, is necessary. However, potent immunosuppressive drugs are known to increase infection risks.
View Article and Find Full Text PDFl-Carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells.
Am J Physiol Renal Physiol
March 2024
Article Synopsis
- * A study found that patients with severe heat-related illness and AKI had elevated serum acylcarnitine levels, indicating carnitine insufficiency.
- * Administering l-carnitine to heat-stressed mice improved mitochondrial function and reversed harmful changes in kidney macrophages, suggesting that enhancing FAO could help prevent heat stress-induced AKI.
SGLT2 and SGLT1 inhibitors suppress the activities of the RVLM neurons in newborn Wistar rats.
Hypertens Res
January 2024
Hypertension is well-known to often coexist with diabetes mellitus (DM) in humans. Treatment with sodium-glucose cotransporter 2 (SGLT2) inhibitors has been shown to decrease both the blood glucose and the blood pressure (BP) in such patients. Some reports show that SGLT2 inhibitors improve the BP by decreasing the activities of the sympathetic nervous system.
View Article and Find Full Text PDFThe mortality rate for acute kidney injury (AKI) due to sepsis remains high, and effective therapies based on its pathogenesis remain elusive. Macrophages are crucial for clearing bacteria from vital organs, including the kidney, under septic conditions. Excessive macrophage activation results in organ injury.
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